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Protein
Submitted name:

Tumor necrosis factor receptor superfamily, member 25

Gene

Tnfrsf25

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily, member 25Imported
Submitted name:
Tumor necrosis factor receptor superfamily, member 25, isoform CRA_bImported
Gene namesi
Name:Tnfrsf25Imported
ORF Names:mCG_4090Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1934667 Tnfrsf25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei197 – 218HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_501508703031 – 411Sequence analysisAdd BLAST381

Expressioni

Gene expression databases

BgeeiENSMUSG00000024793 Expressed in 68 organ(s), highest expression level in brain

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 120TNFR-CysInterPro annotationAdd BLAST44
Repeati77 – 120TNFR-CysPROSITE-ProRule annotationAdd BLAST44
Domaini326 – 407DeathInterPro annotationAdd BLAST82

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000064001
HOVERGENiHBG058493
KOiK05160
OMAiRALHRHT
OrthoDBiEOG091G07LE

Family and domain databases

CDDicd13420 TNFRSF25, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022329 TNFR_25
IPR034050 TNFRSF25_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 1 hit
PRINTSiPR01972 TNFACTORR25
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 2 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B1AWN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARLLRGCV VEPLFLPLLL LLLLLLGGQG QGGMSGRCDC ASESQKRYGP
60 70 80 90 100
FCCRGCPKGH YMKAPCAEPC GNSTCLPCPS DTFLTRDNHF KTDCTRCQVC
110 120 130 140 150
DEEALQVTLE NCSAKSDTHC GCQSGWCVDC STEPCGKSSP FSCVPCGATT
160 170 180 190 200
PVHEAPTPRP CLPGFYIRGN DCTSCPTGFS SVCPKACTAV CGWKQMFWVQ
210 220 230 240 250
VLLGVAFLFG AILICAYCRW QPCKAVVTAD TAGTETLASP QTAHLSASDS
260 270 280 290 300
AHTLLAPPSS TGKICTTVQL VGNNWTPGLS QTQEVVCGQA SQPWDQLPNR
310 320 330 340 350
TLGTPLASPL SPAPPAGSPA AVLQPGPQLY DVMDAVPARR WKEFVRTLGL
360 370 380 390 400
REAEIEAVEV EICRFRDQQY EMLKRWRQQQ PAGLGAIYAA LERMGLEGCA
410
EDLRSRLQRG P
Length:411
Mass (Da):44,264
Last modified:April 8, 2008 - v1
Checksum:i5B3380400BF0964D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8VD70Q8VD70_MOUSE
Tumor necrosis factor receptor supe...
Tnfrsf25 mCG_4090
387Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772240 Genomic DNA No translation available.
CH466594 Genomic DNA Translation: EDL14925.1
RefSeqiNP_001277939.1, NM_001291010.1
UniGeneiMm.101198

Genome annotation databases

EnsembliENSMUST00000025706; ENSMUSP00000025706; ENSMUSG00000024793
GeneIDi85030
KEGGimmu:85030
UCSCiuc056zyo.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772240 Genomic DNA No translation available.
CH466594 Genomic DNA Translation: EDL14925.1
RefSeqiNP_001277939.1, NM_001291010.1
UniGeneiMm.101198

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025706; ENSMUSP00000025706; ENSMUSG00000024793
GeneIDi85030
KEGGimmu:85030
UCSCiuc056zyo.1 mouse

Organism-specific databases

CTDi8718
MGIiMGI:1934667 Tnfrsf25

Phylogenomic databases

GeneTreeiENSGT00530000064001
HOVERGENiHBG058493
KOiK05160
OMAiRALHRHT
OrthoDBiEOG091G07LE

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024793 Expressed in 68 organ(s), highest expression level in brain

Family and domain databases

CDDicd13420 TNFRSF25, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022329 TNFR_25
IPR034050 TNFRSF25_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 1 hit
PRINTSiPR01972 TNFACTORR25
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 2 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1AWN9_MOUSE
AccessioniPrimary (citable) accession number: B1AWN9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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