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Protein

Epoxyqueuosine reductase

Gene

queG

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).UniRule annotation

Catalytic activityi

Queuosine(34) in tRNA + acceptor + H2O = epoxyqueuosine(34) in tRNA + reduced acceptor.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi187Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi190Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi193Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi197Iron-sulfur 2UniRule annotation1
Metal bindingi241Iron-sulfur 2UniRule annotation1
Metal bindingi244Iron-sulfur 2UniRule annotation1
Metal bindingi248Iron-sulfur 1 (4Fe-4S)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processQueuosine biosynthesisUniRule annotation, tRNA processingUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
Epoxyqueuosine reductaseUniRule annotation (EC:1.17.99.6UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueGUniRule annotation
Gene namesi
Name:queGUniRule annotation
Ordered Locus Names:SYNPCC7002_A1957Imported
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)Imported
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001688 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A1957

Structurei

3D structure databases

ProteinModelPortaliB1XQP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 2074Fe-4S ferredoxin-typeInterPro annotationAdd BLAST33

Sequence similaritiesi

Belongs to the QueG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EH2 Bacteria
COG1600 LUCA
HOGENOMiHOG000272644
KOiK18979
OMAiVDGSKCI
OrthoDBiPOG091H01VA

Family and domain databases

HAMAPiMF_00916 QueG, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR013542 DUF1730
IPR009051 Helical_ferredxn
IPR004453 QueG
PANTHERiPTHR30002 PTHR30002, 1 hit
PfamiView protein in Pfam
PF08331 DUF1730, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR00276 TIGR00276, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

B1XQP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQLQTDRTI RVKNYALSLG FHLVGIADAT VDNAHNQQQL QAWLAAGYQA
60 70 80 90 100
EMAWMANPKR QDIQACLPGV QSVICVALNY YTPHAHSEAP GVGKISRYGW
110 120 130 140 150
GRDYHRVLGK RLKAFCQWLT KEFPEEHHRF YVDTGPVQDK VWAERAGLGW
160 170 180 190 200
IAKNSNVITR EYGSWVFLGE VLTTLALTPD QPHTKHCGTC TRCIEACPTE
210 220 230 240 250
AIAAPFTVDA NRCIAYHTIE NRAEQLPPHI APHLQNWVAG CDICQDVCPW
260 270 280 290 300
NQRFAQPTNI EDFQPYPKHL APKLAELATL SETEWDQRLT GSALRRIKPA
310
MWRRNAQANL DHQP
Length:314
Mass (Da):35,542
Last modified:May 20, 2008 - v1
Checksum:i5EAA49829C167626
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000951 Genomic DNA Translation: ACA99944.1
RefSeqiWP_012307567.1, NC_010475.1

Genome annotation databases

EnsemblBacteriaiACA99944; ACA99944; SYNPCC7002_A1957
KEGGisyp:SYNPCC7002_A1957

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000951 Genomic DNA Translation: ACA99944.1
RefSeqiWP_012307567.1, NC_010475.1

3D structure databases

ProteinModelPortaliB1XQP9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A1957

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA99944; ACA99944; SYNPCC7002_A1957
KEGGisyp:SYNPCC7002_A1957

Phylogenomic databases

eggNOGiENOG4105EH2 Bacteria
COG1600 LUCA
HOGENOMiHOG000272644
KOiK18979
OMAiVDGSKCI
OrthoDBiPOG091H01VA

Enzyme and pathway databases

UniPathwayi
UPA00392

Family and domain databases

HAMAPiMF_00916 QueG, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR013542 DUF1730
IPR009051 Helical_ferredxn
IPR004453 QueG
PANTHERiPTHR30002 PTHR30002, 1 hit
PfamiView protein in Pfam
PF08331 DUF1730, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR00276 TIGR00276, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1XQP9_SYNP2
AccessioniPrimary (citable) accession number: B1XQP9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 10, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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