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Entry version 34 (16 Jan 2019)
Sequence version 2 (05 Oct 2010)
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Protein

N.vectensis toxin 1 3

Gene

v1g113139

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process. Is highly active on DmNav1/TipE (drosophila) and is only extremely weakly active on rat Nav1.4-beta-1/SCN4A-SCN1B, and on human Nav1.5-beta-1/SCN5A-beta-1. Has no activity on the rat brain channel Nav1.2a-beta-1/SCN2A-SCN1B. This reveals high specificity for insect over mammalian channels.1 Publication

Miscellaneous

Nv1 toxin seems to be encoded by 8 different genes. 4 of them code for identical precursors, whereas 4 others code for very similar precursors. In the genome draft, 6 additional loci are also correlated to Nv1 toxin, but they are not predicted to be functional genes. This high similarity may be explained by concerted evolution.
The primary structure of the mature peptide is identical in 9 entries (AC B1NWS4, AC B1NWS1, AC B1NWR6, AC P0CH90, AC P0CH46, AC B1NWS8, AC A7SCE5, AC B1NWR7 and AC P0CH45). Additional information can be found in entry AC B1NWS4.Curated

Caution

The 8 variants shown here could also be shown in the 3 identical proteins (AC B1NWS4, AC P0CH46 and AC B1NWR7) encoded by the 3 different genes.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N.vectensis toxin 1 31 Publication
Short name:
Nv11 Publication
Alternative name(s):
Delta-edwarditoxin-Nvc1c1 Publication
Short name:
Delta-EWTX-Nvc1c1 Publication
Delta-edwarditoxin-Nvc1d1 Publication
Short name:
Delta-EWTX-Nvc1d1 Publication
Neurotoxin Nv1-116.28.11 Publication
Neurotoxin Nv1-13Imported
Neurotoxin Nv1-15Imported
Neurotoxin Nv1-17CuratedImported
Neurotoxin Nv1-18CuratedImported
Neurotoxin Nv1-19CuratedImported
Neurotoxin Nv1-2Imported
Neurotoxin Nv1-4Imported
Neurotoxin Nv1-5Imported
Neurotoxin Nv1-8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:v1g113139
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNematostella vectensis (Starlet sea anemone)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri45351 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001593 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nematocyst, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the lethal dose (LD), paralytic dose (PD), effect dose (ED) or lethal concentration (LC) of a protein toxin.<p><a href='/help/toxic_dose' target='_top'>More...</a></p>Toxic dosei

PD50 is 76 nmol/kg into blowfly larvae.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000039831121 – 36CuratedAdd BLAST16
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500031966039 – 85N.vectensis toxin 1 31 PublicationAdd BLAST47

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 82By similarity
Disulfide bondi44 ↔ 72By similarity
Disulfide bondi65 ↔ 83By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Nv1 is transcribed throughout the complete life cycle. Transcripts of Nv1 are not spliced in the embryo and planula (intron retention). It is unknown whether the unspliced transcript has a function as it contains a premature stop codon.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B1NWR6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B1NWR6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000693 Anenome_toxin
IPR023355 Myo_ane_neurotoxin_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00706 Toxin_4, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001905 Anenome_toxin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Intron retention discovered for all transcripts, no experimental confirmation available for this specific sequence.
Isoform 1 (identifier: B1NWR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASFKIVIVC LALLVAVACA RRRDMMSDDE LDFHLSKRGI PCACDSDGPD
60 70 80
IRSASLSGIV WMGSCPSGWK KCKSYYSIVA DCCNQ
Length:85
Mass (Da):9,268
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26673B8F76FA1099
GO
Isoform 2 (identifier: B1NWR6-2) [UniParc]FASTAAdd to basket
Also known as: truncated

The sequence of this isoform differs from the canonical sequence as follows:
     23-85: RDMMSDDELDFHLSKRGIPCACDSDGPDIRSASLSGIVWMGSCPSGWKKCKSYYSIVADCCNQ → K

Note: Due to an intron retention observed only in early life stages (embryo and planula).
Show »
Length:23
Mass (Da):2,476
Checksum:iAACDB0C9FBC2E6D8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EDO38670 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti3S → L in Nv1-15. 1
Natural varianti5K → N in Nv1-17 and in Nv1-18. 1
Natural varianti9V → A in Nv1-5, Nv8/Nv19 and Nv1-15. 1
Natural varianti13L → V in Nv1-15. 1
Natural varianti19C → S in Nv1-2, Nv1-13. 1
Natural varianti29D → T in Nv1-13. 1
Natural varianti33F → Y in Nv1-4, Nv8/Nv19. 1
Natural varianti43A → V in Nv1-18. 1
Natural varianti62M → V in Nv1-4. 1
Natural varianti78I → V in Nv1-13. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03974523 – 85RDMMS…DCCNQ → K in isoform 2. CuratedAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU422969 mRNA Translation: ACB71118.1
EU422970 mRNA Translation: ACB71119.1
EU422971 mRNA Translation: ACB71120.1
EU124453 Genomic DNA Translation: ABW97332.1
EU124455 Genomic DNA Translation: ABW97334.1
EU124456 Genomic DNA Translation: ABW97335.1
EU124459 Genomic DNA Translation: ABW97338.1
EU124464 Genomic DNA Translation: ABW97343.1
EU124466 Genomic DNA Translation: ABW97345.1
DS469622 Genomic DNA Translation: EDO38670.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
XP_001630733.1, XM_001630683.1
XP_001630735.1, XM_001630685.1
XP_001630737.1, XM_001630687.1
XP_001630739.1, XM_001630689.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Nve.10491

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5510238
5510239
5510240
5510260

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nve:NEMVE_v1g113108
nve:NEMVE_v1g113139
nve:NEMVE_v1g113166
nve:NEMVE_v1g113209

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU422969 mRNA Translation: ACB71118.1
EU422970 mRNA Translation: ACB71119.1
EU422971 mRNA Translation: ACB71120.1
EU124453 Genomic DNA Translation: ABW97332.1
EU124455 Genomic DNA Translation: ABW97334.1
EU124456 Genomic DNA Translation: ABW97335.1
EU124459 Genomic DNA Translation: ABW97338.1
EU124464 Genomic DNA Translation: ABW97343.1
EU124466 Genomic DNA Translation: ABW97345.1
DS469622 Genomic DNA Translation: EDO38670.1 Sequence problems.
RefSeqiXP_001630733.1, XM_001630683.1
XP_001630735.1, XM_001630685.1
XP_001630737.1, XM_001630687.1
XP_001630739.1, XM_001630689.1
UniGeneiNve.10491

3D structure databases

ProteinModelPortaliB1NWR6
SMRiB1NWR6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5510238
5510239
5510240
5510260
KEGGinve:NEMVE_v1g113108
nve:NEMVE_v1g113139
nve:NEMVE_v1g113166
nve:NEMVE_v1g113209

Family and domain databases

Gene3Di2.20.20.10, 1 hit
InterProiView protein in InterPro
IPR000693 Anenome_toxin
IPR023355 Myo_ane_neurotoxin_sf
PfamiView protein in Pfam
PF00706 Toxin_4, 1 hit
PIRSFiPIRSF001905 Anenome_toxin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNA228_NEMVE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1NWR6
Secondary accession number(s): A7SCE0
, B1NWR8, B1NWR9, B1NWS2, B1NWS7, B1NWS9, B5L633, B5L634
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: January 16, 2019
This is version 34 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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