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Entry version 104 (18 Sep 2019)
Sequence version 1 (08 Apr 2008)
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Protein

Sodium channel protein type 2 subunit alpha

Gene

Scn2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient (PubMed:10827969, PubMed:11166117, PubMed:28137877). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (PubMed:29867081).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1490Important for channel closureBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channel, Voltage-gated channel
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5576892 Phase 0 - rapid depolarisation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel protein type 2 subunit alphaCurated
Alternative name(s):
Voltage-gated sodium channel subunit alpha Nav1.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scn2aImported
Synonyms:Scn2a1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:98248 Scn2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei130 – 148Helical; Name=S1 of repeat IBy similarityAdd BLAST19
Transmembranei156 – 176Helical; Name=S2 of repeat IBy similarityAdd BLAST21
Transmembranei191 – 208Helical; Name=S3 of repeat IBy similarityAdd BLAST18
Transmembranei215 – 231Helical; Name=S4 of repeat IBy similarityAdd BLAST17
Transmembranei251 – 270Helical; Name=S5 of repeat IBy similarityAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei370 – 394Pore-formingBy similarityAdd BLAST25
Transmembranei402 – 422Helical; Name=S6 of repeat IBy similarityAdd BLAST21
Transmembranei761 – 779Helical; Name=S1 of repeat IIBy similarityAdd BLAST19
Transmembranei791 – 810Helical; Name=S2 of repeat IIBy similarityAdd BLAST20
Transmembranei825 – 844Helical; Name=S3 of repeat IIBy similarityAdd BLAST20
Transmembranei847 – 864Helical; Name=S4 of repeat IIBy similarityAdd BLAST18
Transmembranei881 – 899Helical; Name=S5 of repeat IIBy similarityAdd BLAST19
Intramembranei929 – 949Pore-formingBy similarityAdd BLAST21
Transmembranei963 – 983Helical; Name=S6 of repeat IIBy similarityAdd BLAST21
Transmembranei1211 – 1228Helical; Name=S1 of repeat IIIBy similarityAdd BLAST18
Transmembranei1242 – 1260Helical; Name=S2 of repeat IIIBy similarityAdd BLAST19
Transmembranei1275 – 1293Helical; Name=S3 of repeat IIIBy similarityAdd BLAST19
Transmembranei1302 – 1320Helical; Name=S4 of repeat IIIBy similarityAdd BLAST19
Transmembranei1338 – 1357Helical; Name=S5 of repeat IIIBy similarityAdd BLAST20
Intramembranei1410 – 1431Pore-formingBy similarityAdd BLAST22
Transmembranei1449 – 1470Helical; Name=S6 of repeat IIIBy similarityAdd BLAST22
Transmembranei1534 – 1551Helical; Name=S1 of repeat IVBy similarityAdd BLAST18
Transmembranei1563 – 1581Helical; Name=S2 of repeat IVBy similarityAdd BLAST19
Transmembranei1594 – 1611Helical; Name=S3 of repeat IVBy similarityAdd BLAST18
Transmembranei1625 – 1641Helical; Name=S4 of repeat IVBy similarityAdd BLAST17
Transmembranei1661 – 1678Helical; Name=S5 of repeat IVBy similarityAdd BLAST18
Intramembranei1701 – 1723Pore-formingBy similarityAdd BLAST23
Transmembranei1754 – 1776Helical; Name=S6 of repeat IVBy similarityAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Conditional knockout mice deficient in brain are morphologically and organogenically indistinguishable from their heterozygous littermates. They die perinatally with severe hypoxia and massive neuronal apoptosis, notably in the brainstem. Sodium channel currents recorded from cultured neurons of knockout mice are sharply attenuated.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi880 – 882GAL → QQQ: Gain of function mutation. Mutant mice display enhanced persistent sodium current, have seizures and behavioral abnormalities. Half of the mice die before four months of age, and only 10% survive to nine months. Epilepsy severity in this model is strain-dependent. Mutation in a C57BL/6J background exhibit a mild disorder, whereas animals intercrossed with SJL7/j mice show a severe phenotype. 2 Publications3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004466591 – 2006Sodium channel protein type 2 subunit alphaAdd BLAST2006

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi278 ↔ 347By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei468PhosphoserineBy similarity1
Modified residuei471PhosphoserineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei526PhosphoserineBy similarity1
Modified residuei528PhosphoserineBy similarity1
Modified residuei531PhosphoserineBy similarity1
Modified residuei553PhosphoserineBy similarity1
Modified residuei554PhosphoserineBy similarity1
Modified residuei558PhosphoserineBy similarity1
Modified residuei573PhosphoserineBy similarity1
Modified residuei576PhosphoserineBy similarity1
Modified residuei589PhosphoserineBy similarity1
Modified residuei610PhosphoserineBy similarity1
Modified residuei623PhosphoserineBy similarity1
Modified residuei687PhosphoserineBy similarity1
Modified residuei688PhosphoserineBy similarity1
Modified residuei722PhosphoserineBy similarity1
Disulfide bondi911Interchain; with SCN2B or SCN4BBy similarity
Disulfide bondi951 ↔ 960By similarity
Modified residuei1507PhosphoserineBy similarity1
Modified residuei1931PhosphoserineBy similarity1
Modified residuei1944PhosphothreonineBy similarity1
Modified residuei1964PhosphothreonineBy similarity1
Modified residuei1967PhosphothreonineBy similarity1
Modified residuei1972PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated at Lys-38. Sumoylation is induced by hypoxia, increases voltage-gated sodium current and mediates the early response to acute hypoxia in neurons. Sumoylated SCN2A is located at the cell membrane.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B1AWN6

