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Protein

Thymidine kinase

Gene

tdk

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi86 – 89ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:SGR_1680Imported
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)Imported
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001685 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi455632.SGR_1680

Structurei

3D structure databases

ProteinModelPortaliB1VXP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107W53 Bacteria
COG1435 LUCA
HOGENOMiHOG000076391
KOiK00857
OMAiRATHNAR

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

B1VXP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPELVFFSGT MDCGKSTLAL QIGHNRSARG LQGVIFTRDD RAGEGKLSSR
60 70 80 90 100
LGLVTDAVEA EEGMDLYAHI VGRVSRGGRV DYVIVDEAQF LAPDQIDQLA
110 120 130 140 150
RVVDDLGLDV FAFGITTDFR TKLFPGSQRL IELADRIEAL QVEALCWCGA
160 170 180 190 200
RATHNARTVD GEMVVEGAQV VVGDVNRQAG EVGYEVLCRR HHRRRTTATA
210
ARASSLSPDV LPVASDA
Length:217
Mass (Da):23,513
Last modified:May 20, 2008 - v1
Checksum:iC4B8ACBF31371E02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA Translation: BAG18509.1
RefSeqiWP_003965745.1, NC_010572.1

Genome annotation databases

EnsemblBacteriaiBAG18509; BAG18509; SGR_1680
GeneIDi6213464
KEGGisgr:SGR_1680
PATRICifig|455632.4.peg.1702

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA Translation: BAG18509.1
RefSeqiWP_003965745.1, NC_010572.1

3D structure databases

ProteinModelPortaliB1VXP3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi455632.SGR_1680

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG18509; BAG18509; SGR_1680
GeneIDi6213464
KEGGisgr:SGR_1680
PATRICifig|455632.4.peg.1702

Phylogenomic databases

eggNOGiENOG4107W53 Bacteria
COG1435 LUCA
HOGENOMiHOG000076391
KOiK00857
OMAiRATHNAR

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1VXP3_STRGG
AccessioniPrimary (citable) accession number: B1VXP3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 18, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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