PI4KB

Functionⁱ

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity).By similarity

Catalytic activityⁱ

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.

Enzyme regulationⁱ

Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ.By similarity

GO - Molecular functionⁱ

14-3-3 protein binding Source: UniProtKB
1-phosphatidylinositol 4-kinase activity Source: UniProtKB-EC
ATP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

phosphatidylinositol-mediated signaling Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphatidylinositol 4-kinase beta (EC:2.7.1.67) Short name: PI4K-beta Short name: PI4Kbeta Short name: PtdIns 4-kinase beta
Gene namesⁱ	Name:PI4KB Synonyms:PIK4CB
Organismⁱ	Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch)
Taxonomic identifierⁱ	9523 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Platyrrhini › Pitheciidae › Callicebinae › Plecturocebus

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000365164	2 – 816	Phosphatidylinositol 4-kinase betaAdd BLAST		815

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylglycineBy similarity	1
Modified residueⁱ	258	PhosphoserineBy similarity	1
Modified residueⁱ	263	PhosphothreonineBy similarity	1
Modified residueⁱ	266	PhosphoserineBy similarity	1
Modified residueⁱ	275	PhosphoserineBy similarity	1
Modified residueⁱ	277	PhosphoserineBy similarity	1
Modified residueⁱ	284	PhosphoserineBy similarity	1
Modified residueⁱ	294	PhosphoserineBy similarity	1
Modified residueⁱ	428	PhosphoserineBy similarity	1
Modified residueⁱ	438	PhosphothreonineBy similarity	1
Modified residueⁱ	511	PhosphoserineBy similarity	1
Modified residueⁱ	517	PhosphothreonineBy similarity	1
Modified residueⁱ	519	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Interactionⁱ

Subunit structureⁱ

Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (By similarity). Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity). Interacts with ACBD3. Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (By similarity).By similarity

GO - Molecular functionⁱ

14-3-3 protein binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B1MTG7
SMRⁱ	B1MTG7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	52 – 242	PIK helicalPROSITE-ProRule annotationAdd BLAST		191
Domainⁱ	559 – 765	PI3K/PI4KPROSITE-ProRule annotationAdd BLAST		207

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 68	Interaction with ACBD3By similarityAdd BLAST		67

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	117 – 120	Poly-Arg		4

Sequence similaritiesⁱ

Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.Curated

Phylogenomic databases

HOVERGENⁱ	HBG053597

HOVERGENⁱ

HBG053597

Family and domain databases

Gene3Dⁱ	1.10.1070.11, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000403 PI3/4_kinase_cat_dom IPR036940 PI3/4_kinase_cat_sf IPR018936 PI3/4_kinase_CS IPR015433 PI_Kinase IPR001263 PInositide-3_kin_accessory_dom
PANTHERⁱ	PTHR10048 PTHR10048, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00454 PI3_PI4_kinase, 1 hit
SMARTⁱ	View protein in SMART SM00146 PI3Kc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS00915 PI3_4_KINASE_1, 1 hit PS00916 PI3_4_KINASE_2, 1 hit PS50290 PI3_4_KINASE_3, 1 hit PS51545 PIK_HELICAL, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

B1MTG7-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MGDTVVEPAP LKPTSEPTSG PPGNNGGSLL SVITEGVGEL SVIDPEVAQK 
        60         70         80         90        100
ACQDVLEKVK LLHGGMAVSS KGAPLELVNG DGVDSEIRCL DDPPAQIREE 
       110        120        130        140        150
EDEMGATVAS GTAKGARRRR QNNSAKQSWL LRLFESKLFD ISMAISYLYN 
       160        170        180        190        200
SKEPGVQAYI GNRLFCFRNE DVDFYLPQLL NMYIHMDEDV GDAIKPYIVY 
       210        220        230        240        250
RCRQSINFSL QCALLLGAYS SDMHISTQRH SRGTKLRKLI LSDELKPAHR 
       260        270        280        290        300
KRELPSLSPA PDTGLSPSKR THQRSKSDAT ASISLSSNLK RTASNPKVEN 
       310        320        330        340        350
EDEELSSSTE SIDNSFSSPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ 
       360        370        380        390        400
RLISELSLLN HKLPARVWLP TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY 
       410        420        430        440        450
VEVLECENFD TTSVPARIPE NRIRSTRSVE NLPECGITHE QRAGSFSTVP 
       460        470        480        490        500
NYDNDDEAWS VDDIGELQVE LPEVHTNSCD NISQFSVDSI TSQESKEPVF 
       510        520        530        540        550
IAAGDIRRRL SEQLAHTPTA FKRDPEDPSA VALKEPWQEK VRRIREGSPY 
       560        570        580        590        600
GHLPNWRLLS VIVKCGDDLR QELLAFQVLK QLQSIWEQER VPLWIKPYKI 
       610        620        630        640        650
LVISADSGMI EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS YTTEAFLSAQ 
       660        670        680        690        700
RNFVQSCAGY CLVCYLLQVK DRHNGNILLD AEGHIIHIDF GFILSSSPRN 
       710        720        730        740        750
LGFETSAFKL TTEFVDVMGG LDGDMFNYYK MLMLQGLIAA RKHMDKVVQI 
       760        770        780        790        800
VEIMQQGSQL PCFHGSSTIR NLKERFHMSM TEEQLQLLVE QMVDGSMRSI 
       810 
TTKLYDGFQY LTNGIM

Length:816

Mass (Da):91,395

Last modified:April 29, 2008 - v1

Checksum:ⁱ0EF3788F9300D08D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DP000634 Genomic DNA Translation: ACA57933.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

DP000634 Genomic DNA Translation: ACA57933.1

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
B1MTG7	Phosphatidylinositol 4-kinase beta	)	HUMAN		816
UPI000C9EE000		OCTDE		880
UPI0004DFE5ED		URSMA		854
UPI0004E51338		PAPAN		849
UPI0005332AF0		RHIRO		849
+375

Protein	Similar proteins		Species	Score	Length
B1MTG7	Phosphatidylinositol 4-kinase beta	)	HUMAN		816
UPI000C9EE000		OCTDE		880
UPI0004DFE5ED		URSMA		854
UPI00083C6FFA		RHIBE		849
UPI0007DBEC40		PANTR		849
+614

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DP000634 Genomic DNA Translation: ACA57933.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

DP000634 Genomic DNA Translation: ACA57933.1

3D structure databases

ProteinModelPortalⁱ	B1MTG7
SMRⁱ	B1MTG7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

HOVERGENⁱ	HBG053597

HOVERGENⁱ

HBG053597

Family and domain databases

Gene3Dⁱ	1.10.1070.11, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000403 PI3/4_kinase_cat_dom IPR036940 PI3/4_kinase_cat_sf IPR018936 PI3/4_kinase_CS IPR015433 PI_Kinase IPR001263 PInositide-3_kin_accessory_dom
PANTHERⁱ	PTHR10048 PTHR10048, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00454 PI3_PI4_kinase, 1 hit
SMARTⁱ	View protein in SMART SM00146 PI3Kc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS00915 PI3_4_KINASE_1, 1 hit PS00916 PI3_4_KINASE_2, 1 hit PS50290 PI3_4_KINASE_3, 1 hit PS51545 PIK_HELICAL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PI4KB_PLEMO
Accessionⁱ	B1MTG7Primary (citable) accession number: B1MTG7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
	Last sequence update:	April 29, 2008
	Last modified:	June 20, 2018
	This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Documents

SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B1MTG7 (PI4KB_PLEMO)

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Phosphatidylinositol 4-kinase beta

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Golgi apparatus

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Golgi apparatus

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

Enzyme regulationⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