UniProtKB - B1WBX9 (B1WBX9_RAT)
Protein
Cytokine-inducible SH2-containing protein
Gene
Cish
Organism
Rattus norvegicus (Rat)
Status
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Biological processi
- intracellular signal transduction Source: InterPro
- negative regulation of signal transduction Source: UniProtKB-KW
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- protein ubiquitination Source: UniProtKB-UniPathway
- regulation of growth Source: UniProtKB-KW
Keywordsi
Molecular function | Signal transduction inhibitorARBA annotation |
Biological process | Growth regulationARBA annotation, Ubl conjugation pathwayARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-8951664, Neddylation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytokine-inducible SH2-containing proteinARBA annotation |
Gene namesi | Name:CishImported ORF Names:rCG_25823Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 69261, Cish |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000029543, Expressed in skeletal muscle tissue and 21 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 82 – 163 | SH2InterPro annotationAdd BLAST | 82 | |
Domaini | 208 – 256 | SOCS boxInterPro annotationAdd BLAST | 49 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 169 – 192 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 178 – 192 | Pro-richSequence analysisAdd BLAST | 15 |
Keywords - Domaini
SH2 domainPROSITE-ProRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000157392 |
HOGENOMi | CLU_079452_4_1_1 |
OMAi | VKTRCGP |
OrthoDBi | 1135696at2759 |
TreeFami | TF321368 |
Family and domain databases
CDDi | cd10718, SH2_CIS, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR028425, CIS IPR035887, CIS_SH2 IPR000980, SH2 IPR036860, SH2_dom_sf IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF9, PTHR10155:SF9, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF07525, SOCS_box, 1 hit |
PRINTSi | PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B1WBX9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLCVQGSCP LLVVEQIGQR PLWAQSLELP GPAMQPLPTG AFPEEVTEET
60 70 80 90 100
PVQSENEPKV LDPEGDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP
110 120 130 140 150
EGTFLVRDST HPSYLFTLSV KTTRGPTNVR IEYADSSFRL DSNCLSRPRI
160 170 180 190 200
LAFPDVVSLV QHYVASCTAD TRSDSPDPAP TPALPVPKPD APGDPVLPIP
210 220 230 240 250
VATAVHLKLV QPFVRRSSAR SLQHLCRLVI NRLVTDVDCL PLPRRMADYL
RQYPFQL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketO70512 | CISH_RAT | Cytokine-inducible SH2-containing p... | Cish | 256 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07071447 Genomic DNA No translation available. BC161930 mRNA Translation: AAI61930.1 CH473954 Genomic DNA Translation: EDL77261.1 |
RefSeqi | NP_113992.1, NM_031804.1 |
Genome annotation databases
Ensembli | ENSRNOT00000040056; ENSRNOP00000041734; ENSRNOG00000029543 |
GeneIDi | 83681 |
KEGGi | rno:83681 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07071447 Genomic DNA No translation available. BC161930 mRNA Translation: AAI61930.1 CH473954 Genomic DNA Translation: EDL77261.1 |
RefSeqi | NP_113992.1, NM_031804.1 |
3D structure databases
SMRi | B1WBX9 |
ModBasei | Search... |
Proteomic databases
PRIDEi | B1WBX9 |
Genome annotation databases
Ensembli | ENSRNOT00000040056; ENSRNOP00000041734; ENSRNOG00000029543 |
GeneIDi | 83681 |
KEGGi | rno:83681 |
Organism-specific databases
CTDi | 1154 |
RGDi | 69261, Cish |
Phylogenomic databases
GeneTreei | ENSGT00940000157392 |
HOGENOMi | CLU_079452_4_1_1 |
OMAi | VKTRCGP |
OrthoDBi | 1135696at2759 |
TreeFami | TF321368 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-RNO-8951664, Neddylation |
Gene expression databases
Bgeei | ENSRNOG00000029543, Expressed in skeletal muscle tissue and 21 other tissues |
Family and domain databases
CDDi | cd10718, SH2_CIS, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR028425, CIS IPR035887, CIS_SH2 IPR000980, SH2 IPR036860, SH2_dom_sf IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf |
PANTHERi | PTHR10155:SF9, PTHR10155:SF9, 1 hit |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF07525, SOCS_box, 1 hit |
PRINTSi | PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit |
SUPFAMi | SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B1WBX9_RAT | |
Accessioni | B1WBX9Primary (citable) accession number: B1WBX9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | February 10, 2021 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |