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Protein

Alanine racemase

Gene

alr

Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei144SubstrateUniRule annotation1
Active sitei275Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei328Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CLK_3463Imported
OrganismiClostridium botulinum (strain Loch Maree / Type A3)Imported
Taxonomic identifieri498214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000722 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliB1KTP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini254 – 387Ala_racemase_CInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000031444
KOiK01775
OMAiISHFACA
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

B1KTP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEHSRPAWI EINLDNLIHN MKEIRRVARS KEIISVVKAD AYGHGALEIA
60 70 80 90 100
SLLLENGANR LAVAVLSEAL ELRNNGITAP IIILGYTPLR YDEKTICNNA
110 120 130 140 150
ETIIKNDLEV SVSSYKYAEQ LSKKAQQLGK DVKIHVNIDT GMGRLGFLPT
160 170 180 190 200
EENLEKIYQI SKLPNIIFEG LFSHFSTADE KNKDYTNEQF KKFLDFYYKL
210 220 230 240 250
RDKNVKVNIK HIANSAALID LPYTHLDAVR PGIAQYGYYP SSEVNHKDIN
260 270 280 290 300
LRPIMTLKTN IVLVKDIKSG QSISYGRKFR TIRNSKIAVL PIGYADGYER
310 320 330 340 350
ELSNENNVYK AQVIVNGRRA PIVGRITMDM CMIDVTDIGD VKVGDEVILI
360 370 380 390 400
GECNDERISV EDIADLLNTI PYEVTSRISK RIPRYYMKDG KIVKISQINK

EVNK
Length:404
Mass (Da):45,827
Last modified:April 29, 2008 - v1
Checksum:i08F9BC365E395B72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000962 Genomic DNA Translation: ACA53599.1
RefSeqiWP_012341804.1, NC_010520.1

Genome annotation databases

EnsemblBacteriaiACA53599; ACA53599; CLK_3463
KEGGicbl:CLK_3463

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000962 Genomic DNA Translation: ACA53599.1
RefSeqiWP_012341804.1, NC_010520.1

3D structure databases

ProteinModelPortaliB1KTP9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA53599; ACA53599; CLK_3463
KEGGicbl:CLK_3463

Phylogenomic databases

HOGENOMiHOG000031444
KOiK01775
OMAiISHFACA
OrthoDBiPOG091H022F

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1KTP9_CLOBM
AccessioniPrimary (citable) accession number: B1KTP9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: October 10, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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