PeptideAtlas

More...
PeptideAtlasi
B1AWN6

PRoteomics IDEntifications database

More...
PRIDEi
B1AWN6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B1AWN6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B1AWN6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain (at protein level) (PubMed:10827969, PubMed:11166117). Detected in hippocampus, cortex and brain stem (PubMed:10827969).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000075318 Expressed in 151 organ(s), highest expression level in piriform cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B1AWN6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterooligomer of a large alpha subunit and a smaller beta subunit. Heterooligomer with SCN2B or SCN4B; disulfide-linked.

Interacts with NEDD4L.

Interacts with CALM.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000028377

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B1AWN6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati111 – 456IBy similarityAdd BLAST346
Repeati742 – 1014IIBy similarityAdd BLAST273
Repeati1191 – 1505IIIBy similarityAdd BLAST315
Repeati1514 – 1812IVBy similarityAdd BLAST299
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1906 – 1935IQPROSITE-ProRule annotationAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INF8 Eukaryota
COG1226 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154224

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231755

KEGG Orthology (KO)

More...
KOi
K04834

Identification of Orthologs from Complete Genome Data

More...
OMAi
ILNKREP

Database of Orthologous Groups

More...
OrthoDBi
56920at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323985

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170 NACHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015 IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

B1AWN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP
60 70 80 90 100
KPNSDLEAGK SLPFIYGDIP PEMVSEPLED LDPYYINKKT FIVLNKGKAI
110 120 130 140 150
SRFSATSALY ILTPFNPIRK LAIKILVHSL FNVLIMCTIL TNCVFMTMSN
160 170 180 190 200
PPDWTKNVEY TFTGIYTFES LIKILARGFC LEDFTFLRDP WNWLDFTVIT
210 220 230 240 250
FAYVTEFVNL GNVSALRTFR VLRALKTISV IPGLKTIVGA LIQSVKKLSD
260 270 280 290 300
VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSTFEI NITSFFNNSL
310 320 330 340 350
DWNGTAFNRT MNMFNWDEYI EDKSHFYFLE GQNDALLCGN SSDAGQCPEG
360 370 380 390 400
YICVKAGRNP NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT
410 420 430 440 450
YMIFFVLVIF LGSFYLINLI LAVVAMAYEE QNQATLEEAE QKEAEFQQML
460 470 480 490 500
EQLKKQQEEA QAAAAAASAE SRDFSGAGGI GVFSESSSVA SKLSSKSEKE
510 520 530 540 550
LKNRRKKKKQ KEQAGEEEKE DAVRKSASED SIRKKGFRFS LEGSRLTYEK
560 570 580 590 600
RFSSPHQSLL SIRGSLFSPR RNSRASLFSF KGRVKDIGSE NDFADDEHST
610 620 630 640 650
FEDNDSRRDS LFVPHRHGER RPSNVSQASR ASRGIPTLPM NGKMHSAVDC
660 670 680 690 700
NGVVSLVGGP SALTSPVGQL LPEGTTTETE IRKRRSSSYH VSMDLLEDPT
710 720 730 740 750
SRQRAMSMAS ILTNTMEELE ESRQKCPPCW YKFANMCLIW DCCKPWLKVK
760 770 780 790 800
HVVNLVVMDP FVDLAITICI VLNTLFMAME HYPMTEQFSS VLSVGNLVFT
810 820 830 840 850
GIFTAEMFLK IIAMDPYYYF QEGWNIFDGF IVSLSLMELG LANVEGLSVL
860 870 880 890 900
RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG
910 920 930 940 950
MQLFGKSYKE CVCKISNDCE LPRWHMHDFF HSFLIVFRVL CGEWIETMWD
960 970 980 990 1000
CMEVAGQTMC LTVFMMVMVI GNLVVLNLFL ALLLSSFSSD NLAATDDDNE
1010 1020 1030 1040 1050
MNNLQIAVGR MQKGIDFVKR KIREFIQKAF VRKQKALDEI KPLEDLNNKK
1060 1070 1080 1090 1100
DSCISNHTTI EIGKDLNYLK DGNGTTSGIG SSVEKYVVDE SDYMSFINNP
1110 1120 1130 1140 1150
SLTVTVPIAV GESDFENLNT EEFSSESDME ESKEKLNATS SSEGSTVDIG
1160 1170 1180 1190 1200
APAEGEQPEA EPEESLEPEA CFTEDCVRKF KCCQISIEEG KGKLWWNLRK
1210 1220 1230 1240 1250
TCYKIVEHNW FETFIVFMIL LSSGALAFED IYIEQRKTIK TMLEYADKVF
1260 1270 1280 1290 1300
TYIFILEMLL KWVAYGFQMY FTNAWCWLDF LIVDVSLVSL TANALGYSEL
1310 1320 1330 1340 1350
GAIKSLRTLR ALRPLRALSR FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL
1360 1370 1380 1390 1400
IFSIMGVNLF AGKFYHCINY TTGEMFDVSV VNNYSECQAL IESNQTARWK
1410 1420 1430 1440 1450
NVKVNFDNVG LGYLSLLQVA TFKGWMDIMY AAVDSRNVEL QPKYEDNLYM
1460 1470 1480 1490 1500
YLYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN
1510 1520 1530 1540 1550
AMKKLGSKKP QKPIPRPANK FQGMVFDFVT KQVFDISIMI LICLNMVTMM
1560 1570 1580 1590 1600
VETDDQSQEM TNILYWINLV FIVLFTGECV LKLISLRHYY FTIGWNIFDF
1610 1620 1630 1640 1650
VVVILSIVGM FLAELIEKYF VSPTLFRVIR LARIGRILRL IKGAKGIRTL
1660 1670 1680 1690 1700
LFALMMSLPA LFNIGLLLFL VMFIYAIFGM SNFAYVKREV GIDDMFNFET
1710 1720 1730 1740 1750
FGNSMICLFQ ITTSAGWDGL LAPILNSGPP DCDPEKDHPG SSVKGDCGNP
1760 1770 1780 1790 1800
SVGIFFFVSY IIISFLVVVN MYIAVILENF SVATEESAEP LSEDDFEMFY
1810 1820 1830 1840 1850
EVWEKFDPDA TQFIEFCKLS DFAAALDPPL LIAKPNKVQL IAMDLPMVSG
1860 1870 1880 1890 1900
DRIHCLDILF AFTKRVLGES GEMDALRIQM EERFMASNPS KVSYEPITTT
1910 1920 1930 1940 1950
LKRKQEEVSA IVIQRAYRRY LLKQKVKKVS SIYKKDKGKE DEGTPIKEDI
1960 1970 1980 1990 2000
ITDKLNENST PEKTDVTPST TSPPSYDSVT KPEKEKFEKD KSEKEDKGKD

