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UniProtKB - B1WBU2 (B1WBU2_RAT)
Protein
Submitted name:
LOC682033 protein
Gene
Ppp2r3b
Organism
Rattus norvegicus (Rat)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 332 – 343 | PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 406 – 417 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium-dependent protein serine/threonine phosphatase activity Source: RGD
- calcium ion binding Source: InterPro
- chromatin binding Source: RGD
- protein phosphatase regulator activity Source: RGD
GO - Biological processi
- negative regulation of cell population proliferation Source: RGD
- negative regulation of G1/S transition of mitotic cell cycle Source: RGD
- protein dephosphorylation Source: RGD
Keywordsi
Ligand | CalciumPROSITE-ProRule annotation, Metal-bindingPROSITE-ProRule annotation |
Enzyme and pathway databases
Reactomei | R-RNO-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-RNO-69231, Cyclin D associated events in G1 R-RNO-69273, Cyclin A/B1/B2 associated events during G2/M transition |
Names & Taxonomyi
Protein namesi | Submitted name: LOC682033 proteinImportedSubmitted name: Protein phosphatase 2, regulatory subunit B'', betaImported |
Gene namesi | |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1588134, Ppp2r3b |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000049270, Expressed in testis and 20 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 328 – 354 | EF-handInterPro annotationAdd BLAST | 27 | |
Domaini | 393 – 428 | EF-handInterPro annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 125 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 520 – 552 | DisorderedSequence analysisAdd BLAST | 33 |
Phylogenomic databases
eggNOGi | KOG2562, Eukaryota |
GeneTreei | ENSGT00940000163491 |
HOGENOMi | CLU_019589_3_0_1 |
OMAi | CNYLVQD |
OrthoDBi | 255081at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR041534, EF-hand_13 IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF17958, EF-hand_13, 1 hit PF13499, EF-hand_7, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits |
i Sequence
Sequence statusi: Complete.
B1WBU2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPRKPPPSP LRPCLQMKVD ELFLRWLSDP GTQRALRAGL RRIQGPAVIL
60 70 80 90 100
DHTVTPNPAT ALDSATKAIA APAKIAPPDP AVTPNPAAIA SSTAITKFSA
110 120 130 140 150
SRKRNRHRAV PPRGEEPGPK APLPGRGIPA FYFPRGRPGQ GPDVDDVIAD
160 170 180 190 200
VERAFARLPS GRAGLQDMGV VAKACCCPLY WKAPLFLAAG GGAQGGFVSA
210 220 230 240 250
RDIIGLWKPI LLTCHDEAAR FERLLGGPGD GGLSPEDLAP LVQDVADSHP
260 270 280 290 300
GLSFLREAEP LRRDYVTTVT QRVFYAVNRS WSGRISCQEI RRSCFLQAVS
310 320 330 340 350
QLEAEPNPGR ATPSFFSYPH FCVIVSKFQA LDADGDGLID RHDLRRHADG
360 370 380 390 400
AISSRMIDRI FSGAVTRARP SPEGGKMGLA DFVWFLLSEE DKTTPTSTEY
410 420 430 440 450
WFRCMDLDGD GVLSAPELSF FYEEQAQNLA ARGAEPPPFA DLTRQALDLV
460 470 480 490 500
QPRCPGQITL GDLKRCGLAG EFFDAFFNAD KFLEHERREP AGPVRAPDAD
510 520 530 540 550
PTLSDWDRFA AAEYDFLLAE EAQDDDAWEE GSESPPSSPD PYDFADDTLD
PL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07014122 Genomic DNA No translation available. BC161890 mRNA Translation: AAI61890.1 |
RefSeqi | NP_001132964.1, NM_001139492.1 |
Genome annotation databases
Ensembli | ENSRNOT00000071648; ENSRNOP00000065433; ENSRNOG00000049270 |
GeneIDi | 682033 |
KEGGi | rno:682033 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07014122 Genomic DNA No translation available. BC161890 mRNA Translation: AAI61890.1 |
RefSeqi | NP_001132964.1, NM_001139492.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000065433 |
Genome annotation databases
Ensembli | ENSRNOT00000071648; ENSRNOP00000065433; ENSRNOG00000049270 |
GeneIDi | 682033 |
KEGGi | rno:682033 |
Organism-specific databases
CTDi | 28227 |
RGDi | 1588134, Ppp2r3b |
Phylogenomic databases
eggNOGi | KOG2562, Eukaryota |
GeneTreei | ENSGT00940000163491 |
HOGENOMi | CLU_019589_3_0_1 |
OMAi | CNYLVQD |
OrthoDBi | 255081at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-113501, Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-RNO-69231, Cyclin D associated events in G1 R-RNO-69273, Cyclin A/B1/B2 associated events during G2/M transition |
Gene expression databases
Bgeei | ENSRNOG00000049270, Expressed in testis and 20 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR041534, EF-hand_13 IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF17958, EF-hand_13, 1 hit PF13499, EF-hand_7, 1 hit |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | B1WBU2_RAT | |
Accessioni | B1WBU2Primary (citable) accession number: B1WBU2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | January 19, 2022 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |