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UniProtKB - B1WBS3 (ZBT42_RAT)
Protein
Zinc finger and BTB domain-containing protein 42
Gene
Zbtb42
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 292 – 314 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 332 – 354 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 360 – 382 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 388 – 411 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- muscle organ development Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 42 |
Gene namesi | Name:Zbtb42 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1582758, Zbtb42 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- nucleoplasm By similarity
Nucleus
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000343712 | 1 – 420 | Zinc finger and BTB domain-containing protein 42Add BLAST | 420 |
Proteomic databases
PaxDbi | B1WBS3 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000037562, Expressed in testis and 20 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 92 | BTBPROSITE-ProRule annotationAdd BLAST | 69 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 174 – 204 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 216 – 248 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 216 – 243 | Polar residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 292 – 314 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 332 – 354 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 360 – 382 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 388 – 411 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163959 |
HOGENOMi | CLU_034521_0_0_1 |
InParanoidi | B1WBS3 |
OMAi | PCILQTP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | B1WBS3 |
TreeFami | TF337437 |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
i Sequence
Sequence statusi: Complete.
B1WBS3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEFPEHGVRL LGRLRQQREL GFLCDCTVLV GDARFPAHRA VLAACSVYFH
60 70 80 90 100
LFYRDQPASS RDTVRLNGDI VTVPAFSRLL DFMYEGRLDL HSLPVEDVLA
110 120 130 140 150
AASYLHMYDI VKVCKGRLRK KDPDLETRTL GTELPGQTPH PLPSWPPAFC
160 170 180 190 200
QATPKAKPPS LGVKAVHPLP KFGPPSWQVS EESSGALDLS LKPGPRPEQA
210 220 230 240 250
HPPCLLQTSQ CSSIQQGAQP LVKAEQDSFS EQDSSSPQSA DRSPPPVCAS
260 270 280 290 300
AARGLAVNLE PLHIQGTGSQ QLGLHAEPVV DSEDLGPGRH LCICPLCCKL
310 320 330 340 350
FPSTHALQPH LSAHFRERDS VRTRLSPEGA VPTCPLCSKT FSCTYTLKRH
360 370 380 390 400
ERTHSGEKPY TCVQCGKSFQ YSHNLSRHAV VHTREKPHAC RWCERRFTQS
410 420
GDLYRHVRKF HYGLVKPLLV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC161864 mRNA Translation: AAI61864.1 |
RefSeqi | NP_001119774.1, NM_001126302.1 |
Genome annotation databases
Ensembli | ENSRNOT00000030879; ENSRNOP00000035859; ENSRNOG00000037562 |
GeneIDi | 691556 |
KEGGi | rno:691556 |
UCSCi | RGD:1582758, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC161864 mRNA Translation: AAI61864.1 |
RefSeqi | NP_001119774.1, NM_001126302.1 |
3D structure databases
SMRi | B1WBS3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000035859 |
Proteomic databases
PaxDbi | B1WBS3 |
Genome annotation databases
Ensembli | ENSRNOT00000030879; ENSRNOP00000035859; ENSRNOG00000037562 |
GeneIDi | 691556 |
KEGGi | rno:691556 |
UCSCi | RGD:1582758, rat |
Organism-specific databases
CTDi | 100128927 |
RGDi | 1582758, Zbtb42 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163959 |
HOGENOMi | CLU_034521_0_0_1 |
InParanoidi | B1WBS3 |
OMAi | PCILQTP |
OrthoDBi | 1318335at2759 |
PhylomeDBi | B1WBS3 |
TreeFami | TF337437 |
Miscellaneous databases
PROi | PR:B1WBS3 |
Gene expression databases
Bgeei | ENSRNOG00000037562, Expressed in testis and 20 other tissues |
Family and domain databases
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 2 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT42_RAT | |
Accessioni | B1WBS3Primary (citable) accession number: B1WBS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | September 29, 2021 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families