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Protein

Phosphodiesterase

Gene

Pde4b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation

GO - Molecular functioni

  • 3',5'-cyclic-AMP phosphodiesterase activity Source: MGI
  • cAMP binding Source: MGI
  • gamma-tubulin binding Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-180024 DARPP-32 events
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:Pde4bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99557 Pde4b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

MaxQBiB1AWC8
PeptideAtlasiB1AWC8
PRIDEiB1AWC8

Expressioni

Gene expression databases

BgeeiENSMUSG00000028525 Expressed in 275 organ(s), highest expression level in left lung lobe
ExpressionAtlasiB1AWC8 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB1AWC8
SMRiB1AWC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini253 – 582PDEaseInterPro annotationAdd BLAST330

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00760000118889
HOGENOMiHOG000236297
HOVERGENiHBG108239

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

B1AWC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHVNDLPPP RRHSWICFDV ENGPSPGRSP LDPQAGSSSG LVLHAAFPGH
60 70 80 90 100
SQRRESFLYR SDSDYDLSPK AMSRNSSLPS EQHGDDLIVT PFAQVLASLR
110 120 130 140 150
SVRNNFTLLT NLHGAPNKRS PAASQAPVSR VSLQEESYQK LAMETLEELD
160 170 180 190 200
WCLDQLETIQ TYRSVSEMAS NKFKRMLNRE LTHLSEMSRS GNQVSEYISN
210 220 230 240 250
TFLDKQNDVE IPSPTQKDRE KKKKQQLMTQ ISGVKKLMHS SSLNNTSISR
260 270 280 290 300
FGVNTENEDH LAKELEDLNK WGLNIFNVAG YSHNRPLTCI MYAIFQERDL
310 320 330 340 350
LKTFKISSDT FVTYMMTLED HYHSDVAYHN SLHAADVAQS THVLLSTPAL
360 370 380 390 400
DAVFTDLEIL AAIFAAAIHD VDHPGVSNQF LINTNSELAL MYNDESVLEN
410 420 430 440 450
HHLAVGFKLL QEEHCDIFQN LTKKQRQTLR KMVIDMVLAT DMSKHMSLLA
460 470 480 490 500
DLKTMVETKK VTSSGVLLLD NYTDRIQVLR NMVHCADLSN PTKSLELYRQ
510 520 530 540 550
WTDRIMEEFF QQGDKERERG MEISPMCDKH TASVEKSQVG FIDYIVHPLW
560 570 580 590 600
ETWADLVQPD AQDILDTLED NRNWYQSMIP QSPSPPLDER SRDCQGLMEK
610 620 630 640 650
FQFELTLEEE DSEGPEKEGE GHSYFSSTKT LCVIDPENRD SLEETDIDIA

TEDKSPIDT
Length:659
Mass (Da):75,012
Last modified:April 8, 2008 - v1
Checksum:iA0E6B04C22AB9714
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AWC9B1AWC9_MOUSE
Phosphodiesterase
Pde4b
736Annotation score:
B1AWD0B1AWD0_MOUSE
Phosphodiesterase
Pde4b
564Annotation score:
Q8VBU5Q8VBU5_MOUSE
Phosphodiesterase
Pde4b mCG_113038
721Annotation score:
Q6IQY6Q6IQY6_MOUSE
Phosphodiesterase
Pde4b
503Annotation score:
Q3TTI9Q3TTI9_MOUSE
Phosphodiesterase
Pde4b
484Annotation score:
B1AWD1B1AWD1_MOUSE
Phosphodiesterase 4B, cAMP-specific
Pde4b
402Annotation score:
Q80VK8Q80VK8_MOUSE
Pde4b protein
Pde4b
212Annotation score:
G3UWT3G3UWT3_MOUSE
Phosphodiesterase 4B, cAMP-specific
Pde4b
166Annotation score:
G3UZ46G3UZ46_MOUSE
Phosphodiesterase 4B, cAMP-specific
Pde4b
161Annotation score:
G3UZY9G3UZY9_MOUSE
Phosphodiesterase 4B, cAMP-specific
Pde4b
121Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732551 Genomic DNA No translation available.
AL772293 Genomic DNA No translation available.
AL772358 Genomic DNA No translation available.
AL807794 Genomic DNA No translation available.
RefSeqiXP_006502920.1, XM_006502857.3
UniGeneiMm.20181

Genome annotation databases

EnsembliENSMUST00000106904; ENSMUSP00000102517; ENSMUSG00000028525
GeneIDi18578

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732551 Genomic DNA No translation available.
AL772293 Genomic DNA No translation available.
AL772358 Genomic DNA No translation available.
AL807794 Genomic DNA No translation available.
RefSeqiXP_006502920.1, XM_006502857.3
UniGeneiMm.20181

3D structure databases

ProteinModelPortaliB1AWC8
SMRiB1AWC8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiB1AWC8
PeptideAtlasiB1AWC8
PRIDEiB1AWC8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106904; ENSMUSP00000102517; ENSMUSG00000028525
GeneIDi18578

Organism-specific databases

CTDi5142
MGIiMGI:99557 Pde4b

Phylogenomic databases

eggNOGiKOG3689 Eukaryota
ENOG410XRI7 LUCA
GeneTreeiENSGT00760000118889
HOGENOMiHOG000236297
HOVERGENiHBG108239

Enzyme and pathway databases

ReactomeiR-MMU-180024 DARPP-32 events
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

ChiTaRSiPde4b mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028525 Expressed in 275 organ(s), highest expression level in left lung lobe
ExpressionAtlasiB1AWC8 baseline and differential

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.10, 1 hit
InterProiView protein in InterPro
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1AWC8_MOUSE
AccessioniPrimary (citable) accession number: B1AWC8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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