Stk3

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: Ensembl
identical protein binding Source: Ensembl
magnesium ion binding Source: Ensembl
protein serine/threonine kinase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation involved in embryonic placenta development Source: Ensembl
central nervous system development Source: Ensembl
endocardium development Source: Ensembl
hepatocyte apoptotic process Source: Ensembl
hippo signaling Source: Ensembl
negative regulation of canonical Wnt signaling pathway Source: Ensembl
negative regulation of cell proliferation Source: Ensembl
negative regulation of organ growth Source: Ensembl
neural tube formation Source: Ensembl
positive regulation of DNA-binding transcription factor activity Source: Ensembl
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
positive regulation of fat cell differentiation Source: Ensembl
positive regulation of JNK cascade Source: Ensembl
positive regulation of protein binding Source: Ensembl
positive regulation of protein kinase B signaling Source: Ensembl
primitive hemopoiesis Source: Ensembl
protein stabilization Source: Ensembl
regulation of cell differentiation involved in embryonic placenta development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	KinaseImported, Transferase

Molecular function

KinaseImported, Transferase

Enzyme and pathway databases

Reactomeⁱ	R-RNO-2028269 Signaling by Hippo

Reactomeⁱ

R-RNO-2028269 Signaling by Hippo

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Serine/threonine kinase 3 (STE20 homolog, yeast)Imported Submitted name: Serine/threonine-protein kinase 3Imported
Gene namesⁱ	Name:Stk3Imported ORF Names:rCG_60292Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 7

Organism-specific databases

Rat genome database More...RGDⁱ	68412 Stk3

RGDⁱ

68412 Stk3

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000011278 Expressed in 10 organ(s), highest expression level in colon

Bgeeⁱ

ENSRNOG00000011278 Expressed in 10 organ(s), highest expression level in colon

Interactionⁱ

GO - Molecular functionⁱ

identical protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 278	Protein kinaseInterPro annotationAdd BLAST		252
Domainⁱ	437 – 484	SARAHInterPro annotationAdd BLAST		48

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	292 – 322	Sequence analysisAdd BLAST		31

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG0201 Eukaryota ENOG410XP9G LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149000
HOVERGENⁱ	HBG108518
OMAⁱ	KQDSKLK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G065P
TreeFamⁱ	TF354217

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR024205 Mst1_SARAH_domain IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR011524 SARAH_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11629 Mst1_SARAH, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS50951 SARAH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

B1WBQ5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG 
        60         70         80         90        100
QVVAIKQVPV ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME 
       110        120        130        140        150
YCGAGSVSDI IRLRNKTLTE DEIATILKST LKGLEYLHFM RKIHRDIKAG 
       160        170        180        190        200
NILLNTEGHA KLADFGVAGQ LTDTMAKRNT VIGTPFWMAP EVIQEIGYNC 
       210        220        230        240        250
VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT FRKPELWSDD 
       260        270        280        290        300
FTDFVKKCLV KSPEQRATAT QLLQHPFIKN AKPVSILREL ITEGMEIKAK 
       310        320        330        340        350
RHEEQQRELE DEEENSDEDE LDSHTMVKTS SEGVGTMRAT STMSEGAQTM 
       360        370        380        390        400
IEHNSTMLES DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ 
       410        420        430        440        450
DFKNKSHENC DQSMREPCPM SNNVFPDNWR VPQDGDFDFL KNLSLEELQM 
       460        470        480        490 
RLKALDPMME REIEELHQRY SAKRQPILDA MDAKKRRQQN F

Length:491

Mass (Da):56,136

Last modified:May 20, 2008 - v1

Checksum:ⁱC7B4ED74E45456C2

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	O54748	STK3_RAT		Serine/threonine-protein kinase 3 Serine/threonine-protein kinase 3, EC 2.7.11.1 (Mammalian STE20-like protein kinase 2, MST-2) (STE20-like kinase MST2) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit, MST2/N; Serine/threonine-protein kinase 3 20kDa subunit, MST2/C]	Stk3 Mst2	491	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07057479 Genomic DNA No translation available. AABR07057480 Genomic DNA No translation available. AABR07057481 Genomic DNA No translation available. AABR07057482 Genomic DNA No translation available. AABR07073316 Genomic DNA No translation available. AC134134 Genomic DNA No translation available. AC136386 Genomic DNA No translation available. BC161844 mRNA Translation: AAI61844.1 CH473950 Genomic DNA Translation: EDM16411.1
UniGeneⁱ	Rn.89363

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AABR07057479 Genomic DNA No translation available.
AABR07057480 Genomic DNA No translation available.
AABR07057481 Genomic DNA No translation available.
AABR07057482 Genomic DNA No translation available.
AABR07073316 Genomic DNA No translation available.
AC134134 Genomic DNA No translation available.
AC136386 Genomic DNA No translation available.
BC161844 mRNA Translation: AAI61844.1
CH473950 Genomic DNA Translation: EDM16411.1

UniGeneⁱ

Rn.89363

Genome annotation databases

Ensemblⁱ	ENSRNOT00000065722; ENSRNOP00000062778; ENSRNOG00000011278

Ensemblⁱ

ENSRNOT00000065722; ENSRNOP00000062778; ENSRNOG00000011278

Protein	Similar proteins		Species	Score	Length	Source
B1WBQ5	Serine/threonine-protein kinase 3	)	HUMAN		491	UniRef90_Q13188
Serine/threonine-protein kinase 3		XENLA		493
Serine/threonine-protein kinase 3		RAT		491
LOC100036637 protein		XENTR		493
Uncharacterized protein		Cebus capucinus imitator		491
+88

Protein	Similar proteins		Species	Score	Length	Source
B1WBQ5	Serine/threonine-protein kinase 3	)	HUMAN		491	UniRef50_Q13188
Serine/threonine-protein kinase 3		XENLA		493
Serine/threonine-protein kinase 3		RAT		491
Serine/threonine-protein kinase 3		DANRE		492
Serine/threonine-protein kinase 3		MOUSE		497
+594

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07057479 Genomic DNA No translation available. AABR07057480 Genomic DNA No translation available. AABR07057481 Genomic DNA No translation available. AABR07057482 Genomic DNA No translation available. AABR07073316 Genomic DNA No translation available. AC134134 Genomic DNA No translation available. AC136386 Genomic DNA No translation available. BC161844 mRNA Translation: AAI61844.1 CH473950 Genomic DNA Translation: EDM16411.1
UniGeneⁱ	Rn.89363

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AABR07057479 Genomic DNA No translation available.
AABR07057480 Genomic DNA No translation available.
AABR07057481 Genomic DNA No translation available.
AABR07057482 Genomic DNA No translation available.
AABR07073316 Genomic DNA No translation available.
AC134134 Genomic DNA No translation available.
AC136386 Genomic DNA No translation available.
BC161844 mRNA Translation: AAI61844.1
CH473950 Genomic DNA Translation: EDM16411.1

UniGeneⁱ

Rn.89363

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000065722; ENSRNOP00000062778; ENSRNOG00000011278

Ensemblⁱ

ENSRNOT00000065722; ENSRNOP00000062778; ENSRNOG00000011278

Organism-specific databases

RGDⁱ	68412 Stk3

Phylogenomic databases

eggNOGⁱ	KOG0201 Eukaryota ENOG410XP9G LUCA
GeneTreeⁱ	ENSGT00920000149000
HOVERGENⁱ	HBG108518
OMAⁱ	KQDSKLK
OrthoDBⁱ	EOG091G065P
TreeFamⁱ	TF354217

Enzyme and pathway databases

Reactomeⁱ	R-RNO-2028269 Signaling by Hippo

Reactomeⁱ

R-RNO-2028269 Signaling by Hippo

Gene expression databases

Bgeeⁱ	ENSRNOG00000011278 Expressed in 10 organ(s), highest expression level in colon

Bgeeⁱ

ENSRNOG00000011278 Expressed in 10 organ(s), highest expression level in colon

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR024205 Mst1_SARAH_domain IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR011524 SARAH_dom
Pfamⁱ	View protein in Pfam PF11629 Mst1_SARAH, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS50951 SARAH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B1WBQ5_RAT
Accessionⁱ	B1WBQ5Primary (citable) accession number: B1WBQ5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 20, 2008
	Last sequence update:	May 20, 2008
	Last modified:	September 12, 2018
	This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - B1WBQ5 (B1WBQ5_RAT)

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Serine/threonine kinase 3 (STE20 homolog, yeast)

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