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UniProtKB - B1WBL8 (B1WBL8_RAT)
Protein
Angiotensin II type-2 receptor
Gene
Agtr2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
ARBA annotationGO - Molecular functioni
- angiotensin type II receptor activity Source: Ensembl
GO - Biological processi
- angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: Ensembl
- brain renin-angiotensin system Source: Ensembl
- exploration behavior Source: Ensembl
- G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: Ensembl
- inflammatory response Source: Ensembl
- intracellular signal transduction Source: Ensembl
- negative regulation of heart rate Source: Ensembl
- positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
- positive regulation of metanephric glomerulus development Source: Ensembl
- positive regulation of nitric-oxide synthase activity Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- regulation of apoptotic process Source: InterPro
- regulation of metanephros size Source: Ensembl
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Angiotensin II type-2 receptorARBA annotationAlternative name(s): Type-2 angiotensin II receptorARBA annotation |
Gene namesi | Name:Agtr2Imported ORF Names:rCG_53260Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Organism-specific databases
RGDi | 2072, Agtr2 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 49 – 70 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 82 – 100 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 120 – 140 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 160 – 181 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 217 – 234 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 254 – 278 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 298 – 321 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSRNOG00000050006, Expressed in esophagus and 12 other tissues |
Interactioni
Subunit structurei
Interacts with MTUS1.
ARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 318 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 258 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_8_3_1 |
OMAi | ESTFNCS |
OrthoDBi | 685818at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000147, ATII_AT2_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00636, ANGIOTENSN2R PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
B1WBL8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDNFSFAAT SRNITSSLPF DNLNATGTNE SAFNCSHKPA DKHLEAIPVL
60 70 80 90 100
YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW
110 120 130 140 150
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF
160 170 180 190 200
LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP
210 220 230 240 250
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT
260 270 280 290 300
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL
310 320 330 340 350
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR
360
KSSSLREMDT FVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC161802 mRNA Translation: AAI61802.1 CH473991 Genomic DNA Translation: EDM10788.1 CH473991 Genomic DNA Translation: EDM10789.1 |
RefSeqi | NP_036626.1, NM_012494.3 XP_006257494.1, XM_006257432.3 |
Genome annotation databases
GeneIDi | 24182 |
KEGGi | rno:24182 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC161802 mRNA Translation: AAI61802.1 CH473991 Genomic DNA Translation: EDM10788.1 CH473991 Genomic DNA Translation: EDM10789.1 |
RefSeqi | NP_036626.1, NM_012494.3 XP_006257494.1, XM_006257432.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
GeneIDi | 24182 |
KEGGi | rno:24182 |
Organism-specific databases
CTDi | 186 |
RGDi | 2072, Agtr2 |
Phylogenomic databases
HOGENOMi | CLU_009579_8_3_1 |
OMAi | ESTFNCS |
OrthoDBi | 685818at2759 |
Gene expression databases
Bgeei | ENSRNOG00000050006, Expressed in esophagus and 12 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000147, ATII_AT2_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00636, ANGIOTENSN2R PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B1WBL8_RAT | |
Accessioni | B1WBL8Primary (citable) accession number: B1WBL8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | January 19, 2022 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |