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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 12FADUniRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Nther_1382
OrganismiNatranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)
Taxonomic identifieri457570 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaNatranaerobialesNatranaerobiaceaeNatranaerobius
Proteomesi
  • UP000001683 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003463661 – 433Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST433

Proteomic databases

PRIDEiB2A334

Interactioni

Protein-protein interaction databases

STRINGi457570.Nther_1382

Structurei

3D structure databases

ProteinModelPortaliB2A334
SMRiB2A334
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108FW6 Bacteria
COG1206 LUCA
HOGENOMiHOG000252054
KOiK04094
OMAiRFGPMKP
OrthoDBiPOG091H00B3

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit

Sequencei

Sequence statusi: Complete.

B2A334-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLTVIGGGL AGSEAAYQAA QQGVTVDLYE MRPVKTTAAH KTGELAELVC
60 70 80 90 100
SNSLRAKSLE NAAGLLKEEL RKFDSLIMKV ADQVQVPAGG ALAVDREAFS
110 120 130 140 150
QKVTEYIENH PNINLITEEV TEINESQPTV IATGPLTSTS LTERIQKLTG
160 170 180 190 200
TDFLYFYDAA APIVTYESIN KNIAYWASRY GKGTPDYLNC PMTKEEYEDF
210 220 230 240 250
YQELINAEKV PLKSFEKEVV FEGCMPVEQM ANRGKDTLVF GPLKPVGLEN
260 270 280 290 300
PNTGEMPYAV VQLRKDNREG TLYNLVGFQT RLKWPEQRRV FRKIPGLEEA
310 320 330 340 350
EFVRYGVMHR NTFINSPKVL TANYQLRERP GLFFAGQVTG VEGYVESTAS
360 370 380 390 400
GLVAGLNAAR KLQGNETLTF PRETALGALA SYIVEASPDN FQPMNINFGL
410 420 430
LPSLEKKVPK KIKKQKQSER ALKILEEFIE RKL
Length:433
Mass (Da):48,280
Last modified:May 20, 2008 - v1
Checksum:i5CBC6436875B61AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001034 Genomic DNA Translation: ACB84965.1
RefSeqiWP_012447840.1, NC_010718.1

Genome annotation databases

EnsemblBacteriaiACB84965; ACB84965; Nther_1382
KEGGinth:Nther_1382

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001034 Genomic DNA Translation: ACB84965.1
RefSeqiWP_012447840.1, NC_010718.1

3D structure databases

ProteinModelPortaliB2A334
SMRiB2A334
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi457570.Nther_1382

Proteomic databases

PRIDEiB2A334

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB84965; ACB84965; Nther_1382
KEGGinth:Nther_1382

Phylogenomic databases

eggNOGiENOG4108FW6 Bacteria
COG1206 LUCA
HOGENOMiHOG000252054
KOiK04094
OMAiRFGPMKP
OrthoDBiPOG091H00B3

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRMFO_NATTJ
AccessioniPrimary (citable) accession number: B2A334
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 20, 2008
Last modified: October 10, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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