Map2k3

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of protein kinase activity Source: GO_Central
cellular response to lipopolysaccharide
Source: RGD
Inferred from direct assayⁱ
- 14670949
cellular response to sorbitol
Source: RGD
Inferred from expression patternⁱ
- 20550965
heart development
Source: RGD
Inferred from expression patternⁱ
- 9779826
positive regulation of nitric-oxide synthase biosynthetic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 10593906
positive regulation of protein phosphorylation
Source: RGD
Inferred from direct assayⁱ
- 20550965
regulation of apoptotic process Source: GO_Central
regulation of mitotic cell cycle Source: GO_Central
response to ischemia
Source: RGD
Inferred from expression patternⁱ
- 20550965
signal transduction by protein phosphorylation Source: GO_Central
stress-activated protein kinase signaling cascade Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-RNO-2559580 Oxidative Stress Induced Senescence R-RNO-450302 activated TAK1 mediates p38 MAPK activation

Reactomeⁱ

R-RNO-2559580 Oxidative Stress Induced Senescence
R-RNO-450302 activated TAK1 mediates p38 MAPK activation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Map2k3 proteinImported Submitted name: Mitogen activated protein kinase kinase 3, isoform CRA_bImported Submitted name: Mitogen-activated protein kinase kinase 3Imported
Gene namesⁱ	Name:Map2k3Imported Synonyms:LOC100911550Imported ORF Names:rCG_34789Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 10

Organism-specific databases

Rat genome database More...RGDⁱ	1306620 Map2k3

RGDⁱ

1306620 Map2k3

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000006612 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000006612 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000065373

STRINGⁱ

10116.ENSRNOP00000065373

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	64 – 325	Protein kinaseInterPro annotationAdd BLAST		262

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0984 Eukaryota ENOG410XT3F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119199
HOGENOMⁱ	HOG000234206
HOVERGENⁱ	HBG108518
KEGG Orthology (KO) More...KOⁱ	K04432
OMAⁱ	ACVTIGD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A9H
TreeFamⁱ	TF350701

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

B1H230-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MESPAASPPA SLPQTKGKSK RKRDLRISCV SKPPVSNPTP PRNLDSRTFI 
        60         70         80         90        100
TIGDRNFEVE ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN 
       110        120        130        140        150
SQEQKRLLMD LDINMRTVDC FYTVTFYGAL FREGDVWICM ELMDTSLDKF 
       160        170        180        190        200
YRKVLEKNMK IPEDILGEIA VSIVRALEHL HSKLSVIHRD VKPSNVLINK 
       210        220        230        240        250
EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL NQKGYNVKSD 
       260        270        280        290        300
VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADQFSPEFVD 
       310        320        330        340 
FTSQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS

Length:347

Mass (Da):39,310

Last modified:April 29, 2008 - v1

Checksum:ⁱEC88B2E35E50240C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07029710 Genomic DNA No translation available. AABR07029719 Genomic DNA No translation available. BC160839 mRNA Translation: AAI60839.1 CH473948 Genomic DNA Translation: EDM04673.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001094144.1, NM_001100674.1
UniGeneⁱ	Rn.100064

Genome annotation databases

Ensemblⁱ	ENSRNOT00000008679; ENSRNOP00000008679; ENSRNOG00000006612 ENSRNOT00000073792; ENSRNOP00000065373; ENSRNOG00000049132
GeneIDⁱ	303200
KEGGⁱ	rno:303200

Protein	Similar proteins		Species	Score	Length	Source
B1H230	Map2k3 protein (Fragment)		RAT		107	UniRef100_B1H230
UPI00001D045A		RAT		419

Protein	Similar proteins		Species	Score	Length	Source
B1H230	Dual specificity mitogen-activated protein kinase kinase 3		HUMAN		347	UniRef90_P46734
Dual specificity mitogen-activated protein kinase kinase 3	)	MOUSE		347
Dual specificity mitogen-activated protein kinase kinase 3 isoform B		MACMU		347
Mitogen-activated protein kinase kinase 3		PANTR		347
MAP2K3 isoform 1		PONAB		347
+125

Protein	Similar proteins		Species	Score	Length	Source
B1H230	Dual specificity mitogen-activated protein kinase kinase 3		HUMAN		347	UniRef50_P46734
Dual specificity mitogen-activated protein kinase kinase 3	)	MOUSE		347
Dual specificity mitogen-activated protein kinase kinase 3 isoform B		MACMU		347
Mitogen-activated protein kinase kinase 3		PANTR		347
MAP2K3 isoform 1		PONAB		347
+157

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07029710 Genomic DNA No translation available. AABR07029719 Genomic DNA No translation available. BC160839 mRNA Translation: AAI60839.1 CH473948 Genomic DNA Translation: EDM04673.1
RefSeqⁱ	NP_001094144.1, NM_001100674.1
UniGeneⁱ	Rn.100064

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000065373

STRINGⁱ

10116.ENSRNOP00000065373

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000008679; ENSRNOP00000008679; ENSRNOG00000006612 ENSRNOT00000073792; ENSRNOP00000065373; ENSRNOG00000049132
GeneIDⁱ	303200
KEGGⁱ	rno:303200

Organism-specific databases

CTDⁱ	5606
RGDⁱ	1306620 Map2k3

Phylogenomic databases

eggNOGⁱ	KOG0984 Eukaryota ENOG410XT3F LUCA
GeneTreeⁱ	ENSGT00760000119199
HOGENOMⁱ	HOG000234206
HOVERGENⁱ	HBG108518
KOⁱ	K04432
OMAⁱ	ACVTIGD
OrthoDBⁱ	EOG091G0A9H
TreeFamⁱ	TF350701

Enzyme and pathway databases

Reactomeⁱ	R-RNO-2559580 Oxidative Stress Induced Senescence R-RNO-450302 activated TAK1 mediates p38 MAPK activation

Reactomeⁱ

R-RNO-2559580 Oxidative Stress Induced Senescence
R-RNO-450302 activated TAK1 mediates p38 MAPK activation

Gene expression databases

Bgeeⁱ	ENSRNOG00000006612 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Bgeeⁱ

ENSRNOG00000006612 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B1H230_RAT
Accessionⁱ	B1H230Primary (citable) accession number: B1H230
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 29, 2008
	Last sequence update:	April 29, 2008
	Last modified:	October 10, 2018
	This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B1H230 (B1H230_RAT)

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Map2k3 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