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Protein

ATP-dependent Clp protease proteolytic subunit

Gene

clpP

Organism
Pseudomonas putida (strain W619)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei114NucleophileUniRule annotation1
Active sitei139UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase ClpUniRule annotation
Gene namesi
Name:clpPUniRule annotation
Ordered Locus Names:PputW619_1742
OrganismiPseudomonas putida (strain W619)
Taxonomic identifieri390235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000720 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001896601 – 213ATP-dependent Clp protease proteolytic subunitAdd BLAST213

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

STRINGi390235.PputW619_1742

Structurei

3D structure databases

ProteinModelPortaliB1J692
SMRiB1J692
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCQ Bacteria
COG0740 LUCA
HOGENOMiHOG000285833
KOiK01358
OMAiLFLQSEN
OrthoDBiPOG091H01WN

Family and domain databases

CDDicd07017 S14_ClpP_2, 1 hit
HAMAPiMF_00444 ClpP, 1 hit
InterProiView protein in InterPro
IPR001907 ClpP
IPR029045 ClpP/crotonase-like_dom_sf
IPR023562 ClpP/TepA
IPR033135 ClpP_His_AS
IPR018215 ClpP_Ser_AS
PANTHERiPTHR10381 PTHR10381, 1 hit
PfamiView protein in Pfam
PF00574 CLP_protease, 1 hit
PRINTSiPR00127 CLPPROTEASEP
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00493 clpP, 1 hit
PROSITEiView protein in PROSITE
PS00382 CLP_PROTEASE_HIS, 1 hit
PS00381 CLP_PROTEASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

B1J692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRNSYIQQS SDIQAAGGLV PMVIEQSARG ERAYDIYSRL LKERVIFLVG
60 70 80 90 100
PVEDYMANLV VAQMLFLEAE NPDKDIHLYI NSPGGSVTAG MSIYDTMQFI
110 120 130 140 150
KPDVSTICIG QACSMGAFLL AAGAKGKRHC LPNSRVMIHQ PLGGFQGQAT
160 170 180 190 200
DIEIHAQEIL NIKARLNELL AYHTGQDLET IKRDTERDNF MSASRAAEYG
210
LIDSVYDKRQ LAS
Length:213
Mass (Da):23,533
Last modified:April 29, 2008 - v1
Checksum:i141384CF16607A26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000949 Genomic DNA Translation: ACA72246.1
RefSeqiWP_009683825.1, NC_010501.1

Genome annotation databases

EnsemblBacteriaiACA72246; ACA72246; PputW619_1742
KEGGippw:PputW619_1742

Similar proteinsi

Entry informationi

Entry nameiCLPP_PSEPW
AccessioniPrimary (citable) accession number: B1J692
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: June 20, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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