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Protein

ATP phosphoribosyltransferase regulatory subunit

Gene

hisZ

Organism
Pseudomonas putida (strain W619)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.UniRule annotation

Miscellaneous

This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Biological processi

Keywordsi

Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciPPUT390235:G1GBA-4815-MONOMER
UniPathwayiUPA00031; UER00006

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferase regulatory subunitUniRule annotation
Gene namesi
Name:hisZUniRule annotation
Ordered Locus Names:PputW619_4681
OrganismiPseudomonas putida (strain W619)
Taxonomic identifieri390235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000720 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000954671 – 395ATP phosphoribosyltransferase regulatory subunitAdd BLAST395

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

Protein-protein interaction databases

STRINGi390235.PputW619_4681

Structurei

3D structure databases

ProteinModelPortaliB1JAD0
SMRiB1JAD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C49 Bacteria
COG3705 LUCA
HOGENOMiHOG000018074
KOiK02502
OMAiGYELVMP
OrthoDBiPOG091H0GGM

Family and domain databases

HAMAPiMF_00125 HisZ, 1 hit
InterProiView protein in InterPro
IPR004516 HisRS/HisZ
IPR004517 HisZ
PANTHERiPTHR11476 PTHR11476, 1 hit
PIRSFiPIRSF001549 His-tRNA_synth, 1 hit
TIGRFAMsiTIGR00443 hisZ_biosyn_reg, 1 hit

Sequencei

Sequence statusi: Complete.

B1JAD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVDRWLLP DGIEEVLPPE AARIEIARRQ VLDLFQSWGY ELVVTPHIEY
60 70 80 90 100
LESLLTGAGQ DLDQRTFKVV DPQSGRLMGF RADFTPQVAR IDAHTLRREG
110 120 130 140 150
PSRLCYAGSV LHAQPRALST SRSPIQLGAE LYGDASPTSD VEVISLMLAT
160 170 180 190 200
LQLTDVADVH MDLGHVGIYR GLARAAGLSG AVEQQLFDAL QRKSVDEVQA
210 220 230 240 250
LTADLPKDLG NMLRALVELC GGREVLAEAR VRLGRAPASV LAALDDLLAI
260 270 280 290 300
ADRLASRYPE LPLYFDLGEL RGYNYHTGVV FAVFVPGEGQ SIAQGGRYDD
310 320 330 340 350
IGADFGRARP ATGFSTDLKT LVTLGRAEVV LPAGGIWMPD SGDAALWQQV
360 370 380 390
CQLRNEGQRV VQALPGQPLS AALEADCDRQ LIQQDGRWQV LPLTH
Length:395
Mass (Da):42,965
Last modified:April 29, 2008 - v1
Checksum:iA05BB28405051250
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000949 Genomic DNA Translation: ACA75158.1
RefSeqiWP_012316475.1, NC_010501.1

Genome annotation databases

EnsemblBacteriaiACA75158; ACA75158; PputW619_4681
KEGGippw:PputW619_4681

Similar proteinsi

Entry informationi

Entry nameiHISZ_PSEPW
AccessioniPrimary (citable) accession number: B1JAD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: June 20, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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