Zbtb8a

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	282 – 304	C2H2-type 1PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	310 – 333	C2H2-type 2PROSITE-ProRule annotationAdd BLAST		24

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 8A
Gene namesⁱ	Name:Zbtb8a
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 5

Organism-specific databases

Rat genome database More...RGDⁱ	1308756 Zbtb8a

RGDⁱ

1308756 Zbtb8a

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000378510	1 – 441	Zinc finger and BTB domain-containing protein 8AAdd BLAST		441

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	161	PhosphoserineBy similarity	1
Modified residueⁱ	167	PhosphoserineBy similarity	1
Cross-linkⁱ	178	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	182	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	199	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	437	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	B1WBU4
PRIDEⁱ	B1WBU4

PTM databases

iPTMnetⁱ	B1WBU4
PhosphoSitePlusⁱ	B1WBU4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000008300 Expressed in 9 organ(s), highest expression level in heart
Genevisibleⁱ	B1WBU4 RN

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000010983

STRINGⁱ

10116.ENSRNOP00000010983

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B1WBU4
SMRⁱ	B1WBU4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 92	BTBPROSITE-ProRule annotationAdd BLAST		69

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	429 – 435	Poly-Glu		7

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	282 – 304	C2H2-type 1PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	310 – 333	C2H2-type 2PROSITE-ProRule annotationAdd BLAST		24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148950
HOGENOMⁱ	HOG000124661
InParanoidⁱ	B1WBU4
OMAⁱ	KYNYHPA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05WK
PhylomeDBⁱ	B1WBU4

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 2 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 2 hits PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

B1WBU4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEISSHQSHL LEQLNEQRRQ DVFCDCSILV EGKVFKAHRN VLFASSGYFK 
        60         70         80         90        100
MLLSQNSKET SQPTTATFQT FSPDTFTVIL DFVYSGKLSL TGQNVIEVMS 
       110        120        130        140        150
AASFLQMTDV ISVCKTFIKS SLDISEKEKD RYFSLSDKDT GSNGVERPSV 
       160        170        180        190        200
YSSSWQEDGG SPRSHLSPDQ GPAIVSGKPW NKYSYHPASQ RSPQPPLAKH 
       210        220        230        240        250
EQRKDPIKKT KHLRLPQPSE VVHFKSGKGD ARTSDSGHHV SQSEEQVQVD 
       260        270        280        290        300
AEVDPVSAGY PYSQGPEVAS RSFPDNLPRL RFKCPYCTHV VKRKADLKRH 
       310        320        330        340        350
LRCHTGERPY PCQACGKRFS RLDHLSSHFR TIHQACKLIC RKCKRHVTDL 
       360        370        380        390        400
TGQVVQEGTR RYRLCNECLT EVGMDSLPAD LETEQHRVSP ADGDKDCRWH 
       410        420        430        440 
LSEEENRSYV EIVEDGSADL VIQQVDDSEE EEEKEIKPNI R

Length:441

Mass (Da):49,945

Last modified:May 20, 2008 - v1

Checksum:ⁱ15655FAA7E99D15E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC161892 mRNA Translation: AAI61892.1
NCBI Reference Sequences More...RefSeqⁱ	XP_006238993.1, XM_006238931.3
UniGeneⁱ	Rn.82564

Genome annotation databases

Ensemblⁱ	ENSRNOT00000010983; ENSRNOP00000010983; ENSRNOG00000008300
GeneIDⁱ	313049

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
B1WBU4	Zinc finger and BTB domain-containing protein 8A		MOUSE		434	UniRef90_Q9CWH1
UPI000154E196		RAT		391
UPI000A3169DC		MUSCR		435
UPI000A317424		MUSCR		385

Protein	Similar proteins		Species	Score	Length	Source
B1WBU4	Zinc finger and BTB domain-containing protein 8A		HUMAN		441	UniRef50_Q96BR9
Zinc finger and BTB domain-containing protein 8A		BOVIN		441
Zinc finger and BTB domain-containing protein 8A		MOUSE		434
Zinc finger and BTB domain-containing protein 8A		HETGA		447
Zinc finger and BTB domain containing 8A		PIG		441
+138

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC161892 mRNA Translation: AAI61892.1
RefSeqⁱ	XP_006238993.1, XM_006238931.3
UniGeneⁱ	Rn.82564

3D structure databases

ProteinModelPortalⁱ	B1WBU4
SMRⁱ	B1WBU4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000010983

STRINGⁱ

10116.ENSRNOP00000010983

PTM databases

iPTMnetⁱ	B1WBU4
PhosphoSitePlusⁱ	B1WBU4

Proteomic databases

PaxDbⁱ	B1WBU4
PRIDEⁱ	B1WBU4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000010983; ENSRNOP00000010983; ENSRNOG00000008300
GeneIDⁱ	313049

Organism-specific databases

CTDⁱ	653121
RGDⁱ	1308756 Zbtb8a

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00920000148950
HOGENOMⁱ	HOG000124661
InParanoidⁱ	B1WBU4
OMAⁱ	KYNYHPA
OrthoDBⁱ	EOG091G05WK
PhylomeDBⁱ	B1WBU4

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:B1WBU4

PROⁱ

PR:B1WBU4

Gene expression databases

Bgeeⁱ	ENSRNOG00000008300 Expressed in 9 organ(s), highest expression level in heart
Genevisibleⁱ	B1WBU4 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 2 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 2 hits PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBT8A_RAT
Accessionⁱ	B1WBU4Primary (citable) accession number: B1WBU4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 7, 2009
	Last sequence update:	May 20, 2008
	Last modified:	October 10, 2018
	This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B1WBU4 (ZBT8A_RAT)

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Zinc finger and BTB domain-containing protein 8A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