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Protein

Ubiquitin carboxyl-terminal hydrolase 51

Gene

Usp51

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Deubiquitinates histone H2A at 'Lys-13' and 'Lys-15' and regulates DNA damage response. USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1 foci.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei329NucleophilePROSITE-ProRule annotation1 Publication1
Active sitei615Proton acceptorPROSITE-ProRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 250UBP-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiC19.065

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 511 Publication (EC:3.4.19.121 Publication)
Alternative name(s):
Deubiquitinating enzyme 51
Gene namesi
Name:Usp51Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:3588217 Usp51

Subcellular locationi

Keywords - Cellular componenti

Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi329C → S: Abolishes ability to deubiquitinate histone H2A; when associated with R-615. 1 Publication1
Mutagenesisi615H → R: Abolishes ability to deubiquitinate histone H2A; when associated with S-329. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004418921 – 661Ubiquitin carboxyl-terminal hydrolase 51Add BLAST661

Proteomic databases

PaxDbiB1AY15
PRIDEiB1AY15

PTM databases

PhosphoSitePlusiB1AY15

Expressioni

Gene expression databases

BgeeiENSMUSG00000067215 Expressed in 13 organ(s), highest expression level in placenta

Interactioni

Subunit structurei

Interacts with H2A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093427

Structurei

3D structure databases

ProteinModelPortaliB1AY15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini320 – 656USPPROSITE-ProRule annotationAdd BLAST337

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 96Pro-richPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri190 – 250UBP-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1867 Eukaryota
ENOG410XQQ0 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000007260
HOVERGENiHBG058014
InParanoidiB1AY15
KOiK11366
OMAiCESKEQE
OrthoDBiEOG091G09GI
TreeFamiTF323554

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR033383 USP51
IPR018200 USP_CS
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PANTHERiPTHR43961:SF4 PTHR43961:SF4, 1 hit
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit

Sequencei

Sequence statusi: Complete.

B1AY15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGTQGAQEM KPELWPEPKP TSENLTSRGS GSYEKVLPSI PAACHTSSSS
60 70 80 90 100
VCPRRKPRPR PQPRSRSRGG RGLKAPPPPP AKPPPPPPAP PPPPLPKQRS
110 120 130 140 150
VAWRNSRRRS RPGPRPQTRK SYSSDHGSSR DSDGSENSLL EVGSNKGPTG
160 170 180 190 200
CCHVESFKVA KNWQRNLRMI YQRFIWSGTP ETRKRKAKSC ICQICSTHKN
210 220 230 240 250
RLHSCLSCVF FGCFTDKHIH IHAETTQHNL AVDLCHGVIY CFMCRDYVYD
260 270 280 290 300
KDIEKIAKET KEKILGLLSS PTGDASYQQL MASEVEENQL TCESKDQETS
310 320 330 340 350
LVKPKKKRRK KTMYYTVGFR GLINLGNTCF MNCIVQVLTH IPLLKEFFLS
360 370 380 390 400
NKHKCMMTSP SLCLVCEMSL LFQAMYSGNQ SPHIPYKLLH LIWIHAEHLA
410 420 430 440 450
GYRQQDAQEF LIAILDVLHR HSRDDGIDQE GNSNCCNCII DHIFTGSLQS
460 470 480 490 500
DLTCQVCHGV STTIDPCWDI SLDLPGPYTP GRASSSTSSR DGQKPRVISL
510 520 530 540 550
TDCLKWFTRP EDLGSSAKIK CSQCQSYQES TKQLTMKKLP IVACFHLKRF
560 570 580 590 600
EHLGKQRRKI NSFISFPLEL DMTPFLASTK ESIMKGQPLT ECVPSENKYS
610 620 630 640 650
LFAVINHHGT LESGHYTSFV RQEKDQWFSC DDAVVTKATM EELLNSEGYL
660
LFYHRQDIEK E
Length:661
Mass (Da):74,783
Last modified:April 8, 2008 - v1
Checksum:i835F5340AC471579
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL840632 Genomic DNA No translation available.
CCDSiCCDS53226.1
RefSeqiNP_001131019.1, NM_001137547.1
UniGeneiMm.426169

Genome annotation databases

EnsembliENSMUST00000095755; ENSMUSP00000093427; ENSMUSG00000067215
GeneIDi635253
KEGGimmu:635253
UCSCiuc009uqp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL840632 Genomic DNA No translation available.
CCDSiCCDS53226.1
RefSeqiNP_001131019.1, NM_001137547.1
UniGeneiMm.426169

3D structure databases

ProteinModelPortaliB1AY15
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093427

Protein family/group databases

MEROPSiC19.065

PTM databases

PhosphoSitePlusiB1AY15

Proteomic databases

PaxDbiB1AY15
PRIDEiB1AY15

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095755; ENSMUSP00000093427; ENSMUSG00000067215
GeneIDi635253
KEGGimmu:635253
UCSCiuc009uqp.2 mouse

Organism-specific databases

CTDi158880
MGIiMGI:3588217 Usp51

Phylogenomic databases

eggNOGiKOG1867 Eukaryota
ENOG410XQQ0 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000007260
HOVERGENiHBG058014
InParanoidiB1AY15
KOiK11366
OMAiCESKEQE
OrthoDBiEOG091G09GI
TreeFamiTF323554

Miscellaneous databases

PROiPR:B1AY15
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067215 Expressed in 13 organ(s), highest expression level in placenta

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR033383 USP51
IPR018200 USP_CS
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PANTHERiPTHR43961:SF4 PTHR43961:SF4, 1 hit
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBP51_MOUSE
AccessioniPrimary (citable) accession number: B1AY15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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