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Protein

Transmembrane protein 8B

Gene

Tmem8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 8B
Alternative name(s):
Protein NGX6
Gene namesi
Name:Tmem8b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2441680 Tmem8b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 233ExtracellularSequence analysisAdd BLAST233
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 257CytoplasmicSequence analysis3
Transmembranei258 – 277HelicalSequence analysisAdd BLAST20
Topological domaini278 – 292ExtracellularSequence analysisAdd BLAST15
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 315CytoplasmicSequence analysis2
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 342ExtracellularSequence analysis6
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 379CytoplasmicSequence analysisAdd BLAST16
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 405ExtracellularSequence analysis5
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 472CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330401 – 472Transmembrane protein 8BAdd BLAST472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi186 ↔ 196By similarity
Disulfide bondi190 ↔ 209By similarity
Disulfide bondi211 ↔ 220By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiB1AWJ5
PRIDEiB1AWJ5

PTM databases

iPTMnetiB1AWJ5
PhosphoSitePlusiB1AWJ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000078716 Expressed in 208 organ(s), highest expression level in brain
ExpressionAtlasiB1AWJ5 baseline and differential
GenevisibleiB1AWJ5 MM

Interactioni

Subunit structurei

May interact with EZR.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103496

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 221EGF-likeAdd BLAST40

Sequence similaritiesi

Belongs to the TMEM8 family.Curated

Keywords - Domaini

EGF-like domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJ3 Eukaryota
ENOG4111FA8 LUCA
GeneTreeiENSGT00390000004668
HOGENOMiHOG000049225
InParanoidiB1AWJ5
PhylomeDBiB1AWJ5
TreeFamiTF331003

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR021910 NGX6/PGAP6/MYMK
PANTHERiPTHR14319 PTHR14319, 1 hit
PfamiView protein in Pfam
PF12036 DUF3522, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

B1AWJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMPQSLGTQ PLPPEPPSLG TPIEGSGAIA PTEHCWPVRP TLRNELDTFS
60 70 80 90 100
VHFYIFFGPS VALPPERPAV FALRLLPVLD SGGVLSLELQ LNASSLRQEN
110 120 130 140 150
VTVFGCLTHE VPLSLGDAAV TCSKESLAGF LLSVSATSRV ARLRIPFPQT
160 170 180 190 200
GTWFLTLRSL CGVGPRFVRC RNATAEVRLR TFLSPCVDDC GPYGQCKLLR
210 220 230 240 250
THNYLYAACE CKAGWRGWGC TDSADALTYG FQLLSTLLLC LSNLMFLPPV
260 270 280 290 300
VLAIRSRYVL EAAVYTFTMF FSTFYHACDQ PGIVVFCIMD YDVLQFCDFL
310 320 330 340 350
GSLMSVWVTV IAMARLQPVI KQVLYLLGAM LLSMALQLDR HGLWNLLGPS
360 370 380 390 400
LFALGILATA WTVRSVRRRH CYPPTWRRWL FYLCPGSLIA GSAVLLYAFV
410 420 430 440 450
ETRDNYFYIH SIWHMLIAGS VGFLLPPRAK TDRRVPSGAR ARGCGYQLCI
460 470
NEQEELGLVG PGGTTVSSIC VS
Length:472
Mass (Da):52,114
Last modified:April 8, 2008 - v1
Checksum:i7CA09DD6D1676DDE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AWJ4B1AWJ4_MOUSE
Transmembrane protein 8B
Tmem8b
931Annotation score:
E9Q7V8E9Q7V8_MOUSE
Transmembrane protein 8B
Tmem8b
154Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732626 Genomic DNA No translation available.
BC147569 mRNA Translation: AAI47570.1
BC147574 mRNA Translation: AAI47575.1
BC151067 mRNA Translation: AAI51068.1
BC151070 mRNA Translation: AAI51071.1
CCDSiCCDS51168.1
RefSeqiNP_001078977.1, NM_001085508.2
XP_011248332.1, XM_011250030.2
UniGeneiMm.171489

Genome annotation databases

EnsembliENSMUST00000107864; ENSMUSP00000103496; ENSMUSG00000078716
ENSMUST00000107865; ENSMUSP00000103497; ENSMUSG00000078716
ENSMUST00000167153; ENSMUSP00000129760; ENSMUSG00000078716
GeneIDi242409
KEGGimmu:242409
UCSCiuc008sqv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732626 Genomic DNA No translation available.
BC147569 mRNA Translation: AAI47570.1
BC147574 mRNA Translation: AAI47575.1
BC151067 mRNA Translation: AAI51068.1
BC151070 mRNA Translation: AAI51071.1
CCDSiCCDS51168.1
RefSeqiNP_001078977.1, NM_001085508.2
XP_011248332.1, XM_011250030.2
UniGeneiMm.171489

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103496

PTM databases

iPTMnetiB1AWJ5
PhosphoSitePlusiB1AWJ5

Proteomic databases

PaxDbiB1AWJ5
PRIDEiB1AWJ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107864; ENSMUSP00000103496; ENSMUSG00000078716
ENSMUST00000107865; ENSMUSP00000103497; ENSMUSG00000078716
ENSMUST00000167153; ENSMUSP00000129760; ENSMUSG00000078716
GeneIDi242409
KEGGimmu:242409
UCSCiuc008sqv.1 mouse

Organism-specific databases

CTDi51754
MGIiMGI:2441680 Tmem8b

Phylogenomic databases

eggNOGiENOG410IHJ3 Eukaryota
ENOG4111FA8 LUCA
GeneTreeiENSGT00390000004668
HOGENOMiHOG000049225
InParanoidiB1AWJ5
PhylomeDBiB1AWJ5
TreeFamiTF331003

Miscellaneous databases

PROiPR:B1AWJ5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078716 Expressed in 208 organ(s), highest expression level in brain
ExpressionAtlasiB1AWJ5 baseline and differential
GenevisibleiB1AWJ5 MM

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR021910 NGX6/PGAP6/MYMK
PANTHERiPTHR14319 PTHR14319, 1 hit
PfamiView protein in Pfam
PF12036 DUF3522, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM8B_MOUSE
AccessioniPrimary (citable) accession number: B1AWJ5
Secondary accession number(s): B9EJV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: September 12, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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