Zbtb42

Functionⁱ

Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	292 – 314	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	332 – 354	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	360 – 382	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	388 – 411	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
muscle organ development Source: UniProtKB
negative regulation of transcription by RNA polymerase II Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and BTB domain-containing protein 42
Gene namesⁱ	Name:Zbtb42
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 6

Organism-specific databases

Rat genome database More...RGDⁱ	1582758 Zbtb42

RGDⁱ

1582758 Zbtb42

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000343712	1 – 420	Zinc finger and BTB domain-containing protein 42Add BLAST		420

Proteomic databases

PaxDbⁱ	B1WBS3
PRIDEⁱ	B1WBS3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000037562 Expressed in 9 organ(s), highest expression level in testis

Bgeeⁱ

ENSRNOG00000037562 Expressed in 9 organ(s), highest expression level in testis

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000035859

STRINGⁱ

10116.ENSRNOP00000035859

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B1WBS3
SMRⁱ	B1WBS3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 92	BTBPROSITE-ProRule annotationAdd BLAST		69

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	292 – 314	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	332 – 354	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	360 – 382	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	388 – 411	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150831
HOGENOMⁱ	HOG000234147
HOVERGENⁱ	HBG059113
InParanoidⁱ	B1WBS3
OMAⁱ	YEGRMEF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A78
PhylomeDBⁱ	B1WBS3
TreeFamⁱ	TF337437

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

B1WBS3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEFPEHGVRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH 
        60         70         80         90        100
LFYRDQPASS RDTVRLNGDI VTVPAFSRLL DFMYEGRLDL HSLPVEDVLA 
       110        120        130        140        150
AASYLHMYDI VKVCKGRLRK KDPDLETRTL GTELPGQTPH PLPSWPPAFC 
       160        170        180        190        200
QATPKAKPPS LGVKAVHPLP KFGPPSWQVS EESSGALDLS LKPGPRPEQA 
       210        220        230        240        250
HPPCLLQTSQ CSSIQQGAQP LVKAEQDSFS EQDSSSPQSA DRSPPPVCAS 
       260        270        280        290        300
AARGLAVNLE PLHIQGTGSQ QLGLHAEPVV DSEDLGPGRH LCICPLCCKL 
       310        320        330        340        350
FPSTHALQPH LSAHFRERDS VRTRLSPEGA VPTCPLCSKT FSCTYTLKRH 
       360        370        380        390        400
ERTHSGEKPY TCVQCGKSFQ YSHNLSRHAV VHTREKPHAC RWCERRFTQS 
       410        420
GDLYRHVRKF HYGLVKPLLV

Length:420

Mass (Da):46,628

Last modified:May 20, 2008 - v1

Checksum:ⁱ4FFA4279B16B1EF5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC161864 mRNA Translation: AAI61864.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001119774.1, NM_001126302.1
UniGeneⁱ	Rn.190797

Genome annotation databases

Ensemblⁱ	ENSRNOT00000030879; ENSRNOP00000035859; ENSRNOG00000037562
GeneIDⁱ	691556
KEGGⁱ	rno:691556
UCSC genome browser More...UCSCⁱ	RGD:1582758 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
B1WBS3	Zinc finger and BTB domain-containing protein 42		MOUSE		420	UniRef90_Q811H0
Uncharacterized protein		NEOLE		435
zinc finger and BTB domain-containing protein 42		MESAU		420
UPI00042AB8D9		PERMB		420
UPI000A307070		MUSPA		420
+8

Protein	Similar proteins		Species	Score	Length	Source
B1WBS3	Zinc finger and BTB domain-containing protein 42		MOUSE		420	UniRef50_Q811H0
Uncharacterized protein		NEOLE		435
zinc finger and BTB domain-containing protein 42		MESAU		420
Zinc finger and BTB domain-containing protein 42 (Fragment)		TUPCH		352
UPI000A316349		MUSCR		420
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC161864 mRNA Translation: AAI61864.1
RefSeqⁱ	NP_001119774.1, NM_001126302.1
UniGeneⁱ	Rn.190797

3D structure databases

ProteinModelPortalⁱ	B1WBS3
SMRⁱ	B1WBS3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000035859

STRINGⁱ

10116.ENSRNOP00000035859

Proteomic databases

PaxDbⁱ	B1WBS3
PRIDEⁱ	B1WBS3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000030879; ENSRNOP00000035859; ENSRNOG00000037562
GeneIDⁱ	691556
KEGGⁱ	rno:691556
UCSCⁱ	RGD:1582758 rat

Organism-specific databases

CTDⁱ	100128927
RGDⁱ	1582758 Zbtb42

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00930000150831
HOGENOMⁱ	HOG000234147
HOVERGENⁱ	HBG059113
InParanoidⁱ	B1WBS3
OMAⁱ	YEGRMEF
OrthoDBⁱ	EOG091G0A78
PhylomeDBⁱ	B1WBS3
TreeFamⁱ	TF337437

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:B1WBS3

PROⁱ

PR:B1WBS3

Gene expression databases

Bgeeⁱ	ENSRNOG00000037562 Expressed in 9 organ(s), highest expression level in testis

Bgeeⁱ

ENSRNOG00000037562 Expressed in 9 organ(s), highest expression level in testis

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00651 BTB, 1 hit PF00096 zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF54695 SSF54695, 1 hit SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS50097 BTB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZBT42_RAT
Accessionⁱ	B1WBS3Primary (citable) accession number: B1WBS3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
	Last sequence update:	May 20, 2008
	Last modified:	November 7, 2018
	This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - B1WBS3 (ZBT42_RAT)

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Zinc finger and BTB domain-containing protein 42

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