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Protein

Probable tRNA pseudouridine synthase D

Gene

truD

Organism
Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:Tneu_1594
OrganismiPyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus)
Taxonomic identifieri444157 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001694 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001368561 – 412Probable tRNA pseudouridine synthase DAdd BLAST412

Proteomic databases

PRIDEiB1Y9W7

Interactioni

Protein-protein interaction databases

STRINGi444157.Tneu_1594

Structurei

3D structure databases

ProteinModelPortaliB1Y9W7
SMRiB1Y9W7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini167 – 370TRUDUniRule annotationAdd BLAST204

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04252 Archaea
COG0585 LUCA
HOGENOMiHOG000224849
KOiK06176
OMAiLRYERAM
OrthoDBiPOG093Z087N

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 2 hits
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

B1Y9W7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIEAPPFDRS LGMLYYATDT YPSGGVIKAK PEDFLVEEVL YDGTVVALEG
60 70 80 90 100
VSIEPRVGGW TWIHVVKRNV DTVKLVLRLA KALGLRSRDI SIGGIKDTRA
110 120 130 140 150
VTSQIVSVRG NVADLPKIPN VQFLGLWPMD KPIAPSLIYG NRFTIVLRNV
160 170 180 190 200
ERRECAEAAL AALGKAALPN YYGYQRFGTI RPVSHLLGKA LLRKDAEGFF
210 220 230 240 250
HVMFCKIFPY ESEAAKKARE LACRGEYQKA LEAFPRGFVE ERALLRRLVR
260 270 280 290 300
GSDLWNAAMA IPLQILRIYI EAAQSHLFNL LLSKRMELGP LDRPVEGDLV
310 320 330 340 350
EVNGQVTYYV EDLGGEVVVP VVGAGVRMPR GRVLEAFVKV LKEEGLEPSA
360 370 380 390 400
FLQMPRGLRA YGSYRRARLQ ARDLAYSLGD DLVLRFVLPR GGYATVLLRE
410
VVKPTEPYRH GF
Length:412
Mass (Da):46,015
Last modified:May 20, 2008 - v1
Checksum:iB071CD7F78BB66B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001014 Genomic DNA Translation: ACB40517.1

Genome annotation databases

EnsemblBacteriaiACB40517; ACB40517; Tneu_1594
KEGGitne:Tneu_1594

Similar proteinsi

Entry informationi

Entry nameiTRUD_PYRNV
AccessioniPrimary (citable) accession number: B1Y9W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: September 12, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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