UniProtKB - B1AVY7 (KI16B_MOUSE)
Kinesin-like protein KIF16B
Kif16b
Functioni
Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 102 – 109 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: GO_Central
- microtubule binding Source: GO_Central
- microtubule motor activity Source: GO_Central
- phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
- phosphatidylinositol-3,4-bisphosphate binding Source: UniProtKB
- phosphatidylinositol-3,5-bisphosphate binding Source: UniProtKB
- phosphatidylinositol-3-phosphate binding Source: UniProtKB
- plus-end-directed microtubule motor activity Source: UniProtKB
- small GTPase binding Source: UniProtKB
GO - Biological processi
- cellular response to interferon-gamma Source: MGI
- early endosome to late endosome transport Source: UniProtKB
- endoderm development Source: UniProtKB
- epidermal growth factor receptor signaling pathway Source: UniProtKB
- fibroblast growth factor receptor signaling pathway Source: UniProtKB
- formation of primary germ layer Source: UniProtKB
- Golgi to endosome transport Source: UniProtKB
- microtubule-based movement Source: GO_Central
- receptor catabolic process Source: UniProtKB
- regulation of receptor recycling Source: UniProtKB
Keywordsi
Molecular function | Motor protein |
Biological process | Transport |
Ligand | ATP-binding, Lipid-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189, Kinesins |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIF16B |
Gene namesi | Name:Kif16b Synonyms:Kiaa1590 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1098240, Kif16b |
VEuPathDBi | HostDB:ENSMUSG00000038844 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Endosome
- Early endosome membrane By similarity
Cytoskeleton
- cytoskeleton By similarity
- spindle By similarity
Note: It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns3P)-binding or via its interaction with RAB14.By similarity
Cytoskeleton
- kinesin complex Source: GO_Central
- microtubule Source: GO_Central
- spindle Source: MGI
Cytosol
- cytosol Source: GOC
Endosome
- early endosome Source: UniProtKB
- early endosome membrane Source: UniProtKB-SubCell
- endosome Source: UniProtKB
Other locations
- cytoplasm Source: MGI
- phagocytic vesicle Source: MGI
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Endosome, Membrane, MicrotubulePathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000409500 | 1 – 1312 | Kinesin-like protein KIF16BAdd BLAST | 1312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 398 | PhosphoserineBy similarity | 1 | |
Modified residuei | 577 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 582 | PhosphoserineCombined sources | 1 | |
Modified residuei | 838 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1047 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1145 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | B1AVY7 |
MaxQBi | B1AVY7 |
PaxDbi | B1AVY7 |
PeptideAtlasi | B1AVY7 |
PRIDEi | B1AVY7 |
ProteomicsDBi | 263599 |
PTM databases
iPTMneti | B1AVY7 |
PhosphoSitePlusi | B1AVY7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000038844, Expressed in submandibular gland and 306 other tissues |
ExpressionAtlasi | B1AVY7, baseline and differential |
Genevisiblei | B1AVY7, MM |
Interactioni
Subunit structurei
Interacts with PTPN21 (By similarity).
Interacts with RAB14.
