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Protein

ATP-dependent protease ATPase subunit HslU

Gene

hslU

Organism
Thermotoga sp. (strain RQ2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei276ATPUniRule annotation1
Binding sitei341ATPUniRule annotation1
Binding sitei413ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 68ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTSP126740:G1GBG-423-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent protease ATPase subunit HslUUniRule annotation
Alternative name(s):
Unfoldase HslUUniRule annotation
Gene namesi
Name:hslUUniRule annotation
Ordered Locus Names:TRQ2_0415
OrganismiThermotoga sp. (strain RQ2)
Taxonomic identifieri126740 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000001687 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001009791 – 463ATP-dependent protease ATPase subunit HslUAdd BLAST463

Interactioni

Subunit structurei

A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB1L8X3
SMRiB1L8X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ClpX chaperone family. HslU subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000010036
KOiK03667
OMAiKYGMIKT
OrthoDBiPOG091H01U4

Family and domain databases

HAMAPiMF_00249 HslU, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004491 HslU
IPR027417 P-loop_NTPase
PANTHERiPTHR43815 PTHR43815, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF07724 AAA_2, 1 hit
PF10431 ClpB_D2-small, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01086 ClpB_D2-small, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00390 hslU, 1 hit

Sequencei

Sequence statusi: Complete.

B1L8X3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSFDEMTPK EIVQELDKYI VGQYEAKKAV AIAVRNRIRR QKLPEEWRKE
60 70 80 90 100
VLPKNILMIG PTGVGKTEIA RRLAQLSGSP FLKVEATRFT EVGYVGKNVD
110 120 130 140 150
SMIRDLVEIS VNMVKQEKIK EVERQAEELV EERILDALVP ESKAVPVVTN
160 170 180 190 200
PFINLITGGQ QQQYTPEDRR RFRAKREEMR EKLRKGELEN EEIEIELEET
210 220 230 240 250
VSPFMGIFGP GMEDLGIEIT NMFSGMLPKQ KKKRKMKVSE ARKVLLPLEA
260 270 280 290 300
EKLIDMDKVV QEALDRAQNR GIIFIDEIDK IAGKESAVGP DVSRQGVQRD
310 320 330 340 350
LLPIVEGTTI MTKYGPVRTD YILFIAAGAF HVSRPSDLIP ELQGRFPIRV
360 370 380 390 400
ELSPLTEEDF VRILKEPENA IIKQYQALLS TEGVELVFTE DGIREMARIA
410 420 430 440 450
YQLNQRLENI GARRLYTVAE KVLEEISFEA PDIPEKRIVV DAEYVRRRLE
460
RIVQDEDLSA YIL
Length:463
Mass (Da):53,049
Last modified:April 29, 2008 - v1
Checksum:i1B7894B4EFD303EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000969 Genomic DNA Translation: ACB08771.1
RefSeqiWP_012310532.1, NC_010483.1

Genome annotation databases

EnsemblBacteriaiACB08771; ACB08771; TRQ2_0415
KEGGitrq:TRQ2_0415

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000969 Genomic DNA Translation: ACB08771.1
RefSeqiWP_012310532.1, NC_010483.1

3D structure databases

ProteinModelPortaliB1L8X3
SMRiB1L8X3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB08771; ACB08771; TRQ2_0415
KEGGitrq:TRQ2_0415

Phylogenomic databases

HOGENOMiHOG000010036
KOiK03667
OMAiKYGMIKT
OrthoDBiPOG091H01U4

Enzyme and pathway databases

BioCyciTSP126740:G1GBG-423-MONOMER

Family and domain databases

HAMAPiMF_00249 HslU, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004491 HslU
IPR027417 P-loop_NTPase
PANTHERiPTHR43815 PTHR43815, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF07724 AAA_2, 1 hit
PF10431 ClpB_D2-small, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01086 ClpB_D2-small, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00390 hslU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSLU_THESQ
AccessioniPrimary (citable) accession number: B1L8X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: October 10, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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