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Entry version 93 (16 Jan 2019)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Serine/threonine-protein kinase LMTK1

Gene

Aatk

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Serine/threonine-protein kinase LMTK1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AatkImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1197518 Aatk

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500276050721 – 1374Sequence analysisAdd BLAST1354

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B1AZF3

PeptideAtlas

More...
PeptideAtlasi
B1AZF3

PRoteomics IDEntifications database

More...
PRIDEi
B1AZF3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025375 Expressed in 141 organ(s), highest expression level in spinal cord

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B1AZF3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B1AZF3 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B1AZF3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B1AZF3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini135 – 405Protein kinaseInterPro annotationAdd BLAST271

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGQE Eukaryota
ENOG410XQFM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154244

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080533

KEGG Orthology (KO)

More...
KOi
K17480

Database of Orthologous Groups

More...
OrthoDBi
53680at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B1AZF3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B1AZF3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLIALLALAM SSSFFNPSFA FSSHFDPDGA PLSELSWSSS LAVVAVSFSG
60 70 80 90 100
IFTVVILMLA CLCCKKGGIG FKEFENAEGD EYVADFSEQG SPAAAAQTGP
110 120 130 140 150
DVYVLPLTEV SLPMAKQPGR SVQLLKSTDL GRHSLLYLKE IGHGWFGKVF
160 170 180 190 200
LGEVHSGVSG TQVVVKELKV SASVQEQMQF LEEAQPYRAL QHSNLLQCLA
210 220 230 240 250
QCAEVTPYLL VMEFCPLGDL KGYLRSCRVT ESMAPDPLTL QRMACEVACG
260 270 280 290 300
VLHLHRHNYV HSDLALRNCL LTADLTVKVG DYGLSHCKYR EDYLVTADQL
310 320 330 340 350
WVPLRWIAPE LVDEVHGNLL VVDQTKSSNV WSLGVTIWEL FELGAQPYPQ
360 370 380 390 400
HSDGQVLAYA VREQQLKLPK PQLQLALSDR WYEVMQFCWL QPEQRPTAEE
410 420 430 440 450
VHLLLSYLCA KGTTELEEEF ERRWRSLRPG GSTGLGSGSA APAAATAASA
460 470 480 490 500
ELTAASSFPL LERFTSDGFH VDSDDVLTVT ETSHGLNFEY KWEAGCGAEE
510 520 530 540 550
YPPSGAASSP GSAARLQELC APDSSPPGVV PVLSAHSPSV GSEYFIRLEG
560 570 580 590 600
AVPAAGHDPD CAGCAPSPQA VTDQDNNSEE STVASLAMEP LLGHAPPTEG
610 620 630 640 650
LWGPCDHHSH RRQGSPCPSR SPSPGTPMLP AEDIDWGVAT FCPPFFDDPL
660 670 680 690 700
GASPSGSPGA QPSPSDEEPE EGKVGLAAQC GHWSSNMSAN NNSASRDPES
710 720 730 740 750
WDPGYVSSFT DSYRDDCSSL EQTPRASPEV GHLLSQEDPR DFLPGLVAVS
760 770 780 790 800
PGQEPSRPFN LLPLCPAKGL APAACLITSP WTEGAVGGAE NPIVEPKLAQ
810 820 830 840 850
EAEGSAEPQL PLPSVPSPSC EGASLPSEEA SAPDILPASP TPAAGSWVTV
860 870 880 890 900
PEPAPTLESS GSSLGQEAPS SEDEDTTEAT SGVFTDLSSD GPHTEKSGIV
910 920 930 940 950
PALRSLQKQV GTPDSLDSLD IPSSASDGGC EVLSPSAAGP PGGQPRAVDS
960 970 980 990 1000
GYDTENYESP EFVLKEAHES SEPEAFGEPA SEGESPGPDP LLSVSLGGLS
1010 1020 1030 1040 1050
KKSPYRDSAY FSDLDAESEP TFGPEKHSGI QDSQKEQDLR SPPSPGHQSV
1060 1070 1080 1090 1100
QAFPRSAVSS EVLSPPQQSE EPLPEVPRPE PLGAQGPVGV QPVPGPSHSK
1110 1120 1130 1140 1150
CFPLTSVPLI SEGSGTEPQG PSGQLSGRAQ QGQMGNPSTP RSPLCLALPG
1160 1170 1180 1190 1200
HPGALEGRPE EDEDTEDSEE SDEELRCYSV QEPSEDSEEE PPAVPVVVAE
1210 1220 1230 1240 1250
SQSARNLRSL LKMPSLLSEA FCDDLERKKK AVSFFDDVTV YLFDQESPTR
1260 1270 1280 1290 1300
ETGEPFPSTK ESLPTFLEGG PSSPSATGLP LRAGHSPDSS APEPGSRFEW
1310 1320 1330 1340 1350
DGDFPLVPGK AALVTELDPA DPVLAAPPTP AAPFSRFTVS PTPASRFSIT
1360 1370
HISDSDAQSV GGPAAGAGGR YTEA
Length:1,374
Mass (Da):145,418
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD592D731000162C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80YE4LMTK1_MOUSE
Serine/threonine-protein kinase LMT...
Aatk Aatyk, Kiaa0641, Lmr1, Lmtk1
1,365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AZF9B1AZF9_MOUSE
Apoptosis-associated tyrosine kinas...
Aatk mCG_15033
1,317Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL953913 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001185714.1, NM_001198785.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.6826

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000064307; ENSMUSP00000067181; ENSMUSG00000025375

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:11302

UCSC genome browser

More...
UCSCi
uc007mro.3 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL953913 Genomic DNA No translation available.
RefSeqiNP_001185714.1, NM_001198785.1
UniGeneiMm.6826

3D structure databases

ProteinModelPortaliB1AZF3
SMRiB1AZF3
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiB1AZF3
PeptideAtlasiB1AZF3
PRIDEiB1AZF3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064307; ENSMUSP00000067181; ENSMUSG00000025375
GeneIDi11302
KEGGimmu:11302
UCSCiuc007mro.3 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9625
MGIiMGI:1197518 Aatk

Phylogenomic databases

eggNOGiENOG410IGQE Eukaryota
ENOG410XQFM LUCA
GeneTreeiENSGT00940000154244
HOVERGENiHBG080533
KOiK17480
OrthoDBi53680at2759
PhylomeDBiB1AZF3

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025375 Expressed in 141 organ(s), highest expression level in spinal cord
ExpressionAtlasiB1AZF3 baseline and differential
GenevisibleiB1AZF3 MM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB1AZF3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1AZF3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 16, 2019
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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