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Protein

Transcriptional repressor NF-X1

Gene

Nfx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri352 – 403RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52
Zinc fingeri447 – 465NF-X1-type 1Add BLAST19
Zinc fingeri500 – 519NF-X1-type 2Add BLAST20
Zinc fingeri561 – 580NF-X1-type 3Add BLAST20
Zinc fingeri626 – 649NF-X1-type 4Add BLAST24
Zinc fingeri688 – 707NF-X1-type 5Add BLAST20
Zinc fingeri715 – 734NF-X1-type 6Add BLAST20
Zinc fingeri826 – 848NF-X1-type 7Add BLAST23
Zinc fingeri857 – 878NF-X1-type 8Add BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor, Transferase
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional repressor NF-X1 (EC:2.3.2.-)
Short name:
m-Nfx.1
Alternative name(s):
Nuclear transcription factor, X box-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nfx1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1921414 Nfx1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003346141 – 1114Transcriptional repressor NF-X1Add BLAST1114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineBy similarity1
Modified residuei81PhosphoserineCombined sources1
Modified residuei92PhosphoserineBy similarity1
Modified residuei126PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei147PhosphoserineBy similarity1
Modified residuei320PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
B1AY10

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
B1AY10

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B1AY10

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
B1AY10

PeptideAtlas

More...
PeptideAtlasi
B1AY10

PRoteomics IDEntifications database

More...
PRIDEi
B1AY10

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B1AY10

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
B1AY10

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with highest levels in thymus.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Ubiquitously expressed at E12 and E14.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028423 Expressed in 275 organ(s), highest expression level in pituitary gland

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
B1AY10 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PABPC1 and PABPC4.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
216539, 1 interactor

Protein interaction database and analysis system

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IntActi
B1AY10, 1 interactor

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000095747

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
B1AY10

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
B1AY10

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini988 – 1056R3HPROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni9 – 26Interaction with PABPC1 and PABC4By similarityAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1078 – 1083Poly-Pro6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NFX1 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri352 – 403RING-type; atypicalPROSITE-ProRule annotationAdd BLAST52
Zinc fingeri447 – 465NF-X1-type 1Add BLAST19
Zinc fingeri500 – 519NF-X1-type 2Add BLAST20
Zinc fingeri561 – 580NF-X1-type 3Add BLAST20
Zinc fingeri626 – 649NF-X1-type 4Add BLAST24
Zinc fingeri688 – 707NF-X1-type 5Add BLAST20
Zinc fingeri715 – 734NF-X1-type 6Add BLAST20
Zinc fingeri826 – 848NF-X1-type 7Add BLAST23
Zinc fingeri857 – 878NF-X1-type 8Add BLAST22

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1952 Eukaryota
ENOG410XR02 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156325

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG003827

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
B1AY10

KEGG Orthology (KO)

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KOi
K12236

Identification of Orthologs from Complete Genome Data

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OMAi
HPCEHPP

Database of Orthologous Groups

More...
OrthoDBi
299100at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B1AY10

TreeFam database of animal gene trees

More...
TreeFami
TF105889

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02643 R3H_NF-X1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.50, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034078 NFX1_fam
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR034076 R3H_NF-X1
IPR019786 Zinc_finger_PHD-type_CS
IPR000967 Znf_NFX1
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING

The PANTHER Classification System

More...
PANTHERi
PTHR12360 PTHR12360, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01424 R3H, 1 hit
PF01422 zf-NF-X1, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00393 R3H, 1 hit
SM00438 ZnF_NFX, 9 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF82708 SSF82708, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51061 R3H, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: B1AY10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAPPVSGT FKFNTDAAEF IPQERKTSGL NCGTQRRLDS SRIGRRNYSS
60 70 80 90 100
SPPCHLPRHI PYEDISAVHQ HSYASGSKPK SPQGFFQSSN KSLKNHGLQN
110 120 130 140 150
QPWQKARNEK HQNRNKKAQG LSEQTSDTSS LESVARSESG TNPREHSPSE
160 170 180 190 200
SEKEVVIADP RGAKPKKAAQ LTYNYGRGPK AKGRLRSEWG NRMSPKSEDE
210 220 230 240 250
NTRPVAISHT DSSDASCRKP VVDPCVCRRN EQRRYPQKRP PWEVEGARPR
260 270 280 290 300
PGRNPPKQES QRHINAGPKT NMSPIPKDNL RERPTKSACD TGNLAVVSKS
310 320 330 340 350
SRRVNQEKTA VRRQDPQVLS PFPRGKQNHM LKNVETHTGS LIEQLTTEKY
360 370 380 390 400
ECMVCCELVQ VTAPVWSCQS CFHVFHLNCI KKWARSPASH ADGQSGWRCP
410 420 430 440 450
ACQNVSAHVP NTYTCFCGKV KNPEWSRNEI PHSCGEVCRK KQPGQDCPHS
460 470 480 490 500
CNLLCHPGPC PPCPAFTTKT CECGRTRHTV RCGQPVSVHC SNACENILNC
510 520 530 540 550
GQHHCAELCH GGQCQPCRII LNQVCYCGST SRDVLCGTDV GKSDGFGDFS
560 570 580 590 600
CLKICGKDLK CGSHTCSQVC HPQPCQPCPR LPHLVRYCPC GQTPLSQLLE
610 620 630 640 650
HGSNARKTCM DPVPSCGKVC GKPLACGSSD FIHTCEKLCH EGDCGPCSRT
660 670 680 690 700
SVISCRCSFR TKELPCTSLK SEDATFMCDK RCNKKRLCGR HKCNEICCVD
710 720 730 740 750
KEHKCPLICG RKLRCGLHRC EEPCHRGNCQ TCWQASFDEL TCHCGASVIY
760 770 780 790 800
PPVPCGTRPP ECTQTCARIH ECDHPVYHSC HSEEKCPPCT FLTQKWCMGK
810 820 830 840 850
HELRSNIPCH LVDISCGLPC SAMLPCGMHK CQRLCHKGEC LVDEACKQPC
860 870 880 890 900
TTPRGDCGHP CMAPCHPSLP CPVTACKAKV ELQCECGRRK EMVICSEASG
910 920 930 940 950
TYQRIVAISM ASKITDMQLG DSVEISKLIT KKEVQQARLQ CDEECAALER
960 970 980 990 1000
RKRLAEAFDI TDDSDPFNVR SSASKFSDSL KDDARKDLKF VSDVEKEMET
1010 1020 1030 1040 1050
LVEAVNKGKN NKKSHCFPPM NRDHRRIIHD LAQVYGLESI SYDSEPKRNV
1060 1070 1080 1090 1100
VVTAVRGKSV CPPTTLTSVI ERETQTRPPP PIPHHRHQAD KAPGSSTLQK
1110
IVKEAVIDYF DVQD
Length:1,114
Mass (Da):123,811
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA31013ACC6FB31F4
GO
Isoform 2 (identifier: B1AY10-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     803-804: LR → RQ
     805-1114: Missing.

Show »
Length:804
Mass (Da):89,439
Checksum:i0EC4111EF5F6C6E8
GO
Isoform 3 (identifier: B1AY10-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     803-818: LRSNIPCHLVDISCGL → ELTIKKLWTFKETLDF
     819-1114: Missing.

Show »
Length:818
Mass (Da):91,149
Checksum:iE803AE670CF16778
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF34700 differs from that shown. Reason: Frameshift at positions 200, 214, 242 and 246.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49S → N in BAC28494 (PubMed:16141072).Curated1
Sequence conflicti141T → A in BAE33235 (PubMed:16141072).Curated1
Sequence conflicti273S → P in AAH53709 (PubMed:15489334).Curated1
Sequence conflicti455C → Y in BAE33235 (PubMed:16141072).Curated1
Sequence conflicti590C → R in AAH53709 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033693803 – 818LRSNI…ISCGL → ELTIKKLWTFKETLDF in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_033694803 – 804LR → RQ in isoform 2. 2 Publications2
Alternative sequenceiVSP_033695805 – 1114Missing in isoform 2. 2 PublicationsAdd BLAST310
Alternative sequenceiVSP_033696819 – 1114Missing in isoform 3. 1 PublicationAdd BLAST296

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF223576 mRNA Translation: AAF34700.1 Frameshift.
AK005038 mRNA Translation: BAB23765.1
AK033850 mRNA Translation: BAC28494.1
AK144647 mRNA Translation: BAE25987.1
AK146108 mRNA Translation: BAE26907.1
AK155387 mRNA Translation: BAE33235.1
AL837521 Genomic DNA No translation available.
BC053709 mRNA Translation: AAH53709.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS18054.1 [B1AY10-1]
CCDS71359.1 [B1AY10-2]
CCDS71360.1 [B1AY10-3]

