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Protein

Zinc finger CCHC domain-containing protein 7

Gene

Zcchc7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri238 – 255CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri260 – 277CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri301 – 318CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri345 – 362CCHC-type 4PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 7
Alternative name(s):
TRAMP-like complex RNA-binding factor ZCCHC7
Gene namesi
Name:Zcchc7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310467 Zcchc7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003702421 – 542Zinc finger CCHC domain-containing protein 7Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei142PhosphoserineCombined sources1
Cross-linki236Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki251Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki336Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki410Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki432Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki474Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei478PhosphoserineBy similarity1
Modified residuei480PhosphoserineBy similarity1
Cross-linki485Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki488Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki531Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiB1WC15
PeptideAtlasiB1WC15
PRIDEiB1WC15

PTM databases

iPTMnetiB1WC15
PhosphoSitePlusiB1WC15

Interactioni

Subunit structurei

Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017707

Structurei

3D structure databases

ProteinModelPortaliB1WC15
SMRiB1WC15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri238 – 255CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri260 – 277CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri301 – 318CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri345 – 362CCHC-type 4PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IUGX Eukaryota
ENOG41123PW LUCA
HOGENOMiHOG000155768
InParanoidiB1WC15
KOiK12597
PhylomeDBiB1WC15

Family and domain databases

InterProiView protein in InterPro
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 2 hits
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 4 hits
SUPFAMiSSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B1WC15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGGFETIEA FEDDLYRDDS SSELSVDSEV EFQLYSQVHY SQNIHNANEE
60 70 80 90 100
EGYEEKNCES SETVSIQPDQ KNLIVLSDSE VIQLSDTSEV ITLSDEDSIY
110 120 130 140 150
RCKRKNIEVQ AQEKTQSPAT PRSNKVANKC KRSNKKPEPE ESPSTIREVM
160 170 180 190 200
IIEVSSDEEE ESTISENENV ESWMLLGCEE DDKDNDILLN LVGCKDAGAE
210 220 230 240 250
GENDVNWFIS DKDIEAKIDN NRSSGRWNNR YYSVNKNVTC RNCDKRGHLS
260 270 280 290 300
KNCPLPQKVR PCCLCSERGH LQYGCPARYC LDCSLPMSST HRCFERSSWR
310 320 330 340 350
KRCDRCDMIG HYADACPEIW RQYHLTTKPG PPKKPKTPSG QSALVYCYNC
360 370 380 390 400
AQKGHYGHEC TERRMFNQAF PTSPFIYCYD DKYDIQQRDR RIKRKLKDIK
410 420 430 440 450
KNGDFPRQFK RPHGEETDRY HHDRRKSRFS GKRSRWPRES KETQKEKTRG
460 470 480 490 500
REGEKHRRDR QPRDEDEDFP RGLKPNSSSS SNSQKPSKSL HQASHYHRLR
510 520 530 540
EEKLRRESMR SKPKKRKFVE DGSHDDLFLI KQRKKKPKSS GF
Length:542
Mass (Da):63,326
Last modified:May 20, 2008 - v1
Checksum:iE5473B1F09405C2F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M989F1M989_RAT
Zinc finger CCHC domain-containing ...
Zcchc7
542Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473962 Genomic DNA Translation: EDL98795.1
BC161967 mRNA Translation: AAI61967.1
RefSeqiNP_001100128.1, NM_001106658.2
UniGeneiRn.56971

Genome annotation databases

GeneIDi298086
KEGGirno:298086
UCSCiRGD:1310467 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473962 Genomic DNA Translation: EDL98795.1
BC161967 mRNA Translation: AAI61967.1
RefSeqiNP_001100128.1, NM_001106658.2
UniGeneiRn.56971

3D structure databases

ProteinModelPortaliB1WC15
SMRiB1WC15
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017707

PTM databases

iPTMnetiB1WC15
PhosphoSitePlusiB1WC15

Proteomic databases

PaxDbiB1WC15
PeptideAtlasiB1WC15
PRIDEiB1WC15

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi298086
KEGGirno:298086
UCSCiRGD:1310467 rat

Organism-specific databases

CTDi84186
RGDi1310467 Zcchc7

Phylogenomic databases

eggNOGiENOG410IUGX Eukaryota
ENOG41123PW LUCA
HOGENOMiHOG000155768
InParanoidiB1WC15
KOiK12597
PhylomeDBiB1WC15

Miscellaneous databases

PROiPR:B1WC15

Family and domain databases

InterProiView protein in InterPro
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 2 hits
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 4 hits
SUPFAMiSSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZCHC7_RAT
AccessioniPrimary (citable) accession number: B1WC15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 20, 2008
Last modified: July 18, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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