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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei731ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSGRI455632:G1G2X-5048-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SGR_4973
OrganismiStreptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
Taxonomic identifieri455632 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000001685 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913661 – 957Leucine--tRNA ligaseAdd BLAST957

Proteomic databases

PRIDEiB1VXF6

Interactioni

Protein-protein interaction databases

STRINGi455632.SGR_4973

Structurei

3D structure databases

ProteinModelPortaliB1VXF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 77"HIGH" regionAdd BLAST12
Motifi728 – 732"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 2 hits
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B1VXF6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSETNSAAET AAPHRYTAAM AADIEARWQD FWDAEGTYEA PNPTGDLAGD
60 70 80 90 100
PELAARPKKF IMDMFPYPSG AGLHVGHPLG YIATDVYARH QRMTGHNVLH
110 120 130 140 150
TLGFDAFGLP AEQYAVQTGT HPRVSTEANM ENMKVQLRRL GLGHDNRRSF
160 170 180 190 200
ATIDSEYYKW TQWIFLQIFN SWYDSEADRA RPIAELVEQF ENGTRATPDG
210 220 230 240 250
REWGALSAAE RADLLSEYRL AYASDAPVNW SPGLGTVLAN EEVTADGRSE
260 270 280 290 300
RGNFPVFKAK LRQWNMRITA YADRLLNDLD GLDWPEAIKL QQRNWIGRSE
310 320 330 340 350
GARVEFPVDT AGGITVFTTR QDTLFGATYM VLAPEHDMVE RIIPAAWPEG
360 370 380 390 400
THPVWTGGHA SPAEAVTAYR KQAAAKSDVE RQAEAKDKTG VFTGAYATNP
410 420 430 440 450
VSGEKVPVFI ADYVLMGYGT GAIMAVPAHD ARDFAFARAF ELPMRCVVQP
460 470 480 490 500
SDDRGTDPAT WDDAFSSYDA KLVNSANDEI SLDGLGVVEA KARITEWLKE
510 520 530 540 550
HGVGEGTVNF RLRDWLFSRQ RYWGEPFPIV YDEDGIAHPL PESMLPLELP
560 570 580 590 600
EVEDYSPRTF DPEDATAQPE TPLSRNADWV NVTLDLGDGA GPRKYRRETN
610 620 630 640 650
TMPNWAGSCW YELRYLDPNN DRQLVDPSIE QYWMGPREGQ PTGGVDLYVG
660 670 680 690 700
GAEHAVLHLL YARFWSKVLH DLGHISSAEP FHKLYNQGMI QAFVYRDSRG
710 720 730 740 750
IAVPAAEVEE RDGAFYHAGE KVSRVLGKMG KSLKNAVTPD EICAEYGADT
760 770 780 790 800
LRLYEMAMGP LDVSRPWDTR AVVGQYRLLQ RLWRNVVDEA TGEVTVVDTE
810 820 830 840 850
PDEDTLRALH KAIDGVGQDM AGMRFNTAIA KVTELNNHLT KAGGPLSRSV
860 870 880 890 900
AERLVLLIAP LAPHIAEELW RRLGHADSVV HQDFPVADPA YVVDETVTCV
910 920 930 940 950
VQIKGKVRAR LEISPAITDE ELEALALADE AVVAALGGAG IRKVIVRAPK

LVNIVPA
Length:957
Mass (Da):106,033
Last modified:May 20, 2008 - v1
Checksum:i1FF90F2A1C800FB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA Translation: BAG21802.1
RefSeqiWP_012381003.1, NC_010572.1

Genome annotation databases

EnsemblBacteriaiBAG21802; BAG21802; SGR_4973
GeneIDi6211000
KEGGisgr:SGR_4973
PATRICifig|455632.4.peg.5086

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009493 Genomic DNA Translation: BAG21802.1
RefSeqiWP_012381003.1, NC_010572.1

3D structure databases

ProteinModelPortaliB1VXF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi455632.SGR_4973

Proteomic databases

PRIDEiB1VXF6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG21802; BAG21802; SGR_4973
GeneIDi6211000
KEGGisgr:SGR_4973
PATRICifig|455632.4.peg.5086

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP

Enzyme and pathway databases

BioCyciSGRI455632:G1G2X-5048-MONOMER

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 2 hits
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYL_STRGG
AccessioniPrimary (citable) accession number: B1VXF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 20, 2008
Last modified: October 10, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
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Main funding by: National Institutes of Health

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