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Entry version 109 (29 Sep 2021)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Serine/threonine-protein kinase LMTK1

Gene

Aatk

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei109ATPPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Serine/threonine-protein kinase LMTK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AatkImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1197518, Aatk

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000025375

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
308619

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B1AZF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025375, Expressed in spinal cord and 177 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B1AZF9, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B1AZF9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 348Protein kinaseInterPro annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni502 – 575DisorderedSequence analysisAdd BLAST74
Regioni590 – 650DisorderedSequence analysisAdd BLAST61
Regioni743 – 1138DisorderedSequence analysisAdd BLAST396
Regioni1189 – 1245DisorderedSequence analysisAdd BLAST57
Regioni1296 – 1317DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi512 – 527Polar residuesSequence analysisAdd BLAST16
Compositional biasi624 – 641Polar residuesSequence analysisAdd BLAST18
Compositional biasi796 – 835Polar residuesSequence analysisAdd BLAST40
Compositional biasi851 – 865Polar residuesSequence analysisAdd BLAST15
Compositional biasi902 – 918Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi978 – 1010Polar residuesSequence analysisAdd BLAST33
Compositional biasi1052 – 1083Polar residuesSequence analysisAdd BLAST32
Compositional biasi1102 – 1116Acidic residuesSequence analysisAdd BLAST15
Compositional biasi1194 – 1215Polar residuesSequence analysisAdd BLAST22

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154244

Identification of Orthologs from Complete Genome Data

More...
OMAi
WGEAAFC

Database of Orthologous Groups

More...
OrthoDBi
53680at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332280

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05087, PTKc_Aatyk1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR042817, LMTK1_c
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109, TYRKINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

B1AZF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLACLCCKKG GIGFKEFENA EGDEYVADFS EQGSPAAAAQ TGPDVYVLPL
60 70 80 90 100
TEVSLPMAKQ PGRSVQLLKS TDLGRHSLLY LKEIGHGWFG KVFLGEVHSG
110 120 130 140 150
VSGTQVVVKE LKVSASVQEQ MQFLEEAQPY RALQHSNLLQ CLAQCAEVTP
160 170 180 190 200
YLLVMEFCPL GDLKGYLRSC RVTESMAPDP LTLQRMACEV ACGVLHLHRH
210 220 230 240 250
NYVHSDLALR NCLLTADLTV KVGDYGLSHC KYREDYLVTA DQLWVPLRWI
260 270 280 290 300
APELVDEVHG NLLVVDQTKS SNVWSLGVTI WELFELGAQP YPQHSDGQVL
310 320 330 340 350
AYAVREQQLK LPKPQLQLAL SDRWYEVMQF CWLQPEQRPT AEEVHLLLSY
360 370 380 390 400
LCAKGTTELE EEFERRWRSL RPGGSTGLGS GSAAPAAATA ASAELTAASS
410 420 430 440 450
FPLLERFTSD GFHVDSDDVL TVTETSHGLN FEYKWEAGCG AEEYPPSGAA
460 470 480 490 500
SSPGSAARLQ ELCAPDSSPP GVVPVLSAHS PSVGSEYFIR LEGAVPAAGH
510 520 530 540 550
DPDCAGCAPS PQAVTDQDNN SEESTVASLA MEPLLGHAPP TEGLWGPCDH
560 570 580 590 600
HSHRRQGSPC PSRSPSPGTP MLPAEDIDWG VATFCPPFFD DPLGASPSGS
610 620 630 640 650
PGAQPSPSDE EPEEGKVGLA AQCGHWSSNM SANNNSASRD PESWDPGYVS
660 670 680 690 700
SFTDSYRDDC SSLEQTPRAS PEVGHLLSQE DPRDFLPGLV AVSPGQEPSR
710 720 730 740 750
PFNLLPLCPA KGLAPAACLI TSPWTEGAVG GAENPIVEPK LAQEAEGSAE
760 770 780 790 800
PQLPLPSVPS PSCEGASLPS EEASAPDILP ASPTPAAGSW VTVPEPAPTL
810 820 830 840 850
ESSGSSLGQE APSSEDEDTT EATSGVFTDL SSDGPHTEKS GIVPALRSLQ
860 870 880 890 900
KQVGTPDSLD SLDIPSSASD GGCEVLSPSA AGPPGGQPRA VDSGYDTENY
910 920 930 940 950
ESPEFVLKEA HESSEPEAFG EPASEGESPG PDPLLSVSLG GLSKKSPYRD
960 970 980 990 1000
SAYFSDLDAE SEPTFGPEKH SGIQDSQKEQ DLRSPPSPGH QSVQAFPRSA
1010 1020 1030 1040 1050
VSSEVLSPPQ QSEEPLPEVP RPEPLGAQGP VGVQPVPGPS HSKCFPLTSV
1060 1070 1080 1090 1100
PLISEGSGTE PQGPSGQLSG RAQQGQMGNP STPRSPLCLA LPGHPGALEG
1110 1120 1130 1140 1150
RPEEDEDTED SEESDEELRC YSVQEPSEDS EEEPPAVPVV VAESQSARNL
1160 1170 1180 1190 1200
RSLLKMPSLL SEAFCDDLER KKKAVSFFDD VTVYLFDQES PTRETGEPFP
1210 1220 1230 1240 1250
STKESLPTFL EGGPSSPSAT GLPLRAGHSP DSSAPEPGSR FEWDGDFPLV
1260 1270 1280 1290 1300
PGKAALVTEL DPADPVLAAP PTPAAPFSRF TVSPTPASRF SITHISDSDA
1310
QSVGGPAAGA GGRYTEA
Length:1,317
Mass (Da):139,452
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BFC9F925DDB940C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80YE4LMTK1_MOUSE
Serine/threonine-protein kinase LMT...
Aatk Aatyk, Kiaa0641, Lmr1, Lmtk1
1,365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AZF3B1AZF3_MOUSE
Serine/threonine-protein kinase LMT...
Aatk
1,374Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A668KLA4A0A668KLA4_MOUSE
Serine/threonine-protein kinase LMT...
Aatk
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A668KLB8A0A668KLB8_MOUSE
Serine/threonine-protein kinase LMT...
Aatk
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001185716.1, NM_001198787.1
NP_031403.2, NM_007377.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000103019; ENSMUSP00000099308; ENSMUSG00000025375
ENSMUST00000103020; ENSMUSP00000099309; ENSMUSG00000025375

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11302

UCSC genome browser

More...
UCSCi
uc007mrk.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001185716.1, NM_001198787.1
NP_031403.2, NM_007377.4

3D structure databases

SMRiB1AZF9
ModBaseiSearch...

PTM databases

SwissPalmiB1AZF9

Proteomic databases

ProteomicsDBi308619

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2104, 208 antibodies

The DNASU plasmid repository

More...
DNASUi
11302

Genome annotation databases

EnsembliENSMUST00000103019; ENSMUSP00000099308; ENSMUSG00000025375
ENSMUST00000103020; ENSMUSP00000099309; ENSMUSG00000025375
GeneIDi11302
UCSCiuc007mrk.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9625
MGIiMGI:1197518, Aatk
VEuPathDBiHostDB:ENSMUSG00000025375

Phylogenomic databases

GeneTreeiENSGT00940000154244
OMAiWGEAAFC
OrthoDBi53680at2759
TreeFamiTF332280

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11302, 1 hit in 61 CRISPR screens

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025375, Expressed in spinal cord and 177 other tissues
ExpressionAtlasiB1AZF9, baseline and differential

Family and domain databases

CDDicd05087, PTKc_Aatyk1, 1 hit
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR042817, LMTK1_c
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
PfamiView protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit
PRINTSiPR00109, TYRKINASE
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB1AZF9_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1AZF9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 29, 2021
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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