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Protein

Zinc finger and BTB domain-containing protein 42

Gene

Zbtb42

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri292 – 314C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 411C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 42
Gene namesi
Name:Zbtb42
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1582758 Zbtb42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003437121 – 420Zinc finger and BTB domain-containing protein 42Add BLAST420

Proteomic databases

PaxDbiB1WBS3
PRIDEiB1WBS3

Expressioni

Gene expression databases

BgeeiENSRNOG00000037562 Expressed in 9 organ(s), highest expression level in testis

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035859

Structurei

3D structure databases

ProteinModelPortaliB1WBS3
SMRiB1WBS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 92BTBPROSITE-ProRule annotationAdd BLAST69

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri292 – 314C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri332 – 354C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri360 – 382C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri388 – 411C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150831
HOGENOMiHOG000234147
HOVERGENiHBG059113
InParanoidiB1WBS3
OMAiYEGRMEF
OrthoDBiEOG091G0A78
PhylomeDBiB1WBS3
TreeFamiTF337437

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

B1WBS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFPEHGVRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH
60 70 80 90 100
LFYRDQPASS RDTVRLNGDI VTVPAFSRLL DFMYEGRLDL HSLPVEDVLA
110 120 130 140 150
AASYLHMYDI VKVCKGRLRK KDPDLETRTL GTELPGQTPH PLPSWPPAFC
160 170 180 190 200
QATPKAKPPS LGVKAVHPLP KFGPPSWQVS EESSGALDLS LKPGPRPEQA
210 220 230 240 250
HPPCLLQTSQ CSSIQQGAQP LVKAEQDSFS EQDSSSPQSA DRSPPPVCAS
260 270 280 290 300
AARGLAVNLE PLHIQGTGSQ QLGLHAEPVV DSEDLGPGRH LCICPLCCKL
310 320 330 340 350
FPSTHALQPH LSAHFRERDS VRTRLSPEGA VPTCPLCSKT FSCTYTLKRH
360 370 380 390 400
ERTHSGEKPY TCVQCGKSFQ YSHNLSRHAV VHTREKPHAC RWCERRFTQS
410 420
GDLYRHVRKF HYGLVKPLLV
Length:420
Mass (Da):46,628
Last modified:May 20, 2008 - v1
Checksum:i4FFA4279B16B1EF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161864 mRNA Translation: AAI61864.1
RefSeqiNP_001119774.1, NM_001126302.1
UniGeneiRn.190797

Genome annotation databases

EnsembliENSRNOT00000030879; ENSRNOP00000035859; ENSRNOG00000037562
GeneIDi691556
KEGGirno:691556
UCSCiRGD:1582758 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC161864 mRNA Translation: AAI61864.1
RefSeqiNP_001119774.1, NM_001126302.1
UniGeneiRn.190797

3D structure databases

ProteinModelPortaliB1WBS3
SMRiB1WBS3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035859

Proteomic databases

PaxDbiB1WBS3
PRIDEiB1WBS3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000030879; ENSRNOP00000035859; ENSRNOG00000037562
GeneIDi691556
KEGGirno:691556
UCSCiRGD:1582758 rat

Organism-specific databases

CTDi100128927
RGDi1582758 Zbtb42

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150831
HOGENOMiHOG000234147
HOVERGENiHBG059113
InParanoidiB1WBS3
OMAiYEGRMEF
OrthoDBiEOG091G0A78
PhylomeDBiB1WBS3
TreeFamiTF337437

Miscellaneous databases

PROiPR:B1WBS3

Gene expression databases

BgeeiENSRNOG00000037562 Expressed in 9 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT42_RAT
AccessioniPrimary (citable) accession number: B1WBS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 20, 2008
Last modified: November 7, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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