Kinesin-like protein KIF16B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• ATP hydrolysis activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• microtubule binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• microtubule motor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
• phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
• phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
• phosphatidylinositol-3-phosphate binding Source: UniProtKB
• plus-end-directed microtubule motor activity Source: UniProtKB
• small GTPase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.7

    "KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor."
    Ueno H., Huang X., Tanaka Y., Hirokawa N.
    Dev. Cell 20:60-71(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH RAB14.

GO - Biological processⁱ

• cellular response to interferon-gamma Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.5

    "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
• early endosome to late endosome transport Source: UniProtKB
• endoderm development Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.7

    "KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor."
    Ueno H., Huang X., Tanaka Y., Hirokawa N.
    Dev. Cell 20:60-71(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH RAB14.
• epidermal growth factor receptor signaling pathway Source: UniProtKB
• fibroblast growth factor receptor signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.7

    "KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor."
    Ueno H., Huang X., Tanaka Y., Hirokawa N.
    Dev. Cell 20:60-71(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH RAB14.
• formation of primary germ layer Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.7

    "KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor."
    Ueno H., Huang X., Tanaka Y., Hirokawa N.
    Dev. Cell 20:60-71(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH RAB14.
• Golgi to endosome transport Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.7

    "KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor."
    Ueno H., Huang X., Tanaka Y., Hirokawa N.
    Dev. Cell 20:60-71(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH RAB14.
• microtubule-based movement Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• receptor catabolic process Source: UniProtKB
• regulation of receptor recycling Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• microtubule binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• small GTPase binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.7

    "KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor."
    Ueno H., Huang X., Tanaka Y., Hirokawa N.
    Dev. Cell 20:60-71(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH RAB14.

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MASVKVAVRV RPMNRREKDL EAKFIIQMEK SKTTITNLKI PEGGTGDSGR 
        60         70         80         90        100
ERTKTFTYDF SFYSADTKSP DYVSQEMVFK TLGTDVVKSA FEGYNACVFA 
       110        120        130        140        150
YGQTGSGKSY TMMGNSGDSG LIPRICEALF SRINETTRWD EASFRTEVSY 
       160        170        180        190        200
LEIYNERVRD LLRRKSSKTF NLRVREHPKE GPYVEDLSKH LVQNYSDVEE 
       210        220        230        240        250
LMDAGNINRT TAATGMNDVS SRSHAIFTIK FTQAKFDAEM PCETVSKIHL 
       260        270        280        290        300
VDLAGSERAD ATGATGVRLK EGGNINKSLV TLGNVISALA DLSQDAANPL 
       310        320        330        340        350
VKKKQVFVPY RDSVLTWLLK DSLGGNSKTI MIATISPADV NYGETLSTLR 
       360        370        380        390        400
YANRAKNIIN KPTINEDANV KLIRELRAEI ARLKTLLAQG NQIALLDSPT 
       410        420        430        440        450
ALSMEEKLHQ NEARVQELTK EWTNKWNETQ NILKEQTLAL RKEGIGVVLD 
       460        470        480        490        500
SELPHLIGID DDLLSTGIIL YHLKEGQTYV GREDASTEQD IVLHGLDLES 
       510        520        530        540        550
EHCVFENAGG TVTLIPLRGS QCSVNGVQIV DATQLNQGAV ILLGRTNMFR 
       560        570        580        590        600
FNHPKEAAKL REKRKSGLLS SFSLSMTDLS KSCENLSAVM LYNPGLEFER 
       610        620        630        640        650
QQREELEKLE SKRKLIEEME EKQKSDKAEL ERMQQEVETR RKETEIVQRQ 
       660        670        680        690        700
IRKQEESLKR RSFHIENKLK DLLAEKERFE EERLREQQGL EQQRRQEEES 
       710        720        730        740        750
LFRIREELRK LQELNSHEQA EKVQIFQELD RLHQEQNAQS AKLRLEKRRL 
       760        770        780        790        800
EEEEKEQVQR VAHLEEQLRK RQDTAPLLCP GEAQRAQEEK RELESIREAL 
       810        820        830        840        850
LQAKEMRAGG DHTCRDELER AQQYFLEFKR RQLVKLASLE KDLVQQKDLL 
       860        870        880        890        900
SKEVQEEKVA LEHVKCDAGG DPSFLATDDG NILGGPPDLD KIKTAETRLQ 
       910        920        930        940        950
SREHQLQDLL QNHLPALLEE KQRVLDALDS GVLGLDTTLC QVEKEVGEKE 
       960        970        980        990       1000
EQIAQYQANA SQLQQLRATF EFTANVARQE EKVRRKEKEI LESQEKQQRE 
      1010       1020       1030       1040       1050
ALEQAVAKLE QRRSALQRCS TLDLEIQEQR QKLGSLHTSE WSGWQASLET 
      1060       1070       1080       1090       1100
DGEALEMDPA RLEHEIHQLK QKICEVDGVQ RPHHGILEGQ AVLSSLPPSG 
      1110       1120       1130       1140       1150
GNSHLAPLMD ARISAYIEEE VQRRLHDLHR AIGDANHTPA DVMKSNEELH 
      1160       1170       1180       1190       1200
NGTTQRKLKY ERMYSRSLGT NRDDLKDPIK ISIPRYVLCG QGKDEHFEFE 
      1210       1220       1230       1240       1250
VKISVLDETW TVFRRYSRFR EMHKTLKLKY AELAALEFPP KKLFGNKDER 
      1260       1270       1280       1290       1300
VVAERRTHLE KYLREFFSVM LQSETSPLHI NKVGLTLSKH TICEFSPFFK 
      1310 
KGVFDYSSHG TG                                          

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families