UniProtKB - B1AVZ0 (UPP_MOUSE)
Protein
Uracil phosphoribosyltransferase homolog
Gene
Uprt
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
The uracil binding region known from UPRTases is missing.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 134 | GTPBy similarity | 1 | |
Binding sitei | 143 | GTPBy similarity | 1 | |
Binding sitei | 187 | 5-phospho-alpha-D-ribose 1-diphosphateBy similarity | 1 | |
Binding sitei | 204 | GTPBy similarity | 1 | |
Binding sitei | 233 | GTPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 177 – 180 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-KW
- kinase activity Source: GO_Central
GO - Biological processi
- female pregnancy Source: Ensembl
- lactation Source: Ensembl
- nucleoside metabolic process Source: InterPro
- response to insulin Source: Ensembl
- UMP biosynthetic process Source: MGI
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Uracil phosphoribosyltransferase homolog |
Gene namesi | Name:Uprt |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685620, Uprt |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleoplasm Source: MGI
Other locations
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000413215 | 1 – 310 | Uracil phosphoribosyltransferase homologAdd BLAST | 310 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | B1AVZ0 |
jPOSTi | B1AVZ0 |
MaxQBi | B1AVZ0 |
PaxDbi | B1AVZ0 |
PeptideAtlasi | B1AVZ0 |
PRIDEi | B1AVZ0 |
PTM databases
iPTMneti | B1AVZ0 |
PhosphoSitePlusi | B1AVZ0 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000073016, Expressed in forelimb bud and 50 other tissues |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000085175 |
Miscellaneous databases
RNActi | B1AVZ0, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 239 – 247 | 5-phospho-alpha-D-ribose 1-diphosphate bindingBy similarity | 9 | |
Regioni | 300 – 302 | Uracil bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the UPRTase family.Curated
Phylogenomic databases
eggNOGi | KOG1017, Eukaryota |
GeneTreei | ENSGT01010000222379 |
HOGENOMi | CLU_067096_1_0_1 |
InParanoidi | B1AVZ0 |
OMAi | NLFCTPM |
OrthoDBi | 929897at2759 |
PhylomeDBi | B1AVZ0 |
TreeFami | TF105900 |
Family and domain databases
CDDi | cd06223, PRTases_typeI, 1 hit |
Gene3Di | 3.40.50.2020, 1 hit |
InterProi | View protein in InterPro IPR000836, PRibTrfase_dom IPR029057, PRTase-like |
SUPFAMi | SSF53271, SSF53271, 1 hit |
i Sequence
Sequence statusi: Complete.
B1AVZ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASELQRPDS MPCHNRQVNS TSSPSPEHLL AEDRVLDHAE ENNAAMAKLT
60 70 80 90 100
LLPGHAHSSV LSERDSPACC STNLHSENHS DSSDSGNYDA PVGGDSLLGD
110 120 130 140 150
CELSRQIGAQ LKLLPMNDQI RELQTIIRDK TASRGDFMFS ADRLIRLVVE
160 170 180 190 200
EGLNQLPYKE CMVTTPTGHK YEGVKFEKGN CGVSIMRSGE AMEQGLRDCC
210 220 230 240 250
RSIRIGKILI QSDEETQRAK VYYAKFPPDI HRRKVLLMYP ILSTGNTVIE
260 270 280 290 300
AVKVLIEHGV QPSVIILLSL FSTPHGAKSI IQEFPEITIL TTEVHPVAPT
310
HFGQKYFGTD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL731717 Genomic DNA No translation available. BC147845 mRNA Translation: AAI47846.1 BC147853 mRNA Translation: AAI47854.1 |
CCDSi | CCDS41093.1 |
RefSeqi | NP_001074658.1, NM_001081189.1 |
Genome annotation databases
Ensembli | ENSMUST00000087867; ENSMUSP00000085175; ENSMUSG00000073016 |
GeneIDi | 331487 |
KEGGi | mmu:331487 |
UCSCi | uc009uai.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL731717 Genomic DNA No translation available. BC147845 mRNA Translation: AAI47846.1 BC147853 mRNA Translation: AAI47854.1 |
CCDSi | CCDS41093.1 |
RefSeqi | NP_001074658.1, NM_001081189.1 |
3D structure databases
SMRi | B1AVZ0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000085175 |
PTM databases
iPTMneti | B1AVZ0 |
PhosphoSitePlusi | B1AVZ0 |
Proteomic databases
EPDi | B1AVZ0 |
jPOSTi | B1AVZ0 |
MaxQBi | B1AVZ0 |
PaxDbi | B1AVZ0 |
PeptideAtlasi | B1AVZ0 |
PRIDEi | B1AVZ0 |
Protocols and materials databases
Antibodypediai | 361, 256 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000087867; ENSMUSP00000085175; ENSMUSG00000073016 |
GeneIDi | 331487 |
KEGGi | mmu:331487 |
UCSCi | uc009uai.1, mouse |
Organism-specific databases
CTDi | 139596 |
MGIi | MGI:2685620, Uprt |
Phylogenomic databases
eggNOGi | KOG1017, Eukaryota |
GeneTreei | ENSGT01010000222379 |
HOGENOMi | CLU_067096_1_0_1 |
InParanoidi | B1AVZ0 |
OMAi | NLFCTPM |
OrthoDBi | 929897at2759 |
PhylomeDBi | B1AVZ0 |
TreeFami | TF105900 |
Miscellaneous databases
BioGRID-ORCSi | 331487, 1 hit in 17 CRISPR screens |
PROi | PR:B1AVZ0 |
RNActi | B1AVZ0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000073016, Expressed in forelimb bud and 50 other tissues |
Family and domain databases
CDDi | cd06223, PRTases_typeI, 1 hit |
Gene3Di | 3.40.50.2020, 1 hit |
InterProi | View protein in InterPro IPR000836, PRibTrfase_dom IPR029057, PRTase-like |
SUPFAMi | SSF53271, SSF53271, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UPP_MOUSE | |
Accessioni | B1AVZ0Primary (citable) accession number: B1AVZ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2011 |
Last sequence update: | April 8, 2008 | |
Last modified: | December 2, 2020 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families