Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene

accD

Organism
Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.UniRule annotation

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOTER452637:G1GBP-3595-MONOMER
UniPathwayiUPA00655; UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaUniRule annotation (EC:2.1.3.15UniRule annotation)
Short name:
ACCase subunit betaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit betaUniRule annotation
Gene namesi
Name:accDUniRule annotation
Ordered Locus Names:Oter_3526
OrganismiOpitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1)
Taxonomic identifieri452637 [NCBI]
Taxonomic lineageiBacteriaVerrucomicrobiaOpitutaeOpitutalesOpitutaceaeOpitutus
Proteomesi
  • UP000007013 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003898091 – 291Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaAdd BLAST291

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotation

Protein-protein interaction databases

STRINGi452637.Oter_3526

Structurei

3D structure databases

ProteinModelPortaliB1ZVD6
SMRiB1ZVD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 291CoA carboxyltransferase N-terminalPROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Belongs to the AccD/PCCB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QTG Bacteria
COG0777 LUCA
HOGENOMiHOG000021670
KOiK01963
OMAiPEGLWIK
OrthoDBiPOG091H04JK

Family and domain databases

HAMAPiMF_01395 AcetylCoA_CT_beta, 1 hit
InterProiView protein in InterPro
IPR034733 AcCoA_carboxyl
IPR000438 Acetyl_CoA_COase_Trfase_b_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011762 COA_CT_N
PfamiView protein in Pfam
PF01039 Carboxyl_trans, 1 hit
PRINTSiPR01070 ACCCTRFRASEB
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00515 accD, 1 hit
PROSITEiView protein in PROSITE
PS50980 COA_CT_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

B1ZVD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHFDKPTYT VRKTRKKEIP QGVYTKDPVS GEAVFTKDIA DNQMVVPASG
60 70 80 90 100
HHFPIGARER LGYLLDPGSF VESNIEVRSA DPLQFVDSAP YPARIKKYEK
110 120 130 140 150
ESGLPEAVVT GAGKIHGVPV SLAVMDFRFC GGTLGSAAGE KITRAIETAI
160 170 180 190 200
AQKIPCIIFS TSGGARMQEG ILSLMQMAKT SAALGRLAAA RLPYISVLTH
210 220 230 240 250
PTTGGVSASY ATLGDVILAE PGALIGFAGP RVIKDTTKQT LPPGFQTSEF
260 270 280 290
LLKHGLIDQI VPRTEMRERL HQILLALYVK QTPASASVAK S
Length:291
Mass (Da):31,173
Last modified:May 20, 2008 - v1
Checksum:iB3737F498AB9AE63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001032 Genomic DNA Translation: ACB76803.1
RefSeqiWP_012376332.1, NC_010571.1

Genome annotation databases

EnsemblBacteriaiACB76803; ACB76803; Oter_3526
KEGGiote:Oter_3526

Similar proteinsi

Entry informationi

Entry nameiACCD_OPITP
AccessioniPrimary (citable) accession number: B1ZVD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: May 20, 2008
Last modified: June 20, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health