UniProtKB - B1Z6M0 (B1Z6M0_BURA4)
Protein
Submitted name:
Type VI secretion ATPase, ClpV1 family
Gene
BamMC406_6693
Organism
Burkholderia ambifaria (strain MC40-6)
Status
Functioni
Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.ARBA annotation
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
Keywordsi
Molecular function | ChaperoneARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | BAMB398577:G1GBO-6645-MONOMER |
Names & Taxonomyi
Protein namesi | Submitted name: Type VI secretion ATPase, ClpV1 familyImported |
Gene namesi | Ordered Locus Names:BamMC406_6693Imported |
Encoded oni | Plasmid pBMC401Imported |
Organismi | Burkholderia ambifaria (strain MC40-6)Imported |
Taxonomic identifieri | 398577 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › |
Proteomesi |
|
Interactioni
Subunit structurei
Homohexamer. The oligomerization is ATP-dependent.
ARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 151 | Clp RInterPro annotationAdd BLAST | 143 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 473 – 493 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the ClpA/ClpB family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_005070_1_1_4 |
OrthoDBi | 44062at2 |
Family and domain databases
Gene3Di | 1.10.1780.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR017729, ATPase_T6SS_ClpV1 IPR019489, Clp_ATPase_C IPR036628, Clp_N_dom_sf IPR004176, Clp_R_dom IPR001270, ClpA/B IPR018368, ClpA/B_CS1 IPR041546, ClpA/ClpB_AAA_lid IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF07724, AAA_2, 1 hit PF17871, AAA_lid_9, 1 hit PF02861, Clp_N, 1 hit PF10431, ClpB_D2-small, 1 hit |
PRINTSi | PR00300, CLPPROTEASEA |
SMARTi | View protein in SMART SM00382, AAA, 2 hits SM01086, ClpB_D2-small, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF81923, SSF81923, 1 hit |
TIGRFAMsi | TIGR03345, VI_ClpV1, 1 hit |
PROSITEi | View protein in PROSITE PS51903, CLP_R, 1 hit PS00870, CLPAB_1, 1 hit |
i Sequence
Sequence statusi: Complete.
B1Z6M0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTISRQALFG KLSHSLFRSV ESATTFCKLR GNPYVELVHW LHQLLQAPDG
60 70 80 90 100
DLQRIVRHCD IDAETLDRDV LRALAALPAG ASSISDFSHH VETTIERAWV
110 120 130 140 150
LASLNFGDRR IRGAWLVAAL VKTPELRRVL LSISPAFGKI PLDSLAEMLP
160 170 180 190 200
AWIDGSPEAG DAPYDGTDFG GAVPGEVAGA LAPSMAGGSP LEQYCSDLTA
210 220 230 240 250
RARAGEIDPV VGRELEIRTM IDVLLRRRQN NPLLTGDAGV GKTAVVEGLA
260 270 280 290 300
RAVVDGDVPP KLADVRLLSL DVGALLAGAS MKGEFEARLK GVLEAATKST
310 320 330 340 350
VPVILFVDEI HTLIGAGGHA GTGDAANLLK PALARGTLRT IGATTWSEYK
360 370 380 390 400
RYIEKDPALT RRFQVLQVPE PEEAAAIDMV RGLARTFSRH HGVVLLDEAI
410 420 430 440 450
RAAVTLSHRY IPSRQLPDKA ISLLDTACAR VALSQHAPPG ELQDVRQRLQ
460 470 480 490 500
AARVECDLID HEWRIGLGDG DALARSRARI ADLEREADGV EARWRAQADA
510 520 530 540 550
AQALLSAREA AAEAQGDVPD AGLHAFERAL ADLQGETALV FPEVNEVIVA
560 570 580 590 600
EIVSDWTGIP VRRMVTDEVT AVLALPDTLS ARVIGQSDAL LQIGERVQTA
610 620 630 640 650
RAGLTDPKKP LGVFLLAGPS GVGKTETALA LAEALYGGEQ NLITINMSEY
660 670 680 690 700
QEAHTVSGLK GAPPGYVGYG EGGVLTEAVR RRPYSVVLLD EIEKAHGDVH
710 720 730 740 750
EMFFQVFDKG YMEDGDGRYI DFRHTTILLT SNAGSDLIAS LCADEMLVPD
760 770 780 790 800
ADALRTALVP ELLKTFPAAF LGRVTVVPYR PLAQATLSQI VRLHLDRVVA
810 820 830 840 850
RMADGHGVAF SYAPAVLDYI VDRCLVQETG ARLLIGFLEQ HVLPRLAAQW
860 870 880
LDALESKRTL TRVELDLADA GAAPAEAFVF HASGAQADE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001028 Genomic DNA Translation: ACB69097.1 |
RefSeqi | WP_012367331.1, NC_010553.1 |
Genome annotation databases
EnsemblBacteriai | ACB69097; ACB69097; BamMC406_6693 |
KEGGi | bac:BamMC406_6693 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001028 Genomic DNA Translation: ACB69097.1 |
RefSeqi | WP_012367331.1, NC_010553.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
EnsemblBacteriai | ACB69097; ACB69097; BamMC406_6693 |
KEGGi | bac:BamMC406_6693 |
Phylogenomic databases
HOGENOMi | CLU_005070_1_1_4 |
OrthoDBi | 44062at2 |
Enzyme and pathway databases
BioCyci | BAMB398577:G1GBO-6645-MONOMER |
Family and domain databases
Gene3Di | 1.10.1780.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR017729, ATPase_T6SS_ClpV1 IPR019489, Clp_ATPase_C IPR036628, Clp_N_dom_sf IPR004176, Clp_R_dom IPR001270, ClpA/B IPR018368, ClpA/B_CS1 IPR041546, ClpA/ClpB_AAA_lid IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF07724, AAA_2, 1 hit PF17871, AAA_lid_9, 1 hit PF02861, Clp_N, 1 hit PF10431, ClpB_D2-small, 1 hit |
PRINTSi | PR00300, CLPPROTEASEA |
SMARTi | View protein in SMART SM00382, AAA, 2 hits SM01086, ClpB_D2-small, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF81923, SSF81923, 1 hit |
TIGRFAMsi | TIGR03345, VI_ClpV1, 1 hit |
PROSITEi | View protein in PROSITE PS51903, CLP_R, 1 hit PS00870, CLPAB_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B1Z6M0_BURA4 | |
Accessioni | B1Z6M0Primary (citable) accession number: B1Z6M0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | February 10, 2021 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |