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Protein

Probable Xaa-Pro aminopeptidase PEPP

Gene

PEPP

Organism
Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.By similarity

Catalytic activityi

Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi256Manganese 2By similarity1
Metal bindingi267Manganese 1By similarity1
Metal bindingi267Manganese 2By similarity1
Metal bindingi390Manganese 1By similarity1
Metal bindingi430Manganese 1By similarity1
Metal bindingi430Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandManganese, Metal-binding

Protein family/group databases

MEROPSiM24.A09

Names & Taxonomyi

Protein namesi
Recommended name:
Probable Xaa-Pro aminopeptidase PEPP (EC:3.4.11.9)
Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase
Gene namesi
Name:PEPP
Ordered Locus Names:Pa_0_1330
ORF Names:PODANS_0_1330
OrganismiPodospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383) (Pleurage anserina)
Taxonomic identifieri515849 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesLasiosphaeriaceaePodospora
Proteomesi
  • UP000001197 Componenti: Chromosome 7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004118851 – 460Probable Xaa-Pro aminopeptidase PEPPAdd BLAST460

Interactioni

Protein-protein interaction databases

STRINGi515849.XP_001904550.1

Structurei

3D structure databases

ProteinModelPortaliB2AFW1
SMRiB2AFW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M24B family.Curated

Phylogenomic databases

eggNOGiKOG2737 Eukaryota
COG0006 LUCA
KOiK14213
OrthoDBiEOG092C3XFN

Family and domain databases

Gene3Di3.40.350.10, 1 hit
InterProiView protein in InterPro
IPR007865 Aminopep_P_N
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
PfamiView protein in Pfam
PF05195 AMP_N, 1 hit
PF00557 Peptidase_M24, 1 hit
SMARTiView protein in SMART
SM01011 AMP_N, 1 hit
SUPFAMiSSF53092 SSF53092, 1 hit
SSF55920 SSF55920, 1 hit

Sequencei

Sequence statusi: Complete.

B2AFW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYNKILQGK YPAKQHAKRV SDYIRDKIPN ATGVLYLEGR ATKMIEDNDS
60 70 80 90 100
EEHFRQRRYF YYLTGCPLAD SYVIHDMDSS KTTLFIPPVD PESVIWSGLP
110 120 130 140 150
VSAEEALSNW DVDEVKYTNE INATLAHVGA SKANATLYAI PNQVSEKVTF
160 170 180 190 200
LEFDHKNFSI LKEAIEVTRV VKDEYEIAMI GKANQISSRA HELVMKKVKH
210 220 230 240 250
VKNERELEAV FLAECISNGA RDQAYHSIVA AGRAAATLHY VANNAPLDGK
260 270 280 290 300
LNLLLDAGGE WNCYASDITR TFPINGKFTT ESRAIYDIVL KMQLECIATL
310 320 330 340 350
KEGVVWDDVH TLAHKIAIDG LLELGILKGD KEAILESRTS VAFFPHGLGH
360 370 380 390 400
YLGMDTHDTG GNANYADKDT MFRYLRVRGT LPAGSVITVE PGLYFCNFII
410 420 430 440 450
EPFLNDPKHS QYINRPVLDR YWDVGGVRIE DNIVITKRGT QNLTTAVKDP
460
DEMERLIASS
Length:460
Mass (Da):51,598
Last modified:May 20, 2008 - v1
Checksum:i95352002DB686952
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU633464 Genomic DNA Translation: CAP62332.1
FO904942 Genomic DNA Translation: CDP31638.1
RefSeqiXP_001904550.1, XM_001904515.1

Genome annotation databases

EnsemblFungiiCAP62332; CAP62332; PODANS_0_1330
GeneIDi6188706
KEGGipan:PODANSg1572

Similar proteinsi

Entry informationi

Entry nameiAMPP3_PODAN
AccessioniPrimary (citable) accession number: B2AFW1
Secondary accession number(s): A0A090DAM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: May 20, 2008
Last modified: October 25, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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