Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Map2k3 protein

Gene

Map2k3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of protein kinase activity Source: GO_Central
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to sorbitol Source: RGD
  • heart development Source: RGD
  • positive regulation of nitric-oxide synthase biosynthetic process Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • regulation of apoptotic process Source: GO_Central
  • regulation of mitotic cell cycle Source: GO_Central
  • response to ischemia Source: RGD
  • signal transduction by protein phosphorylation Source: GO_Central
  • stress-activated protein kinase signaling cascade Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2559580 Oxidative Stress Induced Senescence
R-RNO-450302 activated TAK1 mediates p38 MAPK activation

Names & Taxonomyi

Protein namesi
Submitted name:
Map2k3 proteinImported
Submitted name:
Mitogen activated protein kinase kinase 3, isoform CRA_bImported
Submitted name:
Mitogen-activated protein kinase kinase 3Imported
Gene namesi
Name:Map2k3Imported
Synonyms:LOC100911550Imported
ORF Names:rCG_34789Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1306620 Map2k3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000006612

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065373

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 325Protein kinaseInterPro annotationAdd BLAST262

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0984 Eukaryota
ENOG410XT3F LUCA
GeneTreeiENSGT00760000119199
HOGENOMiHOG000234206
HOVERGENiHBG108518
KOiK04432
OMAiACVTIGD
OrthoDBiEOG091G0A9H
TreeFamiTF350701

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

B1H230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPAASPPA SLPQTKGKSK RKRDLRISCV SKPPVSNPTP PRNLDSRTFI
60 70 80 90 100
TIGDRNFEVE ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN
110 120 130 140 150
SQEQKRLLMD LDINMRTVDC FYTVTFYGAL FREGDVWICM ELMDTSLDKF
160 170 180 190 200
YRKVLEKNMK IPEDILGEIA VSIVRALEHL HSKLSVIHRD VKPSNVLINK
210 220 230 240 250
EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL NQKGYNVKSD
260 270 280 290 300
VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADQFSPEFVD
310 320 330 340
FTSQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS
Length:347
Mass (Da):39,310
Last modified:April 29, 2008 - v1
Checksum:iEC88B2E35E50240C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07029710 Genomic DNA No translation available.
AABR07029719 Genomic DNA No translation available.
BC160839 mRNA Translation: AAI60839.1
CH473948 Genomic DNA Translation: EDM04673.1
RefSeqiNP_001094144.1, NM_001100674.1
UniGeneiRn.100064

Genome annotation databases

EnsembliENSRNOT00000008679; ENSRNOP00000008679; ENSRNOG00000006612
ENSRNOT00000073792; ENSRNOP00000065373; ENSRNOG00000049132
GeneIDi303200
KEGGirno:303200

Similar proteinsi

Entry informationi

Entry nameiB1H230_RAT
AccessioniPrimary (citable) accession number: B1H230
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: June 20, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health