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UniProtKB - B1H230 (B1H230_RAT)
Protein
Submitted name:
Dual specificity mitogen-activated protein kinase kinase 3-like
Gene
Map2k3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 93 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- MAP kinase kinase activity Source: RGD
- protein kinase binding Source: RGD
- protein serine/threonine kinase activity Source: UniProtKB-KW
GO - Biological processi
- cardiac muscle contraction Source: RGD
- cellular response to lipopolysaccharide Source: RGD
- cellular response to sorbitol Source: RGD
- cellular response to vascular endothelial growth factor stimulus Source: RGD
- heart development Source: RGD
- inflammatory response Source: RGD
- MAPK cascade Source: RGD
- negative regulation of hippo signaling Source: RGD
- p38MAPK cascade Source: RGD
- positive regulation of blood vessel endothelial cell migration Source: RGD
- positive regulation of MAPK cascade Source: RGD
- positive regulation of nitric-oxide synthase biosynthetic process Source: RGD
- positive regulation of protein kinase activity Source: RGD
- positive regulation of protein phosphorylation Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- regulation of cytokine production Source: RGD
- response to ischemia Source: RGD
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-2559580, Oxidative Stress Induced Senescence R-RNO-450302, activated TAK1 mediates p38 MAPK activation |
Names & Taxonomyi
Protein namesi | Submitted name: Dual specificity mitogen-activated protein kinase kinase 3-likeImportedSubmitted name: Map2k3 proteinImportedSubmitted name: Mitogen activated protein kinase kinase 3, isoform CRA_bImportedSubmitted name: Mitogen-activated protein kinase kinase 3Imported |
Gene namesi | ORF Names:rCG_34789Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 11389050, LOC108348082 1306620, Map2k3 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000006612, Expressed in esophagus and 17 other tissues |
Interactioni
GO - Molecular functioni
- protein kinase binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008679 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 325 | Protein kinaseInterPro annotationAdd BLAST | 262 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 45 | DisorderedSequence analysisAdd BLAST | 45 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Phylogenomic databases
eggNOGi | KOG0984, Eukaryota |
GeneTreei | ENSGT00940000160875 |
HOGENOMi | CLU_000288_63_23_1 |
OMAi | MARFINE |
OrthoDBi | 688282at2759 |
TreeFami | TF350701 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
B1H230-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESPAASPPA SLPQTKGKSK RKRDLRISCV SKPPVSNPTP PRNLDSRTFI
60 70 80 90 100
TIGDRNFEVE ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN
110 120 130 140 150
SQEQKRLLMD LDINMRTVDC FYTVTFYGAL FREGDVWICM ELMDTSLDKF
160 170 180 190 200
YRKVLEKNMK IPEDILGEIA VSIVRALEHL HSKLSVIHRD VKPSNVLINK
210 220 230 240 250
EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL NQKGYNVKSD
260 270 280 290 300
VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADQFSPEFVD
310 320 330 340
FTSQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07029710 Genomic DNA No translation available. AABR07029719 Genomic DNA No translation available. BC160839 mRNA Translation: AAI60839.1 CH473948 Genomic DNA Translation: EDM04673.1 |
RefSeqi | NP_001094144.1, NM_001100674.1 |
Genome annotation databases
Ensembli | ENSRNOT00000008679; ENSRNOP00000008679; ENSRNOG00000006612 ENSRNOT00000073792; ENSRNOP00000065373; ENSRNOG00000049132 |
GeneIDi | 303200 |
KEGGi | rno:303200 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07029710 Genomic DNA No translation available. AABR07029719 Genomic DNA No translation available. BC160839 mRNA Translation: AAI60839.1 CH473948 Genomic DNA Translation: EDM04673.1 |
RefSeqi | NP_001094144.1, NM_001100674.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008679 |
Genome annotation databases
Ensembli | ENSRNOT00000008679; ENSRNOP00000008679; ENSRNOG00000006612 ENSRNOT00000073792; ENSRNOP00000065373; ENSRNOG00000049132 |
GeneIDi | 303200 |
KEGGi | rno:303200 |
Organism-specific databases
CTDi | 5606 |
RGDi | 11389050, LOC108348082 1306620, Map2k3 |
Phylogenomic databases
eggNOGi | KOG0984, Eukaryota |
GeneTreei | ENSGT00940000160875 |
HOGENOMi | CLU_000288_63_23_1 |
OMAi | MARFINE |
OrthoDBi | 688282at2759 |
TreeFami | TF350701 |
Enzyme and pathway databases
Reactomei | R-RNO-2559580, Oxidative Stress Induced Senescence R-RNO-450302, activated TAK1 mediates p38 MAPK activation |
Gene expression databases
Bgeei | ENSRNOG00000006612, Expressed in esophagus and 17 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B1H230_RAT | |
Accessioni | B1H230Primary (citable) accession number: B1H230 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 29, 2008 |
Last sequence update: | April 29, 2008 | |
Last modified: | January 19, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |