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Protein

Akirin-2

Gene

Akirin2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). Required for embryonic development and the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6.By similarity1 Publication

Miscellaneous

'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processImmunity, Innate immunity, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Akirin-2
Gene namesi
Name:Akirin21 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1889364 Akirin2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are embryonic lethal. Null mutant embryos could not be detected even on embryonic day 9.5.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003551211 – 201Akirin-2Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei55PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiB1AXD8
MaxQBiB1AXD8
PaxDbiB1AXD8
PeptideAtlasiB1AXD8
PRIDEiB1AXD8

PTM databases

iPTMnetiB1AXD8
PhosphoSitePlusiB1AXD8

Expressioni

Gene expression databases

BgeeiENSMUSG00000028291 Expressed in 291 organ(s), highest expression level in oocyte
GenevisibleiB1AXD8 MM

Interactioni

Subunit structurei

Interacts with YWHAB.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi241383, 1 interactor
IntActiB1AXD8, 7 interactors
MINTiB1AXD8
STRINGi10090.ENSMUSP00000081322

Structurei

3D structure databases

ProteinModelPortaliB1AXD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi23 – 28Nuclear localization signal6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 54Ala-richSequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the akirin family.Curated

Phylogenomic databases

eggNOGiKOG4330 Eukaryota
ENOG4111J00 LUCA
GeneTreeiENSGT00390000007905
HOGENOMiHOG000231406
HOVERGENiHBG055078
InParanoidiB1AXD8
OMAiKMAENLC
OrthoDBiEOG091G0PVD
PhylomeDBiB1AXD8
TreeFamiTF317123

Family and domain databases

InterProiView protein in InterPro
IPR024132 Akirin
PANTHERiPTHR13293 PTHR13293, 1 hit

Sequencei

Sequence statusi: Complete.

B1AXD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACGATLKRT LDFDPLLSPA SPKRRRCAPL SAPASAAASP AAATAAAAAS
60 70 80 90 100
AAAASPQKYL RMEPSPFGDV SSRLTTEQIL YNIKQEYKRM QKRRHLEASF
110 120 130 140 150
QQADPGCTSD SQPHAFLISG PASPGTSSAT SSPLKKEQPL FTLRQVGMIC
160 170 180 190 200
ERLLKEREEK VREEYEEILN TKLAEQYDAF VKFTHDQIMR RYGEQPASYV

S
Length:201
Mass (Da):22,113
Last modified:April 8, 2008 - v1
Checksum:i8DB8235D12246DD1
GO

Sequence cautioni

The sequence BAB24265 differs from that shown. Reason: Frameshift at positions 130, 148 and 173.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48A → V in BAB24265 (PubMed:16141072).Curated1
Sequence conflicti181V → G in BAB24265 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005836 mRNA Translation: BAB24265.1 Frameshift.
AL807397 Genomic DNA No translation available.
CCDSiCCDS18027.1
RefSeqiNP_001007590.2, NM_001007589.3
XP_011248362.1, XM_011250060.2
UniGeneiMm.389532
Mm.399624

Genome annotation databases

EnsembliENSMUST00000084299; ENSMUSP00000081322; ENSMUSG00000028291
GeneIDi433693
KEGGimmu:433693
UCSCiuc008sga.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005836 mRNA Translation: BAB24265.1 Frameshift.
AL807397 Genomic DNA No translation available.
CCDSiCCDS18027.1
RefSeqiNP_001007590.2, NM_001007589.3
XP_011248362.1, XM_011250060.2
UniGeneiMm.389532
Mm.399624

3D structure databases

ProteinModelPortaliB1AXD8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi241383, 1 interactor
IntActiB1AXD8, 7 interactors
MINTiB1AXD8
STRINGi10090.ENSMUSP00000081322

PTM databases

iPTMnetiB1AXD8
PhosphoSitePlusiB1AXD8

Proteomic databases

EPDiB1AXD8
MaxQBiB1AXD8
PaxDbiB1AXD8
PeptideAtlasiB1AXD8
PRIDEiB1AXD8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084299; ENSMUSP00000081322; ENSMUSG00000028291
GeneIDi433693
KEGGimmu:433693
UCSCiuc008sga.1 mouse

Organism-specific databases

CTDi55122
MGIiMGI:1889364 Akirin2

Phylogenomic databases

eggNOGiKOG4330 Eukaryota
ENOG4111J00 LUCA
GeneTreeiENSGT00390000007905
HOGENOMiHOG000231406
HOVERGENiHBG055078
InParanoidiB1AXD8
OMAiKMAENLC
OrthoDBiEOG091G0PVD
PhylomeDBiB1AXD8
TreeFamiTF317123

Miscellaneous databases

ChiTaRSiAkirin2 mouse
PROiPR:B1AXD8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028291 Expressed in 291 organ(s), highest expression level in oocyte
GenevisibleiB1AXD8 MM

Family and domain databases

InterProiView protein in InterPro
IPR024132 Akirin
PANTHERiPTHR13293 PTHR13293, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKIR2_MOUSE
AccessioniPrimary (citable) accession number: B1AXD8
Secondary accession number(s): Q641L8, Q9DAH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 8, 2008
Last modified: September 12, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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