By similarity1 PublicationGO - Molecular functioni
- microtubule binding Source: GO_Central
- small GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 200933, 3 interactors |
STRINGi | 10090.ENSMUSP00000042551 |
Miscellaneous databases
RNActi | B1AVY7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 358 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 356 | |
Domaini | ?480 – ?544 | FHAAdd BLAST | 65 | |
Domaini | 1177 – 1291 | PXPROSITE-ProRule annotationAdd BLAST | 115 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 366 – 425 | Sequence analysisAdd BLAST | 60 | |
Coiled coili | 835 – 913 | Sequence analysisAdd BLAST | 79 | |
Coiled coili | 941 – 1073 | Sequence analysisAdd BLAST | 133 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0245, Eukaryota KOG2101, Eukaryota |
GeneTreei | ENSGT00940000162977 |
HOGENOMi | CLU_001485_35_0_1 |
InParanoidi | B1AVY7 |
OMAi | THHEFEV |
OrthoDBi | 76316at2759 |
PhylomeDBi | B1AVY7 |
TreeFami | TF105221 |
Family and domain databases
Gene3Di | 3.30.1520.10, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase IPR001683, PX_dom IPR036871, PX_dom_sf IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00498, FHA, 1 hit PF00225, Kinesin, 1 hit PF00787, PX, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit SM00312, PX, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF52540, SSF52540, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit PS50195, PX, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MASVKVAVRV RPMNRREKDL EAKFIIQMEK SKTTITNLKI PEGGTGDSGR
60 70 80 90 100
ERTKTFTYDF SFYSADTKSP DYVSQEMVFK TLGTDVVKSA FEGYNACVFA
110 120 130 140 150
YGQTGSGKSY TMMGNSGDSG LIPRICEALF SRINETTRWD EASFRTEVSY
160 170 180 190 200
LEIYNERVRD LLRRKSSKTF NLRVREHPKE GPYVEDLSKH LVQNYSDVEE
210 220 230 240 250
LMDAGNINRT TAATGMNDVS SRSHAIFTIK FTQAKFDAEM PCETVSKIHL
260 270 280 290 300
VDLAGSERAD ATGATGVRLK EGGNINKSLV TLGNVISALA DLSQDAANPL
310 320 330 340 350
VKKKQVFVPY RDSVLTWLLK DSLGGNSKTI MIATISPADV NYGETLSTLR
360 370 380 390 400
YANRAKNIIN KPTINEDANV KLIRELRAEI ARLKTLLAQG NQIALLDSPT
410 420 430 440 450
ALSMEEKLHQ NEARVQELTK EWTNKWNETQ NILKEQTLAL RKEGIGVVLD
460 470 480 490 500
SELPHLIGID DDLLSTGIIL YHLKEGQTYV GREDASTEQD IVLHGLDLES
510 520 530 540 550
EHCVFENAGG TVTLIPLRGS QCSVNGVQIV DATQLNQGAV ILLGRTNMFR
560 570 580 590 600
FNHPKEAAKL REKRKSGLLS SFSLSMTDLS KSCENLSAVM LYNPGLEFER
610 620 630 640 650
QQREELEKLE SKRKLIEEME EKQKSDKAEL ERMQQEVETR RKETEIVQRQ
660 670 680 690 700
IRKQEESLKR RSFHIENKLK DLLAEKERFE EERLREQQGL EQQRRQEEES
710 720 730 740 750
LFRIREELRK LQELNSHEQA EKVQIFQELD RLHQEQNAQS AKLRLEKRRL
760 770 780 790 800
EEEEKEQVQR VAHLEEQLRK RQDTAPLLCP GEAQRAQEEK RELESIREAL
810 820 830 840 850
LQAKEMRAGG DHTCRDELER AQQYFLEFKR RQLVKLASLE KDLVQQKDLL
860 870 880 890 900
SKEVQEEKVA LEHVKCDAGG DPSFLATDDG NILGGPPDLD KIKTAETRLQ
910 920 930 940 950
SREHQLQDLL QNHLPALLEE KQRVLDALDS GVLGLDTTLC QVEKEVGEKE
960 970 980 990 1000
EQIAQYQANA SQLQQLRATF EFTANVARQE EKVRRKEKEI LESQEKQQRE
1010 1020 1030 1040 1050
ALEQAVAKLE QRRSALQRCS TLDLEIQEQR QKLGSLHTSE WSGWQASLET
1060 1070 1080 1090 1100
DGEALEMDPA RLEHEIHQLK QKICEVDGVQ RPHHGILEGQ AVLSSLPPSG
1110 1120 1130 1140 1150
GNSHLAPLMD ARISAYIEEE VQRRLHDLHR AIGDANHTPA DVMKSNEELH
1160 1170 1180 1190 1200
NGTTQRKLKY ERMYSRSLGT NRDDLKDPIK ISIPRYVLCG QGKDEHFEFE
1210 1220 1230 1240 1250
VKISVLDETW TVFRRYSRFR EMHKTLKLKY AELAALEFPP KKLFGNKDER
1260 1270 1280 1290 1300
VVAERRTHLE KYLREFFSVM LQSETSPLHI NKVGLTLSKH TICEFSPFFK
1310
KGVFDYSSHG TG
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7FLY0 | E7FLY0_MOUSE | Kinesin superfamily protein 16B | Kif16b | 1,323 | Annotation score: | ||
A0A1D5RMD4 | A0A1D5RMD4_MOUSE | Kinesin-like protein KIF16B | Kif16b | 1,386 | Annotation score: | ||
A0A1D5RMB3 | A0A1D5RMB3_MOUSE | Kinesin-like protein KIF16B | Kif16b | 719 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL731712 Genomic DNA No translation available. AL731790 Genomic DNA No translation available. AL929136 Genomic DNA No translation available. AB001423 mRNA Translation: BAA22383.1 AK033018 mRNA Translation: BAC28130.2 AK160835 mRNA Translation: BAE36039.1 AK129401 Transcribed RNA Translation: BAC98211.1 Sequence problems. |
CCDSi | CCDS38251.1 |
RefSeqi | NP_001074602.1, NM_001081133.2 |
Genome annotation databases
Ensembli | ENSMUST00000043589; ENSMUSP00000042551; ENSMUSG00000038844 |
GeneIDi | 16558 |
KEGGi | mmu:16558 |
UCSCi | uc008mpz.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL731712 Genomic DNA No translation available. AL731790 Genomic DNA No translation available. AL929136 Genomic DNA No translation available. AB001423 mRNA Translation: BAA22383.1 AK033018 mRNA Translation: BAC28130.2 AK160835 mRNA Translation: BAE36039.1 AK129401 Transcribed RNA Translation: BAC98211.1 Sequence problems. |
CCDSi | CCDS38251.1 |
RefSeqi | NP_001074602.1, NM_001081133.2 |
3D structure databases
SMRi | B1AVY7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200933, 3 interactors |
STRINGi | 10090.ENSMUSP00000042551 |
PTM databases
iPTMneti | B1AVY7 |
PhosphoSitePlusi | B1AVY7 |
Proteomic databases
EPDi | B1AVY7 |
MaxQBi | B1AVY7 |
PaxDbi | B1AVY7 |
PeptideAtlasi | B1AVY7 |
PRIDEi | B1AVY7 |
ProteomicsDBi | 263599 |
Protocols and materials databases
Antibodypediai | 24366, 107 antibodies from 16 providers |
Genome annotation databases
Ensembli | ENSMUST00000043589; ENSMUSP00000042551; ENSMUSG00000038844 |
GeneIDi | 16558 |
KEGGi | mmu:16558 |
UCSCi | uc008mpz.1, mouse |
Organism-specific databases
CTDi | 55614 |
MGIi | MGI:1098240, Kif16b |
VEuPathDBi | HostDB:ENSMUSG00000038844 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG0245, Eukaryota KOG2101, Eukaryota |
GeneTreei | ENSGT00940000162977 |
HOGENOMi | CLU_001485_35_0_1 |
InParanoidi | B1AVY7 |
OMAi | THHEFEV |
OrthoDBi | 76316at2759 |
PhylomeDBi | B1AVY7 |
TreeFami | TF105221 |
Enzyme and pathway databases
Reactomei | R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189, Kinesins |
Miscellaneous databases
BioGRID-ORCSi | 16558, 1 hit in 64 CRISPR screens |
ChiTaRSi | Kif16b, mouse |
PROi | PR:B1AVY7 |
RNActi | B1AVY7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038844, Expressed in submandibular gland and 306 other tissues |
ExpressionAtlasi | B1AVY7, baseline and differential |
Genevisiblei | B1AVY7, MM |
Family and domain databases
Gene3Di | 3.30.1520.10, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase IPR001683, PX_dom IPR036871, PX_dom_sf IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00498, FHA, 1 hit PF00225, Kinesin, 1 hit PF00787, PX, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit SM00312, PX, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF52540, SSF52540, 1 hit SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit PS50195, PX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KI16B_MOUSE | |
Accessioni | B1AVY7Primary (citable) accession number: B1AVY7 Secondary accession number(s): O35056 Q8BZZ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 31, 2011 |
Last sequence update: | April 8, 2008 | |
Last modified: | February 23, 2022 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families