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Entry version 59 (08 May 2019)
Sequence version 2 (10 Apr 2019)
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Protein

NHS-like protein 2

Gene

Nhsl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell differentiation Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NHS-like protein 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nhsl2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3645090 Nhsl2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003413561 – 1219NHS-like protein 2Add BLAST1219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei499PhosphoserineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei1048PhosphoserineCombined sources1
Modified residuei1208PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
B1AXH1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B1AXH1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B1AXH1

PeptideAtlas

More...
PeptideAtlasi
B1AXH1

PRoteomics IDEntifications database

More...
PRIDEi
B1AXH1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B1AXH1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B1AXH1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000079481 Expressed in 238 organ(s), highest expression level in internal carotid artery

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
785739, 1 interactor

Protein interaction database and analysis system

More...
IntActi
B1AXH1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000098893

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B1AXH1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NHS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJGU Eukaryota
ENOG410ZHHT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182963

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113784

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B1AXH1

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRQPVNV

Database of Orthologous Groups

More...
OrthoDBi
82879at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333323

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024845 NHS_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15273 NHS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B1AXH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFYRRTVVP QRLCPRNPPQ PLAELRDVSH LAALSLLRQL ADLCGHSLAL
60 70 80 90 100
LEDLEGHLLA LGRRTDSLYR RTVRLRRRLP CRLLGPEDDE ELLAAANSGR
110 120 130 140 150
ENATATAHSR SSWRQPVNVF LSSGRPPSVE ELLREAQLNL QSLLQEEYEE
160 170 180 190 200
QYSEARLLGQ TFRSSDGAPE PTPSPRPQSA KRLEFVLMPA KRQLSEDETT
210 220 230 240 250
TQGVRAPEAC LSLSTANKQS AWNDPFPLPI LKERLWLQPC STQSDLVPIN
260 270 280 290 300
ISGQQFDRHA SFRHSLFNTE TAVNPKSTLR RRRTIIGFSN FSQRDQGHSS
310 320 330 340 350
SPTGSLARSA TSDIRPGHSA PQVVQGRVAV GQEARFPSLT SPGLRHSSSE
360 370 380 390 400
PGDAHQARSA SDHPGMESMA VVYSVPSSCN GPTESTFSTS WKGDAFTYMT
410 420 430 440 450
PSASSQGNQV SENGKNPSSG NSWVPLNTLP PLVPKEAATL FVTRDNPAGC
460 470 480 490 500
TGLPSYSEHP TLRRQIPERP PKIGLLARGT SRLETGPGGT NRFRERSLSV
510 520 530 540 550
PTDSGVTSVD YDEEQKTSET RILPYASTSS EGSNSTDNIA ALSTEQEARH
560 570 580 590 600
RRQRSKSISL KKAKKKPSPP MRSVSLVKDE PALPPEGELV LPKDQRPRSL
610 620 630 640 650
CLSLEHQGHH PPHPDAQGHP AVPMLKDPGS TQFSHHWYLT DWKSGDTYQS
660 670 680 690 700
LSSSSTATGT TVIECTQVQG SSESLASPST SRATTPSQLS IEVEAREVAS
710 720 730 740 750
PGRPTGLMSP SSGYSSQSET PTPTVSMSLT LGHLPPPSAS VRVRPVVPER
760 770 780 790 800
KSSLPPTSPM EKICKSRLSF DLPLTSSTTL DLSGMSISIR SKTKVSRHHS
810 820 830 840 850
DTNFGVKLAQ KTSPNQPIMP MVTQSDLRSV RLRSVSKSEP EDDIESPDYI
860 870 880 890 900
EEPGAEEVFT MPERKVKPPI AEKPPLARRP PSLVHRPPSL PGEYPLTSPT
910 920 930 940 950
MAMASRSSIP HMKQLPQDSY TVLRKPKSPS FPGESTASSS LVLSPLASSS
960 970 980 990 1000
GAFFSGTQQP PQASVEDGGP KVRALPERIG LQSQEEAEKK MTKIPPPVPK
1010 1020 1030 1040 1050
KPSVLYLPLT SPVAQMDACM AEPRLPFSPI ITLEEDGKCP STGDDQKSPG
1060 1070 1080 1090 1100
KGVTSPLHTD TEKEAISPGR SVEPSAEEKS LISDKTAEWI AEEEDDVFVA
1110 1120 1130 1140 1150
SRTTEDLFTV IHRSKRKLLG WKETGEGFTG SKPSSHSPVK NTADSPTGEA
1160 1170 1180 1190 1200
AAAPGPSSSA CLDAGRNDDF KALLQKKGSK ATPRTRPSAA ELLKTTNPLA
1210
RRIIAQFSKD YEPTDNPST
Length:1,219
Mass (Da):132,353
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA3C4C6BF415B6E1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AXG8B1AXG8_MOUSE
NHS-like protein 2
Nhsl2
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFH6A0A0G2JFH6_MOUSE
NHS-like protein 2
Nhsl2
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL807784 Genomic DNA No translation available.
AL808026 Genomic DNA No translation available.
CN666857 mRNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001157082.1, NM_001163610.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000101339; ENSMUSP00000098893; ENSMUSG00000079481

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100042480

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100042480

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807784 Genomic DNA No translation available.
AL808026 Genomic DNA No translation available.
CN666857 mRNA No translation available.
RefSeqiNP_001157082.1, NM_001163610.1

3D structure databases

SMRiB1AXH1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi785739, 1 interactor
IntActiB1AXH1, 1 interactor
STRINGi10090.ENSMUSP00000098893

PTM databases

iPTMnetiB1AXH1
PhosphoSitePlusiB1AXH1

Proteomic databases

jPOSTiB1AXH1
MaxQBiB1AXH1
PaxDbiB1AXH1
PeptideAtlasiB1AXH1
PRIDEiB1AXH1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101339; ENSMUSP00000098893; ENSMUSG00000079481
GeneIDi100042480
KEGGimmu:100042480

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340527
MGIiMGI:3645090 Nhsl2

Phylogenomic databases

eggNOGiENOG410IJGU Eukaryota
ENOG410ZHHT LUCA
GeneTreeiENSGT00950000182963
HOGENOMiHOG000113784
InParanoidiB1AXH1
OMAiWRQPVNV
OrthoDBi82879at2759
TreeFamiTF333323

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Nhsl2 mouse

Protein Ontology

More...
PROi
PR:B1AXH1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000079481 Expressed in 238 organ(s), highest expression level in internal carotid artery

Family and domain databases

InterProiView protein in InterPro
IPR024845 NHS_fam
PfamiView protein in Pfam
PF15273 NHS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNHSL2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1AXH1
Secondary accession number(s): E9Q0V6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 10, 2019
Last modified: May 8, 2019
This is version 59 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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