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Protein

Methyl-CpG-binding domain protein 5

Gene

Mbd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5689603 UCH proteinases

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-CpG-binding domain protein 5
Alternative name(s):
Methyl-CpG-binding protein MBD5
Gene namesi
Name:Mbd5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2138934 Mbd5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004069401 – 1498Methyl-CpG-binding domain protein 5Add BLAST1498

Proteomic databases

PaxDbiB1AYB6
PRIDEiB1AYB6

PTM databases

iPTMnetiB1AYB6
PhosphoSitePlusiB1AYB6

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Developmental stagei

Expressed in embryo at 7, 11, 15 and 17 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000036792 Expressed in 228 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiB1AYB6 baseline and differential
GenevisibleiB1AYB6 MM

Interactioni

Protein-protein interaction databases

BioGridi224612, 1 interactor
IntActiB1AYB6, 1 interactor
STRINGi10090.ENSMUSP00000036847

Structurei

3D structure databases

ProteinModelPortaliB1AYB6
SMRiB1AYB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 81MBDPROSITE-ProRule annotationAdd BLAST71
Domaini1389 – 1451PWWPAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi332 – 414Pro-richAdd BLAST83

Domaini

Both MBD and PWWP domains are necessary for chromocentric localization.By similarity

Phylogenomic databases

eggNOGiENOG410IGJZ Eukaryota
ENOG410XR1J LUCA
GeneTreeiENSGT00530000064137
HOGENOMiHOG000049255
HOVERGENiHBG052419
InParanoidiB1AYB6

Family and domain databases

InterProiView protein in InterPro
IPR037385 MBD5/MBD6
IPR001739 Methyl_CpG_DNA-bd
PANTHERiPTHR16112 PTHR16112, 1 hit
SMARTiView protein in SMART
SM00391 MBD, 1 hit
PROSITEiView protein in PROSITE
PS50982 MBD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

B1AYB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGGKECDGG DKEGGLAAIQ VPVGWQRRVD HNGVLYISPS GSLLSCLDQV
60 70 80 90 100
KTYLLTDGTC KCGLECPLIL PKVFNFDPGA AVKQRTAEDV KADDDVTKLC
110 120 130 140 150
IHKRKIIAVA TLHQSMEAPH PSLVLTSPGG GTNATPVVPS RAATPRSVRN
160 170 180 190 200
KSHEGITNSV MPECKNPFKL MTGSSNAMGR LYMQDLPGSQ QQELHPVYPR
210 220 230 240 250
QRLGSSEHGQ KSPFRGSHGG LPSPASSGSQ IYGDGSISPR TDPLGSPDVF
260 270 280 290 300
TRNNPGFHGA PNSSPIHLNR TPLSPPSVML HGSPVQSSCA MAGRTNIPLS
310 320 330 340 350
PTLTTKSPVM KKPMCNFSTN MEIPRAMFHH KPPQGPPPPP PPSCALQKKP
360 370 380 390 400
LTSEKDPLGI LDPIPSKPVN QNPIIINPTS FHSNVHSQVP VMNVSMPPAV
410 420 430 440 450
VPLPSNLPLP TVKPGHMNHG SHVQRIQHSA STSLSPSPVT SPVHMMGTGI
460 470 480 490 500
GRIEASPQRS RSSSTSSDHG NFMMPPVGPQ ATCSGIKVPP RSPRSTIGSP
510 520 530 540 550
RPSMPSSPST KSDGHHQYKD IPNPLIAGMS NVLNTPSSAA FPTAPAGNGS
560 570 580 590 600
VKSQPGLLGM PLNQILNQHN AASFPASSLL SAAAKAQLAN QNKLAGNNSS
610 620 630 640 650
SSNNSGAVAS SGNTEGHSTL NTMFPPTANM LLPTGEGQSG RAALRDKLMS
660 670 680 690 700
QQKDSLRKRK QPPTTVLSLL RQSQMDSSAA PKPGPDLLRK HGQGSFPISS
710 720 730 740 750
MSQLLQSMSC QSSHLSSNST PGCGGSNTAL PCSANQLHFP DPNMNSTVLQ
760 770 780 790 800
NSLTQSIPLR GEAVHCHNAN TNFVHSNSPV PNHHLAGLIN QIQASGNCGM
810 820 830 840 850
LSQSGMALGN SLHPNPPQSR ISTSSTPVIP NSIVSSYNQT SSEAGGSSLP
860 870 880 890 900
SSIAIAGSNH PAITKTTSVL QDGVIVTTAA GNPLQSQLPI GSDFPFVGQE
910 920 930 940 950
HALHFPSNST ANNHLPHPLN PSLLSSLPIS LPVNQQHLLN QNLLNILQPS
960 970 980 990 1000
AGEGDISSIN NSLNNHQLTH LQSLLNSNQM FPPNQQPQQH LLQGHQNLQA
1010 1020 1030 1040 1050
FQGQPTVPCP ANNNPMACLF QNFQVRMQGD AALLNKRIST QPGLTTLPEN
1060 1070 1080 1090 1100
PNLALPHFQD TPCELQPRID LGQPMKDGLV MGGQGDASVD AIYKAVVDAA
1110 1120 1130 1140 1150
SKGMQVVITT AVNSTTQISP IPALSAMSAF TASIGDPLNL SSAVSAVIHG
1160 1170 1180 1190 1200
RNMGGVDHDG RLRNARGARL PKNIDHGKNS SEGDGFECFK SASCHTSRKQ
1210 1220 1230 1240 1250
WDGEQSPRGE RNRWKYEEFL DHPGHIHSSP CHERPNNVST LPFLAGEQHP
1260 1270 1280 1290 1300
ILLPPRNCQG DKILEENFRY NNYKRTMMSF KERLESTVER CTHINGNRPR
1310 1320 1330 1340 1350
QSRGFGELLG TAKQDLVLEG QSPGSSNSLE SSLVKDYIHY NGDFNAKTIN
1360 1370 1380 1390 1400
GCVPSPSDAK SISSEDDLRN PDSPSSHELI HYRPRTFNVG DLVWGQIKGL
1410 1420 1430 1440 1450
TSWPGKFIRE DDVHNSCQQS PEEGKVEPEK LKTLTEGLEA YSRVRKRSRK
1460 1470 1480 1490
SGKLNNHLEA AIHEAMSELD KMSGTVHQIP QGDRQMRPPK PKRRKISR
Length:1,498
Mass (Da):160,292
Last modified:April 8, 2008 - v1
Checksum:iA7B2A2D483A84DCE
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AYB5B1AYB5_MOUSE
Methyl-CpG-binding domain protein 5
Mbd5
1,728Annotation score:
B1AYB7B1AYB7_MOUSE
Methyl-CpG-binding domain protein 5
Mbd5
856Annotation score:
A0A0G2JG39A0A0G2JG39_MOUSE
Methyl-CpG-binding domain protein 5
Mbd5
113Annotation score:
F6Q8U1F6Q8U1_MOUSE
Methyl-CpG-binding domain protein 5
Mbd5
1,067Annotation score:
A0A0G2JEL9A0A0G2JEL9_MOUSE
Methyl-CpG-binding domain protein 5
Mbd5
77Annotation score:
A0A0G2JFF3A0A0G2JFF3_MOUSE
Methyl-CpG-binding domain protein 5
Mbd5
156Annotation score:
Q3TTF1Q3TTF1_MOUSE
Methyl-CpG-binding domain protein 5
Mbd5
435Annotation score:
A0A0G2JF81A0A0G2JF81_MOUSE
Methyl-CpG-binding domain protein 5
Mbd5
120Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX546465, AL845298 Genomic DNA Translation: CAM16085.1
AL845298, BX546465 Genomic DNA Translation: CAM19541.1
BC138375 mRNA Translation: AAI38376.1
BC138378 mRNA Translation: AAI38379.1
CCDSiCCDS71051.1
RefSeqiNP_001277585.1, NM_001290656.1
XP_017170404.1, XM_017314915.1
UniGeneiMm.440436

Genome annotation databases

EnsembliENSMUST00000112754; ENSMUSP00000108374; ENSMUSG00000036792
GeneIDi109241
KEGGimmu:109241
UCSCiuc012bve.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX546465, AL845298 Genomic DNA Translation: CAM16085.1
AL845298, BX546465 Genomic DNA Translation: CAM19541.1
BC138375 mRNA Translation: AAI38376.1
BC138378 mRNA Translation: AAI38379.1
CCDSiCCDS71051.1
RefSeqiNP_001277585.1, NM_001290656.1
XP_017170404.1, XM_017314915.1
UniGeneiMm.440436

3D structure databases

ProteinModelPortaliB1AYB6
SMRiB1AYB6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224612, 1 interactor
IntActiB1AYB6, 1 interactor
STRINGi10090.ENSMUSP00000036847

PTM databases

iPTMnetiB1AYB6
PhosphoSitePlusiB1AYB6

Proteomic databases

PaxDbiB1AYB6
PRIDEiB1AYB6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112754; ENSMUSP00000108374; ENSMUSG00000036792
GeneIDi109241
KEGGimmu:109241
UCSCiuc012bve.1 mouse

Organism-specific databases

CTDi55777
MGIiMGI:2138934 Mbd5

Phylogenomic databases

eggNOGiENOG410IGJZ Eukaryota
ENOG410XR1J LUCA
GeneTreeiENSGT00530000064137
HOGENOMiHOG000049255
HOVERGENiHBG052419
InParanoidiB1AYB6

Enzyme and pathway databases

ReactomeiR-MMU-5689603 UCH proteinases

Miscellaneous databases

ChiTaRSiMbd5 mouse
PROiPR:B1AYB6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036792 Expressed in 228 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiB1AYB6 baseline and differential
GenevisibleiB1AYB6 MM

Family and domain databases

InterProiView protein in InterPro
IPR037385 MBD5/MBD6
IPR001739 Methyl_CpG_DNA-bd
PANTHERiPTHR16112 PTHR16112, 1 hit
SMARTiView protein in SMART
SM00391 MBD, 1 hit
PROSITEiView protein in PROSITE
PS50982 MBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMBD5_MOUSE
AccessioniPrimary (citable) accession number: B1AYB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 8, 2008
Last modified: September 12, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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