IRESKK
Length:2,006
Mass (Da):227,945
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A607C83C4E97F0D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7AMU5F7AMU5_MOUSE
Sodium channel protein type 2 subun...
Scn2a Scn2a1
504Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A9JQD3A9JQD3_MOUSE
Sodium channel Nav1.2
Scn2a Scn2a1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YTX0A0A0J9YTX0_MOUSE
Sodium channel protein type 2 subun...
Scn2a Scn2a1
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti209N → D. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL772235 Genomic DNA No translation available.
BX284648 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38130.1

NCBI Reference Sequences

More...
RefSeqi
NP_001092768.1, NM_001099298.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000028377; ENSMUSP00000028377; ENSMUSG00000075318
ENSMUST00000100067; ENSMUSP00000097645; ENSMUSG00000075318

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
110876

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:110876

UCSC genome browser

More...
UCSCi
uc008jwo.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772235 Genomic DNA No translation available.
BX284648 Genomic DNA No translation available.
CCDSiCCDS38130.1
RefSeqiNP_001092768.1, NM_001099298.3

3D structure databases

SMRiB1AWN6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028377

PTM databases

iPTMnetiB1AWN6
SwissPalmiB1AWN6

Proteomic databases

MaxQBiB1AWN6
PeptideAtlasiB1AWN6
PRIDEiB1AWN6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028377; ENSMUSP00000028377; ENSMUSG00000075318
ENSMUST00000100067; ENSMUSP00000097645; ENSMUSG00000075318
GeneIDi110876
KEGGimmu:110876
UCSCiuc008jwo.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6326
MGIiMGI:98248 Scn2a

Phylogenomic databases

eggNOGiENOG410INF8 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00940000154224
HOGENOMiHOG000231755
KOiK04834
OMAiILNKREP
OrthoDBi56920at2759
TreeFamiTF323985

Enzyme and pathway databases

ReactomeiR-MMU-5576892 Phase 0 - rapid depolarisation

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000075318 Expressed in 151 organ(s), highest expression level in piriform cortex
ExpressionAtlasiB1AWN6 baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR000048 IQ_motif_EF-hand-BS
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
SMARTiView protein in SMART
SM00015 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCN2A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1AWN6
Secondary accession number(s): A0A0J9YTW6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 10, 2019
Last sequence update: April 8, 2008
Last modified: September 18, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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