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Protein
Submitted name:

MHC class I antigen

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:HLA-AImported
Synonyms:HLAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000206503.11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35055

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501508707925 – 365Sequence analysisAdd BLAST341

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000206503 Expressed in 239 organ(s), highest expression level in mononuclear cell

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-likeInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
HOVERGENiHBG016709

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

B1PKY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,841
Last modified:April 29, 2008 - v1
Checksum:iDEDFCEC4450E0580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU445472 Genomic DNA Translation: ACA34992.1
GU812296 Genomic DNA Translation: ADE80887.1
KT156722 Genomic DNA Translation: ALO24306.1
KT266701 Genomic DNA Translation: ALP46208.1
KT266702 Genomic DNA Translation: ALP46209.1
KU528595 Genomic DNA Translation: ALZ40810.1
KT819308 Genomic DNA Translation: AMO26194.1
KX962567 Genomic DNA Translation: APO40931.1
KY072923 Genomic DNA Translation: AQN67170.1
KX583634 Genomic DNA Translation: ARX77874.1
KX686515 Genomic DNA Translation: ARX98023.1
KY235394 Genomic DNA Translation: ASA47542.1
KY368782 Genomic DNA Translation: ASA47563.1
KY368783 Genomic DNA Translation: ASA47564.1
KY419437 Genomic DNA Translation: ASU50328.1
KY419438 Genomic DNA Translation: ASU50329.1
MF474221 Genomic DNA Translation: ASU61671.1
MF474222 Genomic DNA Translation: ASU61672.1
MG199209 Genomic DNA Translation: AUF72633.1
MG372846 Genomic DNA Translation: AUL81601.1
KY613918 Genomic DNA Translation: AUP42581.1
KY613919 Genomic DNA Translation: AUP42582.1
MG450938 Genomic DNA Translation: AUQ33047.1
MF069202 Genomic DNA Translation: AWB14528.1
MH179252 Genomic DNA Translation: AWK57490.1
MH179254 Genomic DNA Translation: AWK57492.1
AB774956 Genomic DNA Translation: BAN59802.1
AB774974 Genomic DNA Translation: BAN59820.1
LC326117 Genomic DNA Translation: BBD74353.1
HG327114 mRNA Translation: CDG23669.1
HG794390 Genomic DNA Translation: CDK41199.1
HG794396 Genomic DNA Translation: CDK41205.1
LN877322 Genomic DNA Translation: CUA55065.1
LN994612 Genomic DNA Translation: CUV66664.1
LN994664 Genomic DNA Translation: CUV66716.1
LN994669 Genomic DNA Translation: CUV66721.1
LN994733 Genomic DNA Translation: CUV66785.1
LN999578 Genomic DNA Translation: CUX90971.1
LN999594 Genomic DNA Translation: CUX90987.1
LT219465 Genomic DNA Translation: CZQ50133.1
LT546644 Genomic DNA Translation: SAI65262.1
LT599184 Genomic DNA Translation: SBW38405.1
LT827023 Genomic DNA Translation: SLM20096.1
LT898182 Genomic DNA Translation: SNQ25992.1
LT971252 Genomic DNA Translation: SOX29892.1
LT971267 Genomic DNA Translation: SOX29908.1
LT971299 Genomic DNA Translation: SOX29941.1
LT972134 Genomic DNA Translation: SOX30050.1
LT972164 Genomic DNA Translation: SOX30080.1
LT986519 Genomic DNA Translation: SPF82192.1
LS398158 Genomic DNA Translation: SPQ44287.1
RefSeqiNP_002107.3, NM_002116.7
UniGeneiHs.181244
Hs.713441

Genome annotation databases

GeneIDi3105

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU445472 Genomic DNA Translation: ACA34992.1
GU812296 Genomic DNA Translation: ADE80887.1
KT156722 Genomic DNA Translation: ALO24306.1
KT266701 Genomic DNA Translation: ALP46208.1
KT266702 Genomic DNA Translation: ALP46209.1
KU528595 Genomic DNA Translation: ALZ40810.1
KT819308 Genomic DNA Translation: AMO26194.1
KX962567 Genomic DNA Translation: APO40931.1
KY072923 Genomic DNA Translation: AQN67170.1
KX583634 Genomic DNA Translation: ARX77874.1
KX686515 Genomic DNA Translation: ARX98023.1
KY235394 Genomic DNA Translation: ASA47542.1
KY368782 Genomic DNA Translation: ASA47563.1
KY368783 Genomic DNA Translation: ASA47564.1
KY419437 Genomic DNA Translation: ASU50328.1
KY419438 Genomic DNA Translation: ASU50329.1
MF474221 Genomic DNA Translation: ASU61671.1
MF474222 Genomic DNA Translation: ASU61672.1
MG199209 Genomic DNA Translation: AUF72633.1
MG372846 Genomic DNA Translation: AUL81601.1
KY613918 Genomic DNA Translation: AUP42581.1
KY613919 Genomic DNA Translation: AUP42582.1
MG450938 Genomic DNA Translation: AUQ33047.1
MF069202 Genomic DNA Translation: AWB14528.1
MH179252 Genomic DNA Translation: AWK57490.1
MH179254 Genomic DNA Translation: AWK57492.1
AB774956 Genomic DNA Translation: BAN59802.1
AB774974 Genomic DNA Translation: BAN59820.1
LC326117 Genomic DNA Translation: BBD74353.1
HG327114 mRNA Translation: CDG23669.1
HG794390 Genomic DNA Translation: CDK41199.1
HG794396 Genomic DNA Translation: CDK41205.1
LN877322 Genomic DNA Translation: CUA55065.1
LN994612 Genomic DNA Translation: CUV66664.1
LN994664 Genomic DNA Translation: CUV66716.1
LN994669 Genomic DNA Translation: CUV66721.1
LN994733 Genomic DNA Translation: CUV66785.1
LN999578 Genomic DNA Translation: CUX90971.1
LN999594 Genomic DNA Translation: CUX90987.1
LT219465 Genomic DNA Translation: CZQ50133.1
LT546644 Genomic DNA Translation: SAI65262.1
LT599184 Genomic DNA Translation: SBW38405.1
LT827023 Genomic DNA Translation: SLM20096.1
LT898182 Genomic DNA Translation: SNQ25992.1
LT971252 Genomic DNA Translation: SOX29892.1
LT971267 Genomic DNA Translation: SOX29908.1
LT971299 Genomic DNA Translation: SOX29941.1
LT972134 Genomic DNA Translation: SOX30050.1
LT972164 Genomic DNA Translation: SOX30080.1
LT986519 Genomic DNA Translation: SPF82192.1
LS398158 Genomic DNA Translation: SPQ44287.1
RefSeqiNP_002107.3, NM_002116.7
UniGeneiHs.181244
Hs.713441

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi3105
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3105

Organism-specific databases

CTDi3105
EuPathDBiHostDB:ENSG00000206503.11
PharmGKBiPA35055

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
HOVERGENiHBG016709

Miscellaneous databases

ChiTaRSiHLA-A human
GenomeRNAii3105

Gene expression databases

BgeeiENSG00000206503 Expressed in 239 organ(s), highest expression level in mononuclear cell

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1PKY1_HUMAN
AccessioniPrimary (citable) accession number: B1PKY1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: October 10, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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