Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 100 (29 Sep 2021)
Sequence version 1 (29 Apr 2008)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Myosin heavy chain 11 smooth muscle isoform

Gene

MYH11

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi178 – 185ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationARBA annotation, Motor protein, MyosinPROSITE-ProRule annotationARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myosin heavy chain 11 smooth muscle isoformImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
B1PS43

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B1PS43

PeptideAtlas

More...
PeptideAtlasi
B1PS43

PRoteomics IDEntifications database

More...
PRIDEi
B1PS43

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3398

PTM databases

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
B1PS43

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B1PS43

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133392, Expressed in saphenous vein and 249 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 81Myosin N-terminal SH3-likeInterPro annotationAdd BLAST51
Domaini85 – 790Myosin motorInterPro annotationAdd BLAST706

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni668 – 690Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni865 – 889DisorderedSequence analysisAdd BLAST25
Regioni1751 – 1807DisorderedSequence analysisAdd BLAST57
Regioni1874 – 1951DisorderedSequence analysisAdd BLAST78
Regioni1979 – 2029DisorderedSequence analysisAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1187 – 1582Sequence analysisAdd BLAST396
Coiled coili1584 – 1726Sequence analysisAdd BLAST143

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1768 – 1794Polar residuesSequence analysisAdd BLAST27
Compositional biasi1874 – 1922Basic and acidic residuesSequence analysisAdd BLAST49
Compositional biasi2011 – 2029Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Phylogenomic databases

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B1PS43

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR002928, Myosin_tail
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063, Myosin_head, 1 hit
PF02736, Myosin_N, 1 hit
PF01576, Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015, IQ, 1 hit
SM00242, MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B1PS43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI
60 70 80 90 100
KEEKGDEVVV ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS
110 120 130 140 150
VLHNLRERYF SGLIYTYSGL FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM
160 170 180 190 200
PPHIYAIADT AYRSMLQDRE DQSILCTGES GAGKTENTKK VIQYLAVVAS
210 220 230 240 250
SHKGKKDTSI TEGPSFWRGE LEKQLLQANP ILEAFGNAKT VKNDNSSRFG
260 270 280 290 300
KFIRINFDVT GYIVGANIET YLLEKSRAIR QARDERTFHI FYYMIAGAKE
310 320 330 340 350
KMRSDLLLEG FNNYTFLSNG FVPIPAAQDD EMFQETVEAM AIMGFSEEEQ
360 370 380 390 400
LSILKVVSSV LQLGNIVFKK ERNTDQASMP DNTAAQKVCH LMGINVTDFT
410 420 430 440 450
RSILTPRIKV GRDVVQKAQT KEQADFAVEA LAKATYERLF RWILTRVNKA
460 470 480 490 500
LDKTHRQGAS FLGILDIAGF EIFEVNSFEQ LCINYTNEKL QQLFNHTMFI
510 520 530 540 550
LEQEEYQREG IEWNFIDFGL DLQPCIELIE RPNNPPGVLA LLDEECWFPK
560 570 580 590 600
ATDKSFVEKL CTEQGSHPKF QKPKQLKDKT EFSIIHYAGK VDYNASAWLT
610 620 630 640 650
KNMDPLNDNV TSLLNASSDK FVADLWKDVD RIVGLDQMAK MTESSLPSAS
660 670 680 690 700
KTKKGMFRTV GQLYKEQLGK LMTTLRNTTP NFVRCIIPNH EKRSGKLDAF
710 720 730 740 750
LVLEQLRCNG VLEGIRICRQ GFPNRIVFQE FRQRYEILAA NAIPKGFMDG
760 770 780 790 800
KQACILMIKA LELDPNLYRI GQSKIFFRTG VLAHLEEERD LKITDVIMAF
810 820 830 840 850
QAMCRGYLAR KAFAKRQQQL TAMKVIQRNC AAYLKLRNWQ WWRLFTKVKP
860 870 880 890 900
LLQVTRQEEE MQAKEDELQK TKERQQKAEN ELKELEQKHS QLTEEKNLLQ
910 920 930 940 950
EQLQAETELY AEAEEMRVRL AAKKQELEEI LHEMEARLEE EEDRGQQLQA
960 970 980 990 1000
ERKKMAQQML DLEEQLEEEE AARQKLQLEK VTAEAKIKKL EDEILVMDDQ
1010 1020 1030 1040 1050
NNKLSKERKL LEERISDLTT NLAEEEEKAK NLTKLKNKHE SMISELEVRL
1060 1070 1080 1090 1100
KKEEKSRQEL EKLKRKLEGD ASDFHEQIAD LQAQIAELKM QLAKKEEELQ
1110 1120 1130 1140 1150
AALARLDDEI AQKNNALKKI RELEGHISDL QEDLDSERAA RNKAEKQKRD
1160 1170 1180 1190 1200
LGEELEALKT ELEDTLDSTA TQQELRAKRE QEVTVLKKAL DEETRSHEAQ
1210 1220 1230 1240 1250
VQEMRQKHAQ AVEELTEQLE QFKRAKANLD KNKQTLEKEN ADLAGELRVL
1260 1270 1280 1290 1300
GQAKQEVEHK KKKLEAQVQE LQSKCSDGER ARAELNDKVH KLQNEVESVT
1310 1320 1330 1340 1350
GMLNEAEGKA IKLAKDVASL SSQLQDTQEL LQEETRQKLN VSTKLRQLEE
1360 1370 1380 1390 1400
ERNSLQDQLD EEMEAKQNLE RHISTLNIQL SDSKKKLQDF ASTVEALEEG
1410 1420 1430 1440 1450
KKRFQKEIEN LTQQYEEKAA AYDKLEKTKN RLQQELDDLV VDLDNQRQLV
1460 1470 1480 1490 1500
SNLEKKQRKF DQLLAEEKNI SSKYADERDR AEAEAREKET KALSLARALE
1510 1520 1530 1540 1550
EALEAKEELE RTNKMLKAEM EDLVSSKDDV GKNVHELEKS KRALETQMEE
1560 1570 1580 1590 1600
MKTQLEELED ELQATEDAKL RLEVNMQALK GQFERDLQAR DEQNEEKRRQ
1610 1620 1630 1640 1650
LQRQLHEYET ELEDERKQRA LAAAAKKKLE GDLKDLELQA DSAIKGREEA
1660 1670 1680 1690 1700
IKQLRKLQAQ MKDFQRELED ARASRDEIFA TAKENEKKAK SLEADLMQLQ
1710 1720 1730 1740 1750
EDLAAAERAR KQADLEKEEL AEELASSLSG RNALQDEKRR LEARIAQLEE
1760 1770 1780 1790 1800
ELEEEQGNME AMSDRVRKAT QQAEQLSNEL ATERSTAQKN ESARQQLERQ
1810 1820 1830 1840 1850
NKELRSKLHE MEGAVKSKFK STIAALEAKI AQLEEQVEQE AREKQAATKS
1860 1870 1880 1890 1900
LKQKDKKLKE ILLQVEDERK MAEQYKEQAE KGNARVKQLK RQLEEAEEES
1910 1920 1930 1940 1950
QRINANRRKL QRELDEATES NEAMGREVNA LKSKLRGPPH RKLRSDAPGE
1960 1970 1980 1990 2000
ETRPLSFLLE GLEDVELLKM QMVLRRKRTL ETQTSMEPRP VNKQLSTVLH
2010 2020
HGKKTKNQNK QTKKTQQQPR TKQNPADCT
Length:2,029
Mass (Da):234,237
Last modified:April 29, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D3A556E7A244DB3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU489063 mRNA Translation: ACB05996.1

Genome annotation databases

UCSC genome browser

More...
UCSCi
uc059rfj.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU489063 mRNA Translation: ACB05996.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

MetOSiteiB1PS43
SwissPalmiB1PS43

Proteomic databases

EPDiB1PS43
MaxQBiB1PS43
PeptideAtlasiB1PS43
PRIDEiB1PS43
ProteomicsDBi3398

Genome annotation databases

UCSCiuc059rfj.1, human

Phylogenomic databases

PhylomeDBiB1PS43

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MYH11, human

Gene expression databases

BgeeiENSG00000133392, Expressed in saphenous vein and 249 other tissues

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR002928, Myosin_tail
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00063, Myosin_head, 1 hit
PF02736, Myosin_N, 1 hit
PF01576, Myosin_tail_1, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00015, IQ, 1 hit
SM00242, MYSc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB1PS43_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1PS43
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 29, 2021
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again