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UniProtKB - B1WBU4 (ZBT8A_RAT)
Protein
Zinc finger and BTB domain-containing protein 8A
Gene
Zbtb8a
Organism
Rattus norvegicus (Rat)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 282 – 304 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 333 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- transcription coactivator binding Source: Ensembl
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 8A |
Gene namesi | Name:Zbtb8a |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1308756, Zbtb8a |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000378510 | 1 – 441 | Zinc finger and BTB domain-containing protein 8AAdd BLAST | 441 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 161 | PhosphoserineBy similarity | 1 | |
Modified residuei | 167 | PhosphoserineBy similarity | 1 | |
Cross-linki | 178 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 182 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 199 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 437 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | B1WBU4 |
PRIDEi | B1WBU4 |
PTM databases
iPTMneti | B1WBU4 |
PhosphoSitePlusi | B1WBU4 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000008300, Expressed in pancreas and 21 other tissues |
Genevisiblei | B1WBU4, RN |
Interactioni
GO - Molecular functioni
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
- transcription coactivator binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000010983 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 92 | BTBPROSITE-ProRule annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 135 – 248 | DisorderedSequence analysisAdd BLAST | 114 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 137 – 163 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 225 – 239 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 282 – 304 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 333 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157491 |
HOGENOMi | CLU_022356_1_1_1 |
InParanoidi | B1WBU4 |
OMAi | YSSGWQE |
OrthoDBi | 755439at2759 |
PhylomeDBi | B1WBU4 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
i Sequence
Sequence statusi: Complete.
B1WBU4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEISSHQSHL LEQLNEQRRQ DVFCDCSILV EGKVFKAHRN VLFASSGYFK
60 70 80 90 100
MLLSQNSKET SQPTTATFQT FSPDTFTVIL DFVYSGKLSL TGQNVIEVMS
110 120 130 140 150
AASFLQMTDV ISVCKTFIKS SLDISEKEKD RYFSLSDKDT GSNGVERPSV
160 170 180 190 200
YSSSWQEDGG SPRSHLSPDQ GPAIVSGKPW NKYSYHPASQ RSPQPPLAKH
210 220 230 240 250
EQRKDPIKKT KHLRLPQPSE VVHFKSGKGD ARTSDSGHHV SQSEEQVQVD
260 270 280 290 300
AEVDPVSAGY PYSQGPEVAS RSFPDNLPRL RFKCPYCTHV VKRKADLKRH
310 320 330 340 350
LRCHTGERPY PCQACGKRFS RLDHLSSHFR TIHQACKLIC RKCKRHVTDL
360 370 380 390 400
TGQVVQEGTR RYRLCNECLT EVGMDSLPAD LETEQHRVSP ADGDKDCRWH
410 420 430 440
LSEEENRSYV EIVEDGSADL VIQQVDDSEE EEEKEIKPNI R
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC161892 mRNA Translation: AAI61892.1 |
RefSeqi | XP_006238993.1, XM_006238931.3 |
Genome annotation databases
Ensembli | ENSRNOT00000010983; ENSRNOP00000010983; ENSRNOG00000008300 |
GeneIDi | 313049 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC161892 mRNA Translation: AAI61892.1 |
RefSeqi | XP_006238993.1, XM_006238931.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000010983 |
PTM databases
iPTMneti | B1WBU4 |
PhosphoSitePlusi | B1WBU4 |
Proteomic databases
PaxDbi | B1WBU4 |
PRIDEi | B1WBU4 |
Genome annotation databases
Ensembli | ENSRNOT00000010983; ENSRNOP00000010983; ENSRNOG00000008300 |
GeneIDi | 313049 |
Organism-specific databases
CTDi | 653121 |
RGDi | 1308756, Zbtb8a |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000157491 |
HOGENOMi | CLU_022356_1_1_1 |
InParanoidi | B1WBU4 |
OMAi | YSSGWQE |
OrthoDBi | 755439at2759 |
PhylomeDBi | B1WBU4 |
Miscellaneous databases
PROi | PR:B1WBU4 |
Gene expression databases
Bgeei | ENSRNOG00000008300, Expressed in pancreas and 21 other tissues |
Genevisiblei | B1WBU4, RN |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT8A_RAT | |
Accessioni | B1WBU4Primary (citable) accession number: B1WBU4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 7, 2009 |
Last sequence update: | May 20, 2008 | |
Last modified: | February 23, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |