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Protein

Molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei23GTPUniRule annotation1
Binding sitei51GTPUniRule annotation1
Binding sitei69GTPUniRule annotation1
Metal bindingi99MagnesiumUniRule annotation1
Binding sitei99GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 12GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOO392500:G1GBD-99-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:Swoo_0084
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002168 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001158091 – 196Molybdenum cofactor guanylyltransferaseAdd BLAST196

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi392500.Swoo_0084.

Structurei

3D structure databases

ProteinModelPortaliB1KL44.
SMRiB1KL44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6R. Bacteria.
COG0746. LUCA.
HOGENOMiHOG000280423.
KOiK03752.
OMAiFVPCDVP.
OrthoDBiPOG091H05CW.

Family and domain databases

CDDicd02503. MobA. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_00316. MobA. 1 hit.
InterProiView protein in InterPro
IPR025877. MobA-like_NTP_Trfase.
IPR013482. Molybde_CF_guanTrfase.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF12804. NTP_transf_3. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR02665. molyb_mobA. 1 hit.

Sequencei

Sequence statusi: Complete.

B1KL44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRIDAVIL AGGMARRMGG NDKGLVELLD KPMIEHSIDR IKPQVKEIMI
60 70 80 90 100
NANRNQSRYA DLGYPVFSDE DSGYLGPLAG MITAMGQTQA DYLLVVPCDC
110 120 130 140 150
PLLPLDLVER MLTKIQSEGA ELAVASDGKR EQPVVLLLKP SLRDSMKAFL
160 170 180 190
DGGERKIDFW YAKHHCVVTE FSDQPNAFIN VNTPEQKQQL AEAIAK
Length:196
Mass (Da):21,701
Last modified:April 29, 2008 - v1
Checksum:i3925589202992F98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000961 Genomic DNA. Translation: ACA84385.1.
RefSeqiWP_012322734.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA84385; ACA84385; Swoo_0084.
KEGGiswd:Swoo_0084.

Similar proteinsi

Entry informationi

Entry nameiMOBA_SHEWM
AccessioniPrimary (citable) accession number: B1KL44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: February 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome