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Entry version 90 (08 May 2019)
Sequence version 1 (08 Apr 2008)
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Protein

Ubiquitin carboxyl-terminal hydrolase 24

Gene

Usp24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1695NucleophilePROSITE-ProRule annotation1
Active sitei1967Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5689880 Ub-specific processing proteases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 24 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 24
Ubiquitin thioesterase 24
Ubiquitin-specific-processing protease 24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Usp24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919936 Usp24

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003532131 – 2617Ubiquitin carboxyl-terminal hydrolase 24Add BLAST2617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei62PhosphoserineBy similarity1
Modified residuei85PhosphoserineBy similarity1
Modified residuei939PhosphotyrosineCombined sources1
Modified residuei1138PhosphoserineCombined sources1
Modified residuei1282PhosphoserineBy similarity1
Modified residuei1940PhosphoserineCombined sources1
Modified residuei2044PhosphoserineCombined sources1
Modified residuei2074PhosphoserineCombined sources1
Modified residuei2558PhosphoserineBy similarity1
Modified residuei2562PhosphothreonineCombined sources1
Modified residuei2601PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
B1AY13

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
B1AY13

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B1AY13

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B1AY13

PeptideAtlas

More...
PeptideAtlasi
B1AY13

PRoteomics IDEntifications database

More...
PRIDEi
B1AY13

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B1AY13

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B1AY13

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B1AY13

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028514 Expressed in 288 organ(s), highest expression level in cornea

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B1AY13 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B1AY13 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
236858, 1 interactor

Protein interaction database and analysis system

More...
IntActi
B1AY13, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000092538

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B1AY13

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 44UBAPROSITE-ProRule annotationAdd BLAST42
Domaini1686 – 2039USPAdd BLAST354

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 91Gly-richAdd BLAST45
Compositional biasi1032 – 1059Ser-richAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1866 Eukaryota
COG5077 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159474

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000068011

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B1AY13

KEGG Orthology (KO)

More...
KOi
K11840

Database of Orthologous Groups

More...
OrthoDBi
625455at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B1AY13

TreeFam database of animal gene trees

More...
TreeFami
TF323966

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
IPR033382 USP24
IPR018200 USP_CS
IPR028889 USP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR24006:SF729 PTHR24006:SF729, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit
SSF48371 SSF48371, 1 hit
SSF54001 SSF54001, 1 hit
SSF54236 SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50030 UBA, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: B1AY13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESEEEQHMT TLLCMGFSDP ATIRKALRLA KNDINEAVAL LTNERPGLDY
60 70 80 90 100
GGYEPMDSGG PSPGPGGGPR GDSGSDGSGP SRGGSTGGGG GFDPPPAYHE
110 120 130 140 150
VVDAEKNDEN GNCSGEGIEF PTTNLYELES RVLTDHWSIP YKREESLGKC
160 170 180 190 200
LLASTYLARL GLSESDENCK RFMERCMPEA FKKLLTSSAV HKWGTEIHEG
210 220 230 240 250
IYNMLMLLIE LVAERMKQDP IPIGLLGVLT MAFNPDNEYH FKNRMKVSQR
260 270 280 290 300
NWAEVFGEGN MFAISPVSTF QKEPHGWVVD LVNKFGELGG FAAIQAKLHS
310 320 330 340 350
EDIELGAVSA LVQPLGVCAE YLNSSVVQPM LDPVILTTIQ DVRSVEEKDL
360 370 380 390 400
KDKRLVSIPE LLSAIKLLCM RFQPALVTTV DALRLDILLR MLKSPHFSAK
410 420 430 440 450
MNSLKEVTKL IEDSTLSKSV KNAIDTDRLL DWLVENSVLS IALEGNIDQA
460 470 480 490 500
QYCDRIKGII ELLGSKLSLD ELTKIWKIQS GQSSTVIENI HTIIAAAAVK
510 520 530 540 550
FNADQLNHLF VLIQKSWETE SDRVRQKLLS LIGRIGREAR FEATSGKVLD
560 570 580 590 600
VLWELAHLPT LPSSLIQQAL EEHLTILSDA YAVKEAVKRS YIIKCIEDIK
610 620 630 640 650
RPGEWSSLEK NKKDGFKSSQ LNNPQFVWVV PALRQLHEIT RSFIKQTYQK
660 670 680 690 700
QDKSIIQDLK KNFEIVKLVT GSLLACHRLA AAVAGPGGLT GLTLVDGRYT
710 720 730 740 750
YREYLEAHLK FLAFFLQEAT LYLGWNRAKE IWECLVTGQD VCELDREMCF
760 770 780 790 800
EWFTKGQHDL ESDVQQQLFK EKILKLESYE ITMNGFNLFK TFFENVNLCD
810 820 830 840 850
HRLKRQGAQL YVEKLELVGM DFIWKIAMES PDEEIANEAI QLIINYSYIN
860 870 880 890 900
LNPRLKKDSV SLHKKFIADC YTRLEAASSA LGGPTLTHAV TRATKMLTAT
910 920 930 940 950
AMPTVATSVQ SPYRSTKLVI IERLLLLAER YVITIEDFYS VPRTILPHGA
960 970 980 990 1000
SFHGHLLTLN VTYESTKDTF TVEAHSNETI GSVRWKIAKQ LCSPVDNIQI
1010 1020 1030 1040 1050
FTNDSLLTVN KDQKLLHQLG FSDEQVLTVK TSGSGTPSGS SADSSTSSSS
1060 1070 1080 1090 1100
SSSGAFSSSY AMEQEKSLPG VVMALVCNVF DMLYQLANLE EPRITLRVRK
1110 1120 1130 1140 1150
LLLLIPTDPA IQEALDQLDS LGRKKTLLSE TSSQSSKSPS LSSKQQHQPS
1160 1170 1180 1190 1200
ASSILESLFR SFAPGMSTFR VLYNLEVLSS KLMPTADDDM ARSCAKSFCE
1210 1220 1230 1240 1250
NFLKAGGLSL VVNVMQRDSI PSEVDYETRQ GVYSICLQLA RFLLVGQTMP
1260 1270 1280 1290 1300
TSLDEDLTKD GIEALSSRPF RNVSRQTSRQ MSLCGTPEKS SYRQLSVSDR
1310 1320 1330 1340 1350
SSIRVEEIIP AARVAIQTME ASDFTATVAC FMRLSWAAAA GRLDLVGSSQ
1360 1370 1380 1390 1400
PIKESNSLFP AGIRSRLSSS GSNCSSSSEG EPAALHAGIC VRQQSVSTKD
1410 1420 1430 1440 1450
ALIAGEALSL LVTCLQLRSQ QLASFYSLPC VADFIIDILL GSPSAEIRRV
1460 1470 1480 1490 1500
ACDQLYTLSQ TDTSAHPEVQ KPNQFLLGVI LTAQLPLWSP TSIMRGVNQR
1510 1520 1530 1540 1550
LLSQCMEYFD LRCQLLDDLT TSEMDQLRIS PATMLEDEIT WLDNFEPNRT
1560 1570 1580 1590 1600
ADCETSEADN ILLAGHLRLI KTLLSLCGAE KEMLGSSLIK PLLDDFLFRA
1610 1620 1630 1640 1650
SRIIVNSHSP ASSAAISQQD FHPKCSTVNS RLAAYEVLVM LADSSPSNLQ
1660 1670 1680 1690 1700
IITKELLSMH HQPDPALTKE FDYLPPVDSR SSSGFVGLRN GGATCYMNAV
1710 1720 1730 1740 1750
FQQLYMQPGL PESLLSVDDD TDNPDDSVFY QVQSLFGHLM ESKLQYYVPE
1760 1770 1780 1790 1800
NFWKIFKMWN KELYVREQQD AYEFFTSLID QMDEYLKKMG REQIFKNTFQ
1810 1820 1830 1840 1850
GIYSDQKICK DCPHRYEREE AFMALNLGVT SCQSLEISLD QFVRGEVLEG
1860 1870 1880 1890 1900
SNAYYCEKCK EKRITVKRTC IKSLPSVLVI HLMRFGFDWE SGRSIKYDEQ
1910 1920 1930 1940 1950
IRFPWMLNME PYTVAGMARQ DSSSEVGENG RNMDQGGGGS PRKKVALTEN
1960 1970 1980 1990 2000
YELVGVIVHS GQAHAGHYYS FIKDRRGCGK GKWYKFNDTV IEEFDLNDET
2010 2020 2030 2040 2050
LEYECFGGEY RPKVYDQTNP YTDVRRRYWN AYMLFYQRVS DQNSPVLPKK
2060 2070 2080 2090 2100
SRVSVVRQEA EDLSLSAPSS PEISPQSSPR PHRPNNDRLS ILTKLVKKGE
2110 2120 2130 2140 2150
KKGLFVEKMP ARIYQMVRDE NLKFMKNRDV YSSDYFSFVL SLASLNATKL
2160 2170 2180 2190 2200
KHPYYPCMAK VSLQLAIQFL FQTYLRTKKK LRVDTEEWIA TIEALLSKSL
2210 2220 2230 2240 2250
DACQWLVEYF ISSEGRELVK VFLLECSVRE VRVAVATILE KTLDSALFYQ
2260 2270 2280 2290 2300
DKLKSLHQLL EVLLALLDKD VPENCKNCAQ YFSLFNTFVQ KQGIRAGDLL
2310 2320 2330 2340 2350
LRHSALRHMI SFLLGVSRQN SQIRRWSSAQ AREFGNLHNT VALLVLHSDV
2360 2370 2380 2390 2400
SSQRNVAPGI FKQRPPISVA PSSPLLPLHE EVEALLFLSE GKPYLLEVMF
2410 2420 2430 2440 2450
ALRELTGSLL ALMEMVVYCC FCNEHFSFTM LHFIKNQLET APPHELKNTF
2460 2470 2480 2490 2500
QLLHEVLVIE DPIQVERVKF VFETENGLLA LMHHSNHVDS SRCYQCVKFL
2510 2520 2530 2540 2550
VTLAQKCPAA KEYFKENSHH WSWAVQWLQK KMSEHYWTPQ SNVSNETSTG
2560 2570 2580 2590 2600
KTFQRTISAQ DTLAYATALL NEKEQSGSSN GSESSPANEN GERHLQQGSE
2610
SPMMIGELRS DLDDVDP
Length:2,617
Mass (Da):294,001
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i802DFE22143B2C94
GO
Isoform 2 (identifier: B1AY13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-418: TKLIEDSTLSK → SVHLSHMWPLM
     419-2617: Missing.

Show »
Length:418
Mass (Da):45,968
Checksum:i21F4B4F0BAA3737F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PV45E9PV45_MOUSE
Ubiquitin carboxyl-terminal hydrola...
Usp24
2,618Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_035661408 – 418TKLIEDSTLSK → SVHLSHMWPLM in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_035662419 – 2617Missing in isoform 2. 1 PublicationAdd BLAST2199

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK045043 mRNA Translation: BAC32195.1
AL840623 Genomic DNA No translation available.
AL954352 Genomic DNA No translation available.
BC029165 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51251.1 [B1AY13-1]

NCBI Reference Sequences

More...
RefSeqi
NP_899048.2, NM_183225.2 [B1AY13-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000094933; ENSMUSP00000092538; ENSMUSG00000028514 [B1AY13-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
329908

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:329908

UCSC genome browser

More...
UCSCi
uc008tyf.2 mouse [B1AY13-2]
uc008tyh.2 mouse [B1AY13-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045043 mRNA Translation: BAC32195.1
AL840623 Genomic DNA No translation available.
AL954352 Genomic DNA No translation available.
BC029165 mRNA No translation available.
CCDSiCCDS51251.1 [B1AY13-1]
RefSeqiNP_899048.2, NM_183225.2 [B1AY13-1]

3D structure databases

SMRiB1AY13
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236858, 1 interactor
IntActiB1AY13, 1 interactor
STRINGi10090.ENSMUSP00000092538

PTM databases

iPTMnetiB1AY13
PhosphoSitePlusiB1AY13
SwissPalmiB1AY13

Proteomic databases

EPDiB1AY13
jPOSTiB1AY13
MaxQBiB1AY13
PaxDbiB1AY13
PeptideAtlasiB1AY13
PRIDEiB1AY13

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
329908
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094933; ENSMUSP00000092538; ENSMUSG00000028514 [B1AY13-1]
GeneIDi329908
KEGGimmu:329908
UCSCiuc008tyf.2 mouse [B1AY13-2]
uc008tyh.2 mouse [B1AY13-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23358
MGIiMGI:1919936 Usp24

Phylogenomic databases

eggNOGiKOG1866 Eukaryota
COG5077 LUCA
GeneTreeiENSGT00940000159474
HOGENOMiHOG000068011
InParanoidiB1AY13
KOiK11840
OrthoDBi625455at2759
PhylomeDBiB1AY13
TreeFamiTF323966

Enzyme and pathway databases

ReactomeiR-MMU-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Usp24 mouse

Protein Ontology

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PROi
PR:B1AY13

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000028514 Expressed in 288 organ(s), highest expression level in cornea
ExpressionAtlasiB1AY13 baseline and differential
GenevisibleiB1AY13 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
IPR033382 USP24
IPR018200 USP_CS
IPR028889 USP_dom
PANTHERiPTHR24006:SF729 PTHR24006:SF729, 3 hits
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF48371 SSF48371, 1 hit
SSF54001 SSF54001, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP24_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1AY13
Secondary accession number(s): Q8BLI7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: April 8, 2008
Last modified: May 8, 2019
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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