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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Burkholderia pseudomallei S13
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotationSAAS annotation

Cofactori

K+UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. NAD/NADP-dependent betaine aldehyde dehydrogenase (betB)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Pathwayi: Carotenoid biosynthesis

This protein is involved in Carotenoid biosynthesis.SAAS annotation
View all proteins of this organism that are known to be involved in Carotenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26Potassium 1UniRule annotation1
Metal bindingi93Potassium 1UniRule annotation1
Active sitei162Charge relay systemUniRule annotation1
Binding sitei209NAD/NADP; via amide nitrogenUniRule annotation1
Metal bindingi245Potassium 2; via carbonyl oxygenUniRule annotation1
Sitei247Seems to be a necessary countercharge to the potassium cationsUniRule annotation1
Active sitei251Proton acceptorUniRule annotation1
Binding sitei285NAD/NADPUniRule annotation1
Binding sitei386NAD/NADPUniRule annotation1
Metal bindingi456Potassium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi459Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei463Charge relay systemUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi150 – 153NAD/NADPUniRule annotation4
Nucleotide bindingi176 – 179NAD/NADPUniRule annotation4
Nucleotide bindingi228 – 233NAD/NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
LigandMetal-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotation, PotassiumUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotationImported
ORF Names:BURPSS13_X0007Imported
OrganismiBurkholderia pseudomallei S13Imported
Taxonomic identifieri320374 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002781 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

OxidationUniRule annotation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliB1H8Q0
SMRiB1H8Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 478AldedhInterPro annotationAdd BLAST461

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili72 – 92Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00804 BADH, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR011264 BADH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01804 BADH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

B1H8Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVYGLQRLY IAGAHADATS GKTFDTFDPA TGELLARVQQ ASADDVDRAV
60 70 80 90 100
ASAREGQREW AAMTAMQRSR ILRRAVELLR ERNDALAELE MRDTGKPIAE
110 120 130 140 150
TRAVDIVTGA DVIEYYAGLA TAIEGLQVPL RPESFVYTRR EPLGVCAGIG
160 170 180 190 200
AWNYPIQIAC WKSAPALAAG NAMIFKPSEV TPLSALKLAE IYTEAGVPAG
210 220 230 240 250
VFNVVQGDGS VGALLSAHPG IAKVSFTGGV ETGKKVMSLA GASSLKEVTM
260 270 280 290 300
ELGGKSPLIV FDDADLDRAA DIAVTANFFS AGQVCTNGTR VFVQQAVKDA
310 320 330 340 350
FVERVLARVA RIRVGKPSDP DTNFGPLASA AQLDKVLGYI DSGKAEGAKL
360 370 380 390 400
LAGGARLVND HFASGQYVAP TVFGDCRDDM RIVREEIFGP VMSILPFETE
410 420 430 440 450
DEAIARANAT DYGLAAGVVT ENLSRAHRAI HRLEAGICWI NTWGESPAEM
460 470 480
PVGGYKQSGV GRENGITTLE HYTRIKSVQV ELGRYQPVF
Length:489
Mass (Da):52,211
Last modified:April 29, 2008 - v1
Checksum:i0373B97C34DA69F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH899763 Genomic DNA Translation: EDS83643.1
RefSeqiWP_004533333.1, NZ_CH899763.1

Genome annotation databases

EnsemblBacteriaiEDS83643; EDS83643; BURPSS13_X0007

Similar proteinsi

Entry informationi

Entry nameiB1H8Q0_BURPE
AccessioniPrimary (citable) accession number: B1H8Q0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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