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Protein

Gap junction protein

Gene

Gja8

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.UniRule annotationSAAS annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction proteinUniRule annotation
Gene namesi
Name:Gja8Imported
ORF Names:rCG_52014Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalSequence analysisAdd BLAST22
Transmembranei78 – 97HelicalSequence analysisAdd BLAST20
Transmembranei158 – 179HelicalSequence analysisAdd BLAST22
Transmembranei211 – 229HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Gap junctionUniRule annotationSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000046703
ExpressionAtlasiB1PL12 differential

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.UniRule annotationSAAS annotation

Structurei

3D structure databases

SMRiB1PL12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 76CNXInterPro annotationAdd BLAST34
Domaini168 – 234Connexin_CCCInterPro annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili386 – 406Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the connexin family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IF3Z Eukaryota
ENOG410ZC96 LUCA
HOVERGENiHBG009576
OMAiLRTYICH
OrthoDBiEOG091G0FKH

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002266 Connexin50
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF19 PTHR11984:SF19, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PF03509 Connexin50, 1 hit
PRINTSiPR00206 CONNEXIN
PR01137 CONNEXINA8
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

B1PL12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS
60 70 80 90 100
DFVCNTQQPG CENVCYDEAF PISHIRLWVL QIIFVSTPSL MYVGHAVHHV
110 120 130 140 150
RMEEKRKDRE AEELCQQSRS NGGERVPIAP DQASIRKSSS SSKGTKKFRL
160 170 180 190 200
EGTLLRTYVC HIIFKTLFEV GFIVGHYFLY GFRILPLYRC SRWPCPNVVD
210 220 230 240 250
CFVSRPTEKT IFILFMLSVA FVSLFLNIME MSHLGMKGIR SAFKRPAEQP
260 270 280 290 300
LGEIAEKSLH SIAVSSIQKA KGYQLLEEEK IVSHYFPLTE VGMVETSPLS
310 320 330 340 350
AKPFSQFEEK IGTGPLADMS RGYQETLPSY AQVGAQEVER EEQPVEEAVE
360 370 380 390 400
PEVGEKKQEA EKVAPEGQET VAVPDGEKVE TPGVGKDDEK EELQAEKVTK
410 420 430 440
QGLSAEKAPT LCPELTTDDN RPLSRLSKAS SRARSDDLTI
Length:440
Mass (Da):49,401
Last modified:April 29, 2008 - v1
Checksum:iDDF57B9D6E1016AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU445790 Genomic DNA Translation: ACA49113.1
CH474015 Genomic DNA Translation: EDL85597.1
UniGeneiRn.86658

Similar proteinsi

Entry informationi

Entry nameiB1PL12_RAT
AccessioniPrimary (citable) accession number: B1PL12
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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