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Entry version 84 (16 Jan 2019)
Sequence version 1 (08 Apr 2008)
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Protein

Zinc finger protein 462

Gene

Znf462

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (PubMed:17353115). Regulates neuronal development and neural cell differentiation (PubMed:21570965, PubMed:27621227).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri4 – 27C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri108 – 131C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri162 – 185C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri440 – 463C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 616C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri835 – 858C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri878 – 900C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri917 – 940C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1023 – 1046C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1254 – 1277C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1459 – 1482C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1504 – 1527C2H2-type 13PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1566 – 1589C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1649 – 1672C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1686 – 1709C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1881 – 1903C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1957 – 1981C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri2014 – 2037C2H2-type 19PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2043 – 2066C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2072 – 2095C2H2-type 21PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2180 – 2203C2H2-type 22PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2209 – 2232C2H2-type 23PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2243 – 2265C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2289 – 2311C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2317 – 2340C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2403 – 2425C2H2-type 27PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II core promoter sequence-specific DNA binding Source: GO_Central

GO - Biological processi

  • chromatin organization Source: MGI
  • negative regulation of DNA binding Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of gene expression Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 4621 Publication
Alternative name(s):
Zinc finger PBX1-interacting protein1 Publication
Short name:
ZFPIP1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Znf462Curated
Synonyms:Zfp462Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:107690 Zfp462

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethal (PubMed:27621227). Knockout mice do not develop past 18.5 days post coitum and exhibit smaller sized eyes with neural-tube defects (PubMed:27621227). Heterozygous mice exhibit decreased expression and delayed development (PubMed:27621227). Heterozygous mice grow slower, weigh less than wild-type mice and have significantly reduced brain weight (PubMed:27621227). They also exhibit lowered levels of PBX1 and HOXB8 (PubMed:27621227). Mice also exhibit anxiety-like behaviors with excessive grooming, resulting in gradual hair loss (PubMed:27621227).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004456271 – 2495Zinc finger protein 462Add BLAST2495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki234Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki350Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei351PhosphoserineBy similarity1
Modified residuei355PhosphoserineBy similarity1
Cross-linki429Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki485Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki624Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki650Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki661Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei681PhosphoserineBy similarity1
Cross-linki699Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki978Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1083PhosphoserineBy similarity1
Cross-linki1128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1159PhosphoserineBy similarity1
Cross-linki1196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1204Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1232Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1488Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1560Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1580Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1687Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1769Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1935Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1993N6-methyllysineBy similarity1
Cross-linki2093Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei2161PhosphoserineBy similarity1
Modified residuei2166PhosphoserineBy similarity1
Cross-linki2282Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki2493Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B1AWL2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B1AWL2

PeptideAtlas

More...
PeptideAtlasi
B1AWL2

PRoteomics IDEntifications database

More...
PRIDEi
B1AWL2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
B1AWL2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B1AWL2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the cerebral cortex (at protein level) (PubMed:17207666, PubMed:27621227). Expressed in embryonic stem cells (at protein level) (PubMed:20219459). Expressed in heart, liver, kidney, muscle, and female and male genital tracts (at protein level) (PubMed:27621227, PubMed:17353115).4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at 6.5 days post coitum (dpc) in the developing central nervous system (PubMed:17207666). At 7.75 dpc, expression is limited to the headfolds (PubMed:17207666). At 8 dpc, transcripts are detected in the midline neural groove (PubMed:17207666). Between 8 dpc and 9.5 dpc, it is found in the developing forebrain, brainstem, spinal cord, branchial arches, otic vesicles, midbrain and hindbrain folds (PubMed:17207666, PubMed:17353115). At 10.5 dpc, expression is detected in the telencephalic vesicles, branchial arches, otic vesicles, dorsal root ganglia, somites, spinal cord and forelimb buds, specifically in migratory muscle progenitor cells (PubMed:17207666). At 11.5 dpc, it is detected in telencephalic vesicles, midbrain-hindbrain boundary, the spinal cord, branchial arches, dorsal root ganglia, fore- and hindlimb buds and somites (PubMed:17207666, PubMed:17353115). Also detected at 11.5 dpc throughout the wall of the telencephalic vesicle and the medial and lateral ganglionic eminence (PubMed:17353115). At 14.5 dpc, expression is detected in the entire cerebral cortex, with higher levels in the developing hippocampus and septal area (PubMed:17207666). Expression becomes more graded by 16.5 and 18.5 dpc, where it is detected in the caudal and medial cerebral cortex, hippocampus and retrosplenial cortex (PubMed:17207666). Detected at 16.5 dpc in female genital tract (PubMed:17353115). It is also detected in the olfactory bud at 18.5 dpc (PubMed:17207666). Detected at 9.5 dpc in embryos (PubMed:20219459). Detected from 7.5 dpc in the brain, with highest levels of expression being detected at postnatal day 1 (PubMed:27621227). Expression remains at high levels at postnatal day 7 and begins to decrease by postnatal day 14 (PubMed:27621227). Expression is decreased further by postnatal day 30 (PubMed:27621227).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000060206

