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Protein

Zinc finger and BTB domain-containing protein 8A

Gene

Zbtb8a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri282 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 333C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 8A
Gene namesi
Name:Zbtb8a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1308756 Zbtb8a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003785101 – 441Zinc finger and BTB domain-containing protein 8AAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki437Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiB1WBU4
PRIDEiB1WBU4

PTM databases

iPTMnetiB1WBU4
PhosphoSitePlusiB1WBU4

Expressioni

Gene expression databases

BgeeiENSRNOG00000008300 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiB1WBU4 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010983

Structurei

3D structure databases

ProteinModelPortaliB1WBU4
SMRiB1WBU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 92BTBPROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi429 – 435Poly-Glu7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri282 – 304C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 333C2H2-type 2PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148950
HOGENOMiHOG000124661
InParanoidiB1WBU4
OMAiKYNYHPA
OrthoDBiEOG091G05WK
PhylomeDBiB1WBU4

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequencei

Sequence statusi: Complete.

B1WBU4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEISSHQSHL LEQLNEQRRQ DVFCDCSILV EGKVFKAHRN VLFASSGYFK
60 70 80 90 100
MLLSQNSKET SQPTTATFQT FSPDTFTVIL DFVYSGKLSL TGQNVIEVMS
110 120 130 140 150
AASFLQMTDV ISVCKTFIKS SLDISEKEKD RYFSLSDKDT GSNGVERPSV
160 170 180 190 200
YSSSWQEDGG SPRSHLSPDQ GPAIVSGKPW NKYSYHPASQ RSPQPPLAKH
210 220 230 240 250
EQRKDPIKKT KHLRLPQPSE VVHFKSGKGD ARTSDSGHHV SQSEEQVQVD
260 270 280 290 300
AEVDPVSAGY PYSQGPEVAS RSFPDNLPRL RFKCPYCTHV VKRKADLKRH
310 320 330 340 350
LRCHTGERPY PCQACGKRFS RLDHLSSHFR TIHQACKLIC RKCKRHVTDL
360 370 380 390 400
TGQVVQEGTR RYRLCNECLT EVGMDSLPAD LETEQHRVSP ADGDKDCRWH
410 420 430 440
LSEEENRSYV EIVEDGSADL VIQQVDDSEE EEEKEIKPNI R
Length:441
Mass (Da):49,945
Last modified:May 20, 2008 - v1
Checksum:i15655FAA7E99D15E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161892 mRNA Translation: AAI61892.1
RefSeqiXP_006238993.1, XM_006238931.3
UniGeneiRn.82564

Genome annotation databases

EnsembliENSRNOT00000010983; ENSRNOP00000010983; ENSRNOG00000008300
GeneIDi313049

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161892 mRNA Translation: AAI61892.1
RefSeqiXP_006238993.1, XM_006238931.3
UniGeneiRn.82564

3D structure databases

ProteinModelPortaliB1WBU4
SMRiB1WBU4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010983

PTM databases

iPTMnetiB1WBU4
PhosphoSitePlusiB1WBU4

Proteomic databases

PaxDbiB1WBU4
PRIDEiB1WBU4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010983; ENSRNOP00000010983; ENSRNOG00000008300
GeneIDi313049

Organism-specific databases

CTDi653121
RGDi1308756 Zbtb8a

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000148950
HOGENOMiHOG000124661
InParanoidiB1WBU4
OMAiKYNYHPA
OrthoDBiEOG091G05WK
PhylomeDBiB1WBU4

Miscellaneous databases

PROiPR:B1WBU4

Gene expression databases

BgeeiENSRNOG00000008300 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiB1WBU4 RN

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT8A_RAT
AccessioniPrimary (citable) accession number: B1WBU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: May 20, 2008
Last modified: October 10, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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