NCBI Reference Sequences

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RefSeqi
NP_001277377.1, NM_001290448.1 [B1AY10-3]
NP_001277378.1, NM_001290449.1 [B1AY10-2]
NP_076228.2, NM_023739.3 [B1AY10-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.247456
Mm.439181

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000030133; ENSMUSP00000030133; ENSMUSG00000028423 [B1AY10-3]
ENSMUST00000091614; ENSMUSP00000089203; ENSMUSG00000028423 [B1AY10-2]
ENSMUST00000098143; ENSMUSP00000095747; ENSMUSG00000028423 [B1AY10-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
74164

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:74164

UCSC genome browser

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UCSCi
uc008sic.2 mouse [B1AY10-2]
uc008sid.2 mouse [B1AY10-3]
uc008sie.2 mouse [B1AY10-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223576 mRNA Translation: AAF34700.1 Frameshift.
AK005038 mRNA Translation: BAB23765.1
AK033850 mRNA Translation: BAC28494.1
AK144647 mRNA Translation: BAE25987.1
AK146108 mRNA Translation: BAE26907.1
AK155387 mRNA Translation: BAE33235.1
AL837521 Genomic DNA No translation available.
BC053709 mRNA Translation: AAH53709.1
CCDSiCCDS18054.1 [B1AY10-1]
CCDS71359.1 [B1AY10-2]
CCDS71360.1 [B1AY10-3]
RefSeqiNP_001277377.1, NM_001290448.1 [B1AY10-3]
NP_001277378.1, NM_001290449.1 [B1AY10-2]
NP_076228.2, NM_023739.3 [B1AY10-1]
UniGeneiMm.247456
Mm.439181

3D structure databases

ProteinModelPortaliB1AY10
SMRiB1AY10
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216539, 1 interactor
IntActiB1AY10, 1 interactor
STRINGi10090.ENSMUSP00000095747

PTM databases

iPTMnetiB1AY10
PhosphoSitePlusiB1AY10

Proteomic databases

EPDiB1AY10
jPOSTiB1AY10
MaxQBiB1AY10
PaxDbiB1AY10
PeptideAtlasiB1AY10
PRIDEiB1AY10

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030133; ENSMUSP00000030133; ENSMUSG00000028423 [B1AY10-3]
ENSMUST00000091614; ENSMUSP00000089203; ENSMUSG00000028423 [B1AY10-2]
ENSMUST00000098143; ENSMUSP00000095747; ENSMUSG00000028423 [B1AY10-1]
GeneIDi74164
KEGGimmu:74164
UCSCiuc008sic.2 mouse [B1AY10-2]
uc008sid.2 mouse [B1AY10-3]
uc008sie.2 mouse [B1AY10-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4799
MGIiMGI:1921414 Nfx1

Phylogenomic databases

eggNOGiKOG1952 Eukaryota
ENOG410XR02 LUCA
GeneTreeiENSGT00940000156325
HOVERGENiHBG003827
InParanoidiB1AY10
KOiK12236
OMAiHPCEHPP
OrthoDBi299100at2759
PhylomeDBiB1AY10
TreeFamiTF105889

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nfx1 mouse

Protein Ontology

More...
PROi
PR:B1AY10

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028423 Expressed in 275 organ(s), highest expression level in pituitary gland
GenevisibleiB1AY10 MM

Family and domain databases

CDDicd02643 R3H_NF-X1, 1 hit
Gene3Di3.30.1370.50, 1 hit
InterProiView protein in InterPro
IPR034078 NFX1_fam
IPR001374 R3H_dom
IPR036867 R3H_dom_sf
IPR034076 R3H_NF-X1
IPR019786 Zinc_finger_PHD-type_CS
IPR000967 Znf_NFX1
IPR019787 Znf_PHD-finger
IPR001841 Znf_RING
PANTHERiPTHR12360 PTHR12360, 1 hit
PfamiView protein in Pfam
PF01424 R3H, 1 hit
PF01422 zf-NF-X1, 7 hits
SMARTiView protein in SMART
SM00393 R3H, 1 hit
SM00438 ZnF_NFX, 9 hits
SUPFAMiSSF82708 SSF82708, 1 hit
PROSITEiView protein in PROSITE
PS51061 R3H, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFX1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1AY10
Secondary accession number(s): Q3U2A7
, Q3UK95, Q3UMW1, Q7TPT4, Q8CC59, Q9DBC8, Q9JKW7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: January 16, 2019
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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