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
B1AWL2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B1AWL2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PBX1 isoform PBX1b; this interaction prevents PBX1-HOXA9 heterodimer from forming and binding to DNA.1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
B1AWL2, 3 interactors

Molecular INTeraction database

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MINTi
B1AWL2

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000095677

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B1AWL2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni215 – 241Interaction with PBX11 PublicationAdd BLAST27

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 27C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri108 – 131C2H2-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri162 – 185C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri440 – 463C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri471 – 493C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 616C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri835 – 858C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri878 – 900C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri917 – 940C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1023 – 1046C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1254 – 1277C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1459 – 1482C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1504 – 1527C2H2-type 13PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1566 – 1589C2H2-type 14PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1649 – 1672C2H2-type 15PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1686 – 1709C2H2-type 16PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1881 – 1903C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1957 – 1981C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri2014 – 2037C2H2-type 19PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2043 – 2066C2H2-type 20PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2072 – 2095C2H2-type 21PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2180 – 2203C2H2-type 22PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2209 – 2232C2H2-type 23PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2243 – 2265C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2289 – 2311C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri2317 – 2340C2H2-type 26PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri2403 – 2425C2H2-type 27PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156411

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049226

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG058189

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
B1AWL2

Database for complete collections of gene phylogenies

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PhylomeDBi
B1AWL2

TreeFam database of animal gene trees

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TreeFami
TF325534

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 34 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

B1AWL2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVLQCDGCD FRAPSYEDLK AHIQDVHTAF LQPTDVAEDN DDEPLSGSMN
60 70 80 90 100
ASNQTEVEFS SIKDEFVIAE DLPGQSATAL GSGGYYGHSP GYYGQHITPN
110 120 130 140 150
PKPTNKFFQC KFCVRYFRSK NLLIEHTRKV HGAQAEESPT GPPVPGSLNY
160 170 180 190 200
NIMMHEGFGK VFSCQFCTYK SPRRARIIKH QKMYHKNSLK ESTAPPPAPA
210 220 230 240 250
PLPDPLVPPV SLQDPCKELP AEVVERSILE SMVKPLTKSR GNFCCEWCSY
260 270 280 290 300
QTPRRERWCD HMMKKHRSMV KILSSIRQQE GPNVSEAQND NEPSPTSNST
310 320 330 340 350
YLSMNAASRE MPNANVSNFR GSMGNSIMRP NSSSTSKFSS SMSYPQMKPK
360 370 380 390 400
SPHNSGLVNL TERSRYGMSD MTNSSADLDT NSMLNDSSSD EDLNEVDSEN
410 420 430 440 450
GLSVLDHQAS GLSAEQLMGS DGNKLLETKG IPFRRFMNRF QCPFCPFLTM
460 470 480 490 500
HRRSISRHIE NIHLSGKTAV YKCDECPFTC KSSLKLGAHK QCHTGTSDWD
510 520 530 540 550
TVNSQSESLS SSLNEGMVSY ESSSINGRKS GVMLDPLQQQ QPPQPPPPLP
560 570 580 590 600
PPPPPPSQPL PQPPPPPLQS PHQVPPPTQQ PQPPTQAPPL HPYKCTMCSY
610 620 630 640 650
STMTLKGLRV HQQHKHSFCD NLPKFEGQPS SLPLENETDS HPSSSNTVKK
660 670 680 690 700
SQTSILGLSS KNNFVAKANR KLASDFPLDL SPVKKRTRID EIASNLQSKI
710 720 730 740 750
NQTKLQEDAI INVEDDEEEE DDNEVEIEVE LDREEEATDP IMEVPTAFSA
760 770 780 790 800
QQIWARDASE AQKEPNYRSI THDYTATNGA EIELTLSEDE EDYYGSSASM
810 820 830 840 850
KDQVSNAALL NTQPAIYGTE PSNENTDFGD SGRLYYCKHC DFNNKSARSV
860 870 880 890 900
STHYQRMHPY IKFSFRYILD PNDHSAVYRC LECYIDYTNF EDLQQHYGEH
910 920 930 940 950
HPEAMNVLNF DHSDLIYRCR FCSYTSPNVR SLMPHYQRMH PTVKINNAMI
960 970 980 990 1000
FSSYVVEQQE GLNAESQTLR EILNSAPKSM ATSTPVARGG GLPATFNKNT
1010 1020 1030 1040 1050
PPKTFTPECE SQKDPSVNTV VVYDCDVCSF ASPNMHSVLV HYQKKHPEEK
1060 1070 1080 1090 1100
ASYFRIQKTM RMVSVDRGSA LSQLSFEVGA PMSPKMSNMG SPPPPQPPPP
1110 1120 1130 1140 1150
DLSIELYYCK HCSYSNRSVV GVLVHYQKRH PEIKVTAKYI RQAPPTAAMM
1160 1170 1180 1190 1200
RGAEGLQDSP RPPAPLQLNS SERDCPPVET EMFFCQHCDY GNRTVKGVLI
1210 1220 1230 1240 1250
HYQKKHRDFK ANADVIRQHT ATIRSLCDRN QKPASCVLLP ASGMERDKTK
1260 1270 1280 1290 1300
LRALKCRQCS YTSPYFYALR KHIKKDHPAL KATVTSIMRW AFLDGLIEAG
1310 1320 1330 1340 1350
YHCEWCIYSH MEPSGLLLHY QRRHPEHYVD YTYMATKLWA GPDPSSPTLT
1360 1370 1380 1390 1400
MSAEAKTYRC RDCVFEAVSI WDITNHYQAF HPWAMNGDES VLLDIIKEKD
1410 1420 1430 1440 1450
GVDKALLAPE ELIGPVNCEN SIPNPLPEQE AECPEDARLS PEKSIHLASA
1460 1470 1480 1490 1500
NPAISSTPYQ CTVCQSEYNN LHGLLTHYGK KHPGMKVKAA DFAQDIDINP
1510 1520 1530 1540 1550
GAVYKCRHCP YINTRIHGVL THYQKRHPAI KVTAEDFVHD VEQSADISQN
1560 1570 1580 1590 1600
DVEETSRIFK QGYGAYRCKL CPYTHGTLEK LKIHYEKYHN QPEFDVFSPP
1610 1620 1630 1640 1650
PPKLPVSLEP EITTEVSPSQ VSVTEEEVGE DPMSTAHFST SHLVSHTVFR
1660 1670 1680 1690 1700
CQLCKYFCST RKGIARHYRI KHNNVRAQPE GKNNLFKCAL CAYTNPIRKG
1710 1720 1730 1740 1750
LAAHYQKRHD IDAYYTHCLA ASRTISDKPN KVIIPSPPKD DSPQLSEELR
1760 1770 1780 1790 1800
RAVEKKKCSL CSFQSFSKKG IVSHYMKRHP GVFPKKQHAS KLGGYFTAVY
1810 1820 1830 1840 1850
ADEHEKPPLM EEEERSSFER AEVEGEAQDI EWLPFRCIKC FKLSFSTAEL
1860 1870 1880 1890 1900
LCMHYTDHHS RDLKRDFVIL GSGPRFQNST FQCKHCDSKL QSIAELTSHL
1910 1920 1930 1940 1950
NIHNEEFQKR AKRQERRKQL LSKQKYADGA FADFKQERPF GHLEEVPKIK
1960 1970 1980 1990 2000
ERKVVGYKCK FCVEVHPTLR AICNHLRKHV QYGSVPAVSA AVKGLRSHER
2010 2020 2030 2040 2050
SHLALAMFTR EDKYSCQYCS FVSAFRHNLD RHMQTHHGHH KPFRCKLCSF
2060 2070 2080 2090 2100
KSSYNSRLKT HILKAHAGEH AYKCSWCSFS TMTISQLKEH SLKVHGKALT
2110 2120 2130 2140 2150
LPRPRIVSLL SSHAHPSSQK ATPAEEVEDS NDSSYSEPPD VQQQLNHYQS
2160 2170 2180 2190 2200
AALARNKSRV SPVPPSGTAA GTEQKAEAVL HCEFCEFSSG YIQSIRRHYR
2210 2220 2230 2240 2250
DKHGGKKLFK CKDCSFYTGF KSAFTMHVEA GHSAVPEEGP KDLRCPLCLY
2260 2270 2280 2290 2300
HTKYKRNMID HIVLHREERV VPIEVCRSKL SKYLQGVVFR CDKCTFTCSS
2310 2320 2330 2340 2350
DESLQQHIEK HNELKPYKCQ LCYYETKHTE ELDTHLRDEH KVSRNFELVG
2360 2370 2380 2390 2400
RVNLDQLEQM KEKIESSSSE DEDKDDEMSS KAEDRELMRF ADRGPGVNTE
2410 2420 2430 2440 2450
KRFPCEFCGR AFSQGSEWER HVLRHGMSLH DTNQVSRNEI HTKEMVEESM
2460 2470 2480 2490
QLPSIEAKED DEPIGIDFPL KSETVTICVV AADKSLLEDA EAKNE
Length:2,495
Mass (Da):282,713
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5291910B790FDA8C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AWL5B1AWL5_MOUSE
Zinc finger protein 462
Zfp462
1,408Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AWL4B1AWL4_MOUSE
Zinc finger protein 462
Zfp462
1,407Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AWL3B1AWL3_MOUSE
Zinc finger protein 462
Zfp462
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti167C → R in ABC79685 (PubMed:17207666).Curated1
Sequence conflicti287A → V in ABC79685 (PubMed:17207666).Curated1
Sequence conflicti561P → Q in ABC79685 (PubMed:17207666).Curated1
Sequence conflicti574V → VPPQPQ in ABC79685 (PubMed:17207666).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ355518 mRNA Translation: ABC79685.1
AL772186 Genomic DNA No translation available.
AL844140 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38764.1

NCBI Reference Sequences

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RefSeqi
NP_766455.2, NM_172867.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.102904

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000098070; ENSMUSP00000095677; ENSMUSG00000060206

Database of genes from NCBI RefSeq genomes

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GeneIDi
242466

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:242466

UCSC genome browser

More...
UCSCi
uc008sxi.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ355518 mRNA Translation: ABC79685.1
AL772186 Genomic DNA No translation available.
AL844140 Genomic DNA No translation available.
CCDSiCCDS38764.1
RefSeqiNP_766455.2, NM_172867.3
UniGeneiMm.102904

3D structure databases

ProteinModelPortaliB1AWL2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB1AWL2, 3 interactors
MINTiB1AWL2
STRINGi10090.ENSMUSP00000095677

PTM databases

iPTMnetiB1AWL2
PhosphoSitePlusiB1AWL2

Proteomic databases

MaxQBiB1AWL2
PaxDbiB1AWL2
PeptideAtlasiB1AWL2
PRIDEiB1AWL2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098070; ENSMUSP00000095677; ENSMUSG00000060206
GeneIDi242466
KEGGimmu:242466
UCSCiuc008sxi.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
242466
MGIiMGI:107690 Zfp462

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000156411
HOGENOMiHOG000049226
HOVERGENiHBG058189
InParanoidiB1AWL2
PhylomeDBiB1AWL2
TreeFamiTF325534

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Zfp462 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000060206
ExpressionAtlasiB1AWL2 baseline and differential
GenevisibleiB1AWL2 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 34 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN462_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1AWL2
Secondary accession number(s): A2SW42
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2018
Last sequence update: April 8, 2008
Last modified: January 16, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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