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UniProtKB - B1H215 (B1H215_RAT)

Entry version 71 (13 Feb 2019)
Sequence version 1 (29 Apr 2008)
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Protein
Submitted name:

Nuclear receptor coactivator 4

Gene

Ncoa4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear receptor coactivator 4Imported
Submitted name:
RCG42267, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncoa4Imported
ORF Names:rCG_42267Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Rat genome database

More...RGDi		1563014 Ncoa4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000019768 Expressed in 10 organ(s), highest expression level in spleen

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000061299

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 165ARA70InterPro annotationAdd BLAST131
Domaini199 – 323ARA70InterPro annotationAdd BLAST125

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IHT6 Eukaryota
ENOG410YJ5B LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008403

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000013175

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG052584

KEGG Orthology (KO)

More...KOi		K09289

Identification of Orthologs from Complete Genome Data

More...OMAi		YRTPLQV

Database of Orthologous Groups

More...OrthoDBi		1397106at2759

TreeFam database of animal gene trees

More...TreeFami		TF333204

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022174 ARA70
IPR039947 NCoA-4

The PANTHER Classification System

More...PANTHERi		PTHR17085 PTHR17085, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12489 ARA70, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B1H215-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTSLEQSGC CSSRETLLRC SDARRELELA IGGVLRAEQQ MKDNLREVKA 
        60         70         80         90        100
QIHSCISRHL ECLRSREVWL NEQVDLIYQL KEETLQQQAQ QLYWLMGQFN 
       110        120        130        140        150
CLIHQLEITQ NKDLANQVAL CLERLGSLTL KPEDSTVLLF EADASALRQT 
       160        170        180        190        200
ITTFGSLKTI QIPEHLMAHP SSSSVRPFLE KRGYTQVPEQ KSASSGTAVS 
       210        220        230        240        250
LSEWLLVSKP AIGPQAPYVP STNPQDWLTP KQTLENSQTS ARICSDAWGN 
       260        270        280        290        300
LKGLENWLLN SHQQEIPGKP SSSKCNSHCS TSSFSTEDEK VEDVEVLDQD 
       310        320        330        340        350
ELDLSDWLVT PQEPRDLEKP VNGRSDTSDK FKLLFQVFRE PYNVNDWLVK 
       360        370        380        390        400
PDSCTNCQGN QPRGVEIENL GNLKCLNDHL EAKKSLPVPG VITEGWLVQN 
       410        420        430        440        450
HQDTCKVEEV CKANEPCTSF AECVCDDSCE KEAMHKWLLK KEGKDKNGMP 
       460        470        480        490        500
MGPKSESEKH RESLSLWLCP SRNELTEHAK TPKTTAPARI ADSFHIIRNS 
       510        520        530        540        550
SLSEWLIGPT CKGGGPKEVP NMEERASKEM LKSPMATYWR PFNTADWVLP 
       560        570        580        590        600
GKKVGNLSQF SSGEDKWLLR KKAQEVFLNS PLQEERNFRS DCYGLPAVCD 
       610        620 
LFACMQLKVD KDKWLYRAPL QM
Length:622
Mass (Da):70,284
Last modified:April 29, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B15C9EF982BA865
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC129637 Genomic DNA No translation available.
BC160817 mRNA Translation: AAI60817.1
CH474046 Genomic DNA Translation: EDL88925.1
CH474046 Genomic DNA Translation: EDL88926.1

NCBI Reference Sequences

More...RefSeqi		NP_001029179.1, NM_001034007.1
NP_001029180.1, NM_001034008.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Rn.165968
Rn.198999

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000026803; ENSRNOP00000026803; ENSRNOG00000019768
ENSRNOT00000066062; ENSRNOP00000061299; ENSRNOG00000019768

Database of genes from NCBI RefSeq genomes

More...GeneIDi		619385

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:619385

UCSC genome browser

More...UCSCi		RGD:1563014 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129637 Genomic DNA No translation available.
BC160817 mRNA Translation: AAI60817.1
CH474046 Genomic DNA Translation: EDL88925.1
CH474046 Genomic DNA Translation: EDL88926.1
RefSeqiNP_001029179.1, NM_001034007.1
NP_001029180.1, NM_001034008.1
UniGeneiRn.165968
Rn.198999

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061299

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026803; ENSRNOP00000026803; ENSRNOG00000019768
ENSRNOT00000066062; ENSRNOP00000061299; ENSRNOG00000019768
GeneIDi619385
KEGGirno:619385
UCSCiRGD:1563014 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8031
RGDi1563014 Ncoa4

Phylogenomic databases

eggNOGiENOG410IHT6 Eukaryota
ENOG410YJ5B LUCA
GeneTreeiENSGT00390000008403
HOGENOMiHOG000013175
HOVERGENiHBG052584
KOiK09289
OMAiYRTPLQV
OrthoDBi1397106at2759
TreeFamiTF333204

Gene expression databases

BgeeiENSRNOG00000019768 Expressed in 10 organ(s), highest expression level in spleen

Family and domain databases

InterProiView protein in InterPro
IPR022174 ARA70
IPR039947 NCoA-4
PANTHERiPTHR17085 PTHR17085, 1 hit
PfamiView protein in Pfam
PF12489 ARA70, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB1H215_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1H215
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: February 13, 2019
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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