We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - B1WBQ5 (B1WBQ5_RAT)
Protein
Non-specific serine/threonine protein kinase
Gene
Stk3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
Cofactori
Mg2+ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 56 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- identical protein binding Source: Ensembl
- magnesium ion binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB-KW
- protein serine kinase activity Source: RHEA
GO - Biological processi
- cell differentiation involved in embryonic placenta development Source: Ensembl
- central nervous system development Source: Ensembl
- endocardium development Source: Ensembl
- hepatocyte apoptotic process Source: Ensembl
- hippo signaling Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of organ growth Source: Ensembl
- neural tube formation Source: Ensembl
- positive regulation of DNA-binding transcription factor activity Source: Ensembl
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
- positive regulation of fat cell differentiation Source: Ensembl
- positive regulation of JNK cascade Source: Ensembl
- positive regulation of protein binding Source: Ensembl
- positive regulation of protein kinase B signaling Source: Ensembl
- primitive hemopoiesis Source: Ensembl
- protein import into nucleus Source: Ensembl
- protein stabilization Source: Ensembl
- protein tetramerization Source: InterPro
- regulation of cell differentiation involved in embryonic placenta development Source: Ensembl
Keywordsi
Molecular function | KinaseImportedARBA annotation, Transferase |
Biological process | ApoptosisARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:Stk3Imported ORF Names:rCG_60292Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 68412, Stk3 |
Subcellular locationi
Nucleus
- nucleus Source: Ensembl
Other locations
- cytoplasm Source: Ensembl
- protein-containing complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000011278, Expressed in female gonad and 22 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
IntActi | B1WBQ5, 2 interactors |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 278 | Protein kinaseInterPro annotationAdd BLAST | 252 | |
Domaini | 437 – 484 | SARAHInterPro annotationAdd BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 301 – 343 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 370 – 392 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 327 – 343 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.ARBA annotation
Keywords - Domaini
Coiled coilARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000154984 |
HOGENOMi | CLU_000288_63_23_1 |
OMAi | QRMANLD |
TreeFami | TF354217 |
Family and domain databases
Gene3Di | 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024205, Mst1_SARAH_domain IPR036674, p53_tetramer_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR011524, SARAH_dom |
Pfami | View protein in Pfam PF11629, Mst1_SARAH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS50951, SARAH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B1WBQ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQPPAPKSK LKKLSEDSLT KQPEEVFDVL EKLGEGSYGS VFKAIHKESG
60 70 80 90 100
QVVAIKQVPV ESDLQEIIKE ISIMQQCDSP YVVKYYGSYF KNTDLWIVME
110 120 130 140 150
YCGAGSVSDI IRLRNKTLTE DEIATILKST LKGLEYLHFM RKIHRDIKAG
160 170 180 190 200
NILLNTEGHA KLADFGVAGQ LTDTMAKRNT VIGTPFWMAP EVIQEIGYNC
210 220 230 240 250
VADIWSLGIT SIEMAEGKPP YADIHPMRAI FMIPTNPPPT FRKPELWSDD
260 270 280 290 300
FTDFVKKCLV KSPEQRATAT QLLQHPFIKN AKPVSILREL ITEGMEIKAK
310 320 330 340 350
RHEEQQRELE DEEENSDEDE LDSHTMVKTS SEGVGTMRAT STMSEGAQTM
360 370 380 390 400
IEHNSTMLES DLGTMVINSE DEEEEDGTMK RNATSPQVQR PSFMDYFDKQ
410 420 430 440 450
DFKNKSHENC DQSMREPCPM SNNVFPDNWR VPQDGDFDFL KNLSLEELQM
460 470 480 490
RLKALDPMME REIEELHQRY SAKRQPILDA MDAKKRRQQN F
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketO54748 | STK3_RAT | Serine/threonine-protein kinase 3 | Stk3 Mst2 | 491 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07057479 Genomic DNA No translation available. AABR07057480 Genomic DNA No translation available. AABR07057481 Genomic DNA No translation available. AABR07057482 Genomic DNA No translation available. AABR07073316 Genomic DNA No translation available. AC134134 Genomic DNA No translation available. AC136386 Genomic DNA No translation available. BC161844 mRNA Translation: AAI61844.1 CH473950 Genomic DNA Translation: EDM16411.1 |
RefSeqi | NP_113923.1, NM_031735.1 |
Genome annotation databases
Ensembli | ENSRNOT00000065722; ENSRNOP00000062778; ENSRNOG00000011278 |
GeneIDi | 65189 |
KEGGi | rno:65189 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07057479 Genomic DNA No translation available. AABR07057480 Genomic DNA No translation available. AABR07057481 Genomic DNA No translation available. AABR07057482 Genomic DNA No translation available. AABR07073316 Genomic DNA No translation available. AC134134 Genomic DNA No translation available. AC136386 Genomic DNA No translation available. BC161844 mRNA Translation: AAI61844.1 CH473950 Genomic DNA Translation: EDM16411.1 |
RefSeqi | NP_113923.1, NM_031735.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B1WBQ5, 2 interactors |
Genome annotation databases
Ensembli | ENSRNOT00000065722; ENSRNOP00000062778; ENSRNOG00000011278 |
GeneIDi | 65189 |
KEGGi | rno:65189 |
Organism-specific databases
CTDi | 6788 |
RGDi | 68412, Stk3 |
Phylogenomic databases
GeneTreei | ENSGT00940000154984 |
HOGENOMi | CLU_000288_63_23_1 |
OMAi | QRMANLD |
TreeFami | TF354217 |
Gene expression databases
Bgeei | ENSRNOG00000011278, Expressed in female gonad and 22 other tissues |
Family and domain databases
Gene3Di | 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR024205, Mst1_SARAH_domain IPR036674, p53_tetramer_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR011524, SARAH_dom |
Pfami | View protein in Pfam PF11629, Mst1_SARAH, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS50951, SARAH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B1WBQ5_RAT | |
Accessioni | B1WBQ5Primary (citable) accession number: B1WBQ5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | January 19, 2022 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |