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Protein

Neuraminidase

Gene

NA

Organism
Influenza A virus (A/duck/Shantou/4407/2001(H5N1))
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.UniRule annotationSAAS annotation

Cofactori

Ca2+UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseUniRule annotationSAAS annotation, Hydrolase
LigandCalciumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Protein family/group databases

CAZyiGH34 Glycoside Hydrolase Family 34

Names & Taxonomyi

Protein namesi
Recommended name:
NeuraminidaseUniRule annotationSAAS annotation (EC:3.2.1.18UniRule annotationSAAS annotation)
Gene namesi
Name:NAUniRule annotationImported
OrganismiInfluenza A virus (A/duck/Shantou/4407/2001(H5N1))Imported
Taxonomic identifieri496768 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeAlphainfluenzavirus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 34HelicalSequence analysisAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host membrane, Membrane, VirionUniRule annotationSAAS annotation

PTM / Processingi

Post-translational modificationi

N-glycosylated.UniRule annotation

Keywords - PTMi

Disulfide bondSAAS annotation, GlycoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 34 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

HAMAPiMF_04071 INFV_NRAM, 1 hit
InterProiView protein in InterPro
IPR001860 Glyco_hydro_34
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00064 Neur, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Fragment.

B1MPX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPNRKIITI GSICMVIGIV SLMLQIGNII SIWVSHSIQT ENQHQAEPIS
60 70 80 90 100
NTNFLTEKAV ASVTLAGNSS LCPISGWAIH SKDNGIRIGS KGDVFVIREP
110 120 130 140 150
FISCSHLECR TFFLTQGALL NDKHSNGTVK DRSPHRTLMS CPVGEAPSPY
160 170 180 190 200
NSRFESVAWS ASACHDGTSW LTIGISGPDN GAVAVLKYNG IITDTIKSWR
210 220 230 240 250
NNILRTQESE CACVNGSCFT VMTDGPSNGQ ASYKIFKMEK GKVVKSVELD
260 270 280 290 300
APNYHYEECS CYPDAGEVTC VCRDNWHGSN RPWVSFNQNL EYQIGYICSG
310 320 330 340 350
VFGDNPRPND GTGSCGPMSL NGAYGVKGFS FKYGNGVWIG RTKSTNSRSG
360 370 380 390 400
FEMIWDPNGW TGTDSSFSVK QDIVAITDWS GYSGSFVQHP ELTGLDCIRP
410 420
CFWVELIRGR PKESTIWTSG SSISFCGVN
Length:429
Mass (Da):46,850
Last modified:April 29, 2008 - v1
Checksum:i75E77E721E2D77A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei429Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CY029050 Viral cRNA Translation: ACA47485.1

Similar proteinsi

Entry informationi

Entry nameiB1MPX3_9INFA
AccessioniPrimary (citable) accession number: B1MPX3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 25, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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