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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Thermotoga sp. (strain RQ2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:TRQ2_0362
OrganismiThermotoga sp. (strain RQ2)
Taxonomic identifieri126740 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000001687 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000948261 – 335S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST335

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB1L8S0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004402
KOiK07568
OMAiLSKHKMD
OrthoDBiPOG091H00ZG

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

B1L8S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSEFDYEL PSELIAQEPV EPRDASRLMV LHRKTQRIEH RIFREIIEYL
60 70 80 90 100
EPGDLLVLNV SKVIPARLYA RKKTGASIEI LLIERLEEGI WKCLVRPGQK
110 120 130 140 150
VKKGTELVID EDLSAVCLGR GEDGTRILKF QPQDDRLIFE KGRTPLPPYI
160 170 180 190 200
KNEVPLERYQ TVYAKEEGSV AAPTAGLHFT PELIEKLKKK GVQFAEVVLH
210 220 230 240 250
VGIGTFRPVK VEEVEKHKMH EEFYQVTKET IKKLRETRER GNRIVAVGTT
260 270 280 290 300
TVRTLETIAR LPEQEEYVGK TDLFIYPPFE FKLVDALITN FHLPRSTLLM
310 320 330
LVAAFAGKDF VMEAYREAVK RRYRFFSFGD AMLIL
Length:335
Mass (Da):38,656
Last modified:April 29, 2008 - v1
Checksum:iEC7BEC211FBD0E8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000969 Genomic DNA Translation: ACB08718.1
RefSeqiWP_011943008.1, NC_010483.1

Genome annotation databases

EnsemblBacteriaiACB08718; ACB08718; TRQ2_0362
GeneIDi29653300
KEGGitrq:TRQ2_0362

Similar proteinsi

Entry informationi

Entry nameiQUEA_THESQ
AccessioniPrimary (citable) accession number: B1L8S0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: December 20, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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