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Protein

Alanine racemase

Gene

alr2

Organism
Leuconostoc citreum (strain KM20)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr2), Alanine racemase (alr1)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei142SubstrateUniRule annotation1
Active sitei271Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei318Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr2Imported
Ordered Locus Names:LCK_00225Imported
OrganismiLeuconostoc citreum (strain KM20)Imported
Taxonomic identifieri349519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
Proteomesi
  • UP000002166 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi349519.LCK_00225

Structurei

3D structure databases

ProteinModelPortaliB1MX06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 375Ala_racemase_CInterPro annotationAdd BLAST126

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiYSDGYRR

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

B1MX06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQKDTLLT RPSWIEIDLG AIQENAQSIM AHAGAKRLIA VVKADGYGHG
60 70 80 90 100
ATPVANALYE IGVRDFAVAT IGEGIKLRQE LAYQDYRIVL LGVQDIAHVD
110 120 130 140 150
VMVKYRLSPA IESIDWLSVA LQAIPEGATL DVELAVDTGM GRMGAHSKEA
160 170 180 190 200
VYSVYRYIKN NDKLELGGVF THFATADDSN IGYYKQQAQR FNDWVTAAGI
210 220 230 240 250
PRQYWHLANS GSALWHTQEI DTRTIRVGSV LYGYNPGAPL LTLPIPLKHV
260 270 280 290 300
FALKSRIGAV HQLITGESVS YGATYTAQKP QWVATLPIGY ADGYLRRMAG
310 320 330 340 350
MRVLINGKVT YVIGRITMDQ IVIALDQAYP IGTEVTLIGR DGDNEITVEE
360 370
FADYANTIPH EILTSFGPRL PRIYKK
Length:376
Mass (Da):41,480
Last modified:April 29, 2008 - v1
Checksum:iA170DBEE6E69B81F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ489736 Genomic DNA Translation: ACA82058.1
RefSeqiWP_004907548.1, NC_010471.1

Genome annotation databases

EnsemblBacteriaiACA82058; ACA82058; LCK_00225
GeneIDi35825153
KEGGilci:LCK_00225

Similar proteinsi

Entry informationi

Entry nameiB1MX06_LEUCK
AccessioniPrimary (citable) accession number: B1MX06
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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