Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetate kinase

Gene

ackA

Organism
Uncultured termite group 1 bacterium phylotype Rs-D17
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Active sitei147Proton donor/acceptorUniRule annotation1
Sitei179Transition state stabilizerUniRule annotation1
Sitei240Transition state stabilizerUniRule annotation1
Metal bindingi386MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi207 – 211ATPUniRule annotation5
Nucleotide bindingi284 – 286ATPUniRule annotation3
Nucleotide bindingi332 – 336ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:TGRD_319
OrganismiUncultured termite group 1 bacterium phylotype Rs-D17
Taxonomic identifieri471821 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaenvironmental samples
Proteomesi
  • UP000001691 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000900051 – 400Acetate kinaseAdd BLAST400

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi471821.TGRD_319

Structurei

3D structure databases

ProteinModelPortaliB1GZX0
SMRiB1GZX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
HOGENOMiHOG000288398
KOiK00925
OMAiWKALTGT

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B1GZX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLVVNCGS SSVKYTLFEM ENEKKIAWGI VECGPSKSYY KRQTAVSEEK
60 70 80 90 100
KNSVKVTSHT EAVELIINDL LDKEIGSIVN IDEIDVIGHR IVHGGDRFSR
110 120 130 140 150
SVLVTKEVKK GLKECFSIAP LHTPAHYAGI LAVEKMLPGI PSVLVFDTAF
160 170 180 190 200
HQTMPDYAYM YALPFEYYEK YHIRKYGFHG TSHNYVSQRA AIMLGKSLNE
210 220 230 240 250
LKLITAHLGN GSSITAIEKG KVIDTSMGFT PLQGVVMGTR CGDIDPAIIA
260 270 280 290 300
YIIKIHPKYR NSEALNALMN KESGLLGISG ISGDMRSIVK AATESNKKAK
310 320 330 340 350
LAFETLCYSI KKYISSYYGI LNGIDGLVFT AGIGENSPVV REKICVNLHA
360 370 380 390 400
IGIEIDTEKN NEPSSKERFV STAYSRVKIM IIPTNEELMI ARESRDCLRT
Length:400
Mass (Da):44,319
Last modified:April 29, 2008 - v1
Checksum:i37881D38125CAE7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009510 Genomic DNA Translation: BAG13802.1
RefSeqiWP_015423329.1, NC_020419.1
YP_001956263.1, NC_020419.1

Genome annotation databases

EnsemblBacteriaiBAG13802; BAG13802; TGRD_319
KEGGirsd:TGRD_319
PATRICifig|471821.5.peg.509

Similar proteinsi

Entry informationi

Entry nameiACKA_UNCTG
AccessioniPrimary (citable) accession number: B1GZX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: June 7, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health