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Protein
Submitted name:

MHC class I antigen

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MHC class I antigenImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-AImported
Synonyms:HLAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000206503.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei308 – 332HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35055

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501508707925 – 365Sequence analysisAdd BLAST341

Keywords - PTMi

Disulfide bondSAAS annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000206503 Expressed in 239 organ(s), highest expression level in mononuclear cell

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini209 – 295Ig-likeInterPro annotationAdd BLAST87

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II5V Eukaryota
ENOG4111K8F LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG016709

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.30.500.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01638 MHCCLASSI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407 IGc1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B1PKY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,841
Last modified:April 29, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDEDFCEC4450E0580
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU445472 Genomic DNA Translation: ACA34992.1
GU812296 Genomic DNA Translation: ADE80887.1
KT156722 Genomic DNA Translation: ALO24306.1
KT266701 Genomic DNA Translation: ALP46208.1
KT266702 Genomic DNA Translation: ALP46209.1
KU528595 Genomic DNA Translation: ALZ40810.1
KT819308 Genomic DNA Translation: AMO26194.1
KX962567 Genomic DNA Translation: APO40931.1
KY072923 Genomic DNA Translation: AQN67170.1
KX583634 Genomic DNA Translation: ARX77874.1
KX686515 Genomic DNA Translation: ARX98023.1
KY235394 Genomic DNA Translation: ASA47542.1
KY368782 Genomic DNA Translation: ASA47563.1
KY368783 Genomic DNA Translation: ASA47564.1
KY419437 Genomic DNA Translation: ASU50328.1
KY419438 Genomic DNA Translation: ASU50329.1
MF474221 Genomic DNA Translation: ASU61671.1
MF474222 Genomic DNA Translation: ASU61672.1
MG199209 Genomic DNA Translation: AUF72633.1
MG372846 Genomic DNA Translation: AUL81601.1
KY613918 Genomic DNA Translation: AUP42581.1
KY613919 Genomic DNA Translation: AUP42582.1
MG450938 Genomic DNA Translation: AUQ33047.1
MF069202 Genomic DNA Translation: AWB14528.1
MH179252 Genomic DNA Translation: AWK57490.1
MH179254 Genomic DNA Translation: AWK57492.1
MH630135 Genomic DNA Translation: AXO67719.1
AB774956 Genomic DNA Translation: BAN59802.1
AB774974 Genomic DNA Translation: BAN59820.1
LC326117 Genomic DNA Translation: BBD74353.1
HG327114 mRNA Translation: CDG23669.1
HG794390 Genomic DNA Translation: CDK41199.1
HG794396 Genomic DNA Translation: CDK41205.1
LN877322 Genomic DNA Translation: CUA55065.1
LN994612 Genomic DNA Translation: CUV66664.1
LN994664 Genomic DNA Translation: CUV66716.1
LN994669 Genomic DNA Translation: CUV66721.1
LN994733 Genomic DNA Translation: CUV66785.1
LN999578 Genomic DNA Translation: CUX90971.1
LN999594 Genomic DNA Translation: CUX90987.1
LT219465 Genomic DNA Translation: CZQ50133.1
LT546644 Genomic DNA Translation: SAI65262.1
LT599184 Genomic DNA Translation: SBW38405.1
LT827023 Genomic DNA Translation: SLM20096.1
LT898182 Genomic DNA Translation: SNQ25992.1
LT963213 Genomic DNA Translation: SOR74757.1
LT963223 Genomic DNA Translation: SOR74767.1
LT963255 Genomic DNA Translation: SOR74799.1
LT963289 Genomic DNA Translation: SOR74833.1
LT986519 Genomic DNA Translation: SPF82192.1
LS398158 Genomic DNA Translation: SPQ44287.1

NCBI Reference Sequences

More...
RefSeqi
NP_002107.3, NM_002116.7

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.181244
Hs.713441

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3105

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU445472 Genomic DNA Translation: ACA34992.1
GU812296 Genomic DNA Translation: ADE80887.1
KT156722 Genomic DNA Translation: ALO24306.1
KT266701 Genomic DNA Translation: ALP46208.1
KT266702 Genomic DNA Translation: ALP46209.1
KU528595 Genomic DNA Translation: ALZ40810.1
KT819308 Genomic DNA Translation: AMO26194.1
KX962567 Genomic DNA Translation: APO40931.1
KY072923 Genomic DNA Translation: AQN67170.1
KX583634 Genomic DNA Translation: ARX77874.1
KX686515 Genomic DNA Translation: ARX98023.1
KY235394 Genomic DNA Translation: ASA47542.1
KY368782 Genomic DNA Translation: ASA47563.1
KY368783 Genomic DNA Translation: ASA47564.1
KY419437 Genomic DNA Translation: ASU50328.1
KY419438 Genomic DNA Translation: ASU50329.1
MF474221 Genomic DNA Translation: ASU61671.1
MF474222 Genomic DNA Translation: ASU61672.1
MG199209 Genomic DNA Translation: AUF72633.1
MG372846 Genomic DNA Translation: AUL81601.1
KY613918 Genomic DNA Translation: AUP42581.1
KY613919 Genomic DNA Translation: AUP42582.1
MG450938 Genomic DNA Translation: AUQ33047.1
MF069202 Genomic DNA Translation: AWB14528.1
MH179252 Genomic DNA Translation: AWK57490.1
MH179254 Genomic DNA Translation: AWK57492.1
MH630135 Genomic DNA Translation: AXO67719.1
AB774956 Genomic DNA Translation: BAN59802.1
AB774974 Genomic DNA Translation: BAN59820.1
LC326117 Genomic DNA Translation: BBD74353.1
HG327114 mRNA Translation: CDG23669.1
HG794390 Genomic DNA Translation: CDK41199.1
HG794396 Genomic DNA Translation: CDK41205.1
LN877322 Genomic DNA Translation: CUA55065.1
LN994612 Genomic DNA Translation: CUV66664.1
LN994664 Genomic DNA Translation: CUV66716.1
LN994669 Genomic DNA Translation: CUV66721.1
LN994733 Genomic DNA Translation: CUV66785.1
LN999578 Genomic DNA Translation: CUX90971.1
LN999594 Genomic DNA Translation: CUX90987.1
LT219465 Genomic DNA Translation: CZQ50133.1
LT546644 Genomic DNA Translation: SAI65262.1
LT599184 Genomic DNA Translation: SBW38405.1
LT827023 Genomic DNA Translation: SLM20096.1
LT898182 Genomic DNA Translation: SNQ25992.1
LT963213 Genomic DNA Translation: SOR74757.1
LT963223 Genomic DNA Translation: SOR74767.1
LT963255 Genomic DNA Translation: SOR74799.1
LT963289 Genomic DNA Translation: SOR74833.1
LT986519 Genomic DNA Translation: SPF82192.1
LS398158 Genomic DNA Translation: SPQ44287.1
RefSeqiNP_002107.3, NM_002116.7
UniGeneiHs.181244
Hs.713441

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3105
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3105

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3105
EuPathDBiHostDB:ENSG00000206503.11
PharmGKBiPA35055

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
HOVERGENiHBG016709

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HLA-A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3105

Gene expression databases

BgeeiENSG00000206503 Expressed in 239 organ(s), highest expression level in mononuclear cell

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB1PKY1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1PKY1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 5, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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