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UniProtKB - B1WC15 (ZCHC7_RAT)
Protein
Zinc finger CCHC domain-containing protein 7
Gene
Zcchc7
Organism
Rattus norvegicus (Rat)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 238 – 255 | CCHC-type 1PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 260 – 277 | CCHC-type 2PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 301 – 318 | CCHC-type 3PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 345 – 362 | CCHC-type 4PROSITE-ProRule annotationAdd BLAST | 18 |
GO - Molecular functioni
- nucleic acid binding Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger CCHC domain-containing protein 7Alternative name(s): TRAMP-like complex RNA-binding factor ZCCHC7 |
Gene namesi | Name:Zcchc7 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1310467, Zcchc7 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Nucleus
- nucleolus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000370242 | 1 – 542 | Zinc finger CCHC domain-containing protein 7Add BLAST | 542 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 129 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 136 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 142 | PhosphoserineCombined sources | 1 | |
Cross-linki | 236 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 251 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 336 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 410 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 432 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 474 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 478 | PhosphoserineBy similarity | 1 | |
Modified residuei | 480 | PhosphoserineBy similarity | 1 | |
Cross-linki | 485 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 488 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 531 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | B1WC15 |
PeptideAtlasi | B1WC15 |
PRIDEi | B1WC15 |
PTM databases
iPTMneti | B1WC15 |
PhosphoSitePlusi | B1WC15 |
Interactioni
Subunit structurei
Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000017707 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 110 – 144 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 396 – 542 | DisorderedSequence analysisAdd BLAST | 147 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 111 – 127 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 396 – 424 | Basic and acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 433 – 472 | Basic and acidic residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 473 – 490 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 494 – 533 | Basic and acidic residuesSequence analysisAdd BLAST | 40 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 238 – 255 | CCHC-type 1PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 260 – 277 | CCHC-type 2PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 301 – 318 | CCHC-type 3PROSITE-ProRule annotationAdd BLAST | 18 | |
Zinc fingeri | 345 – 362 | CCHC-type 4PROSITE-ProRule annotationAdd BLAST | 18 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG4400, Eukaryota |
InParanoidi | B1WC15 |
OrthoDBi | 1535084at2759 |
PhylomeDBi | B1WC15 |
Family and domain databases
InterProi | View protein in InterPro IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF00098, zf-CCHC, 2 hits |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 4 hits |
SUPFAMi | SSF57756, SSF57756, 1 hit |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B1WC15-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFGGFETIEA FEDDLYRDDS SSELSVDSEV EFQLYSQVHY SQNIHNANEE
60 70 80 90 100
EGYEEKNCES SETVSIQPDQ KNLIVLSDSE VIQLSDTSEV ITLSDEDSIY
110 120 130 140 150
RCKRKNIEVQ AQEKTQSPAT PRSNKVANKC KRSNKKPEPE ESPSTIREVM
160 170 180 190 200
IIEVSSDEEE ESTISENENV ESWMLLGCEE DDKDNDILLN LVGCKDAGAE
210 220 230 240 250
GENDVNWFIS DKDIEAKIDN NRSSGRWNNR YYSVNKNVTC RNCDKRGHLS
260 270 280 290 300
KNCPLPQKVR PCCLCSERGH LQYGCPARYC LDCSLPMSST HRCFERSSWR
310 320 330 340 350
KRCDRCDMIG HYADACPEIW RQYHLTTKPG PPKKPKTPSG QSALVYCYNC
360 370 380 390 400
AQKGHYGHEC TERRMFNQAF PTSPFIYCYD DKYDIQQRDR RIKRKLKDIK
410 420 430 440 450
KNGDFPRQFK RPHGEETDRY HHDRRKSRFS GKRSRWPRES KETQKEKTRG
460 470 480 490 500
REGEKHRRDR QPRDEDEDFP RGLKPNSSSS SNSQKPSKSL HQASHYHRLR
510 520 530 540
EEKLRRESMR SKPKKRKFVE DGSHDDLFLI KQRKKKPKSS GF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1M989 | F1M989_RAT | Zinc finger CCHC domain-containing ... | Zcchc7 | 542 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473962 Genomic DNA Translation: EDL98795.1 BC161967 mRNA Translation: AAI61967.1 |
RefSeqi | NP_001100128.1, NM_001106658.2 |
Genome annotation databases
GeneIDi | 298086 |
KEGGi | rno:298086 |
UCSCi | RGD:1310467, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473962 Genomic DNA Translation: EDL98795.1 BC161967 mRNA Translation: AAI61967.1 |
RefSeqi | NP_001100128.1, NM_001106658.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000017707 |
PTM databases
iPTMneti | B1WC15 |
PhosphoSitePlusi | B1WC15 |
Proteomic databases
PaxDbi | B1WC15 |
PeptideAtlasi | B1WC15 |
PRIDEi | B1WC15 |
Genome annotation databases
GeneIDi | 298086 |
KEGGi | rno:298086 |
UCSCi | RGD:1310467, rat |
Organism-specific databases
CTDi | 84186 |
RGDi | 1310467, Zcchc7 |
Phylogenomic databases
eggNOGi | KOG4400, Eukaryota |
InParanoidi | B1WC15 |
OrthoDBi | 1535084at2759 |
PhylomeDBi | B1WC15 |
Miscellaneous databases
PROi | PR:B1WC15 |
Family and domain databases
InterProi | View protein in InterPro IPR001878, Znf_CCHC IPR036875, Znf_CCHC_sf |
Pfami | View protein in Pfam PF00098, zf-CCHC, 2 hits |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 4 hits |
SUPFAMi | SSF57756, SSF57756, 1 hit |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZCHC7_RAT | |
Accessioni | B1WC15Primary (citable) accession number: B1WC15 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 14, 2009 |
Last sequence update: | May 20, 2008 | |
Last modified: | February 23, 2022 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |