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Protein

Kinesin-like protein KIF16B

Gene

Kif16b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 109ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport
LigandATP-binding, Lipid-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF16B
Gene namesi
Name:Kif16b
Synonyms:Kiaa1590
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1098240 Kif16b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Membrane, Microtubule

Pathology & Biotechi

Disruption phenotypei

Embryonic death. Embryos are arrested at the blastocyst stage: the primitive endoderm and epiblast cannot be distinguished and appear as cell clumps resembling the inner cell mass (ICM) of the blastocyst. Embryos do not develop an epiblast epithelium and the uterine reaction appears to be incomplete. Development of the primitive endoderm and a basement membrane derived from it are severely affected in embryos at 4.5 dpc.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004095001 – 1312Kinesin-like protein KIF16BAdd BLAST1312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei398PhosphoserineBy similarity1
Modified residuei577PhosphothreonineBy similarity1
Modified residuei582PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei1047PhosphoserineBy similarity1
Modified residuei1145PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiB1AVY7
MaxQBiB1AVY7
PaxDbiB1AVY7
PeptideAtlasiB1AVY7
PRIDEiB1AVY7

PTM databases

iPTMnetiB1AVY7
PhosphoSitePlusiB1AVY7

Expressioni

Gene expression databases

BgeeiENSMUSG00000038844 Expressed in 282 organ(s), highest expression level in submandibular gland
ExpressionAtlasiB1AVY7 baseline and differential
GenevisibleiB1AVY7 MM

Interactioni

Subunit structurei

Interacts with PTPN21 (By similarity). Interacts with RAB14.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiB1AVY7, 1 interactor
MINTiB1AVY7
STRINGi10090.ENSMUSP00000042551

Structurei

3D structure databases

ProteinModelPortaliB1AVY7
SMRiB1AVY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 358Kinesin motorPROSITE-ProRule annotationAdd BLAST356
Domaini?480 – ?544FHAAdd BLAST65
Domaini1177 – 1291PXPROSITE-ProRule annotationAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili366 – 425Sequence analysisAdd BLAST60
Coiled coili835 – 913Sequence analysisAdd BLAST79
Coiled coili941 – 1073Sequence analysisAdd BLAST133

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi597 – 798Glu-richAdd BLAST202

Domaini

The PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Does not bind phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (By similarity).By similarity

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
KOG2101 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
HOGENOMiHOG000044239
HOVERGENiHBG099559
InParanoidiB1AVY7
KOiK17916
OMAiLHIDKVG
OrthoDBiEOG091G00V7
PhylomeDBiB1AVY7
TreeFamiTF105221

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR001683 Phox
IPR036871 PX_dom_sf
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00225 Kinesin, 1 hit
PF00787 PX, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS50195 PX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

B1AVY7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVKVAVRV RPMNRREKDL EAKFIIQMEK SKTTITNLKI PEGGTGDSGR
60 70 80 90 100
ERTKTFTYDF SFYSADTKSP DYVSQEMVFK TLGTDVVKSA FEGYNACVFA
110 120 130 140 150
YGQTGSGKSY TMMGNSGDSG LIPRICEALF SRINETTRWD EASFRTEVSY
160 170 180 190 200
LEIYNERVRD LLRRKSSKTF NLRVREHPKE GPYVEDLSKH LVQNYSDVEE
210 220 230 240 250
LMDAGNINRT TAATGMNDVS SRSHAIFTIK FTQAKFDAEM PCETVSKIHL
260 270 280 290 300
VDLAGSERAD ATGATGVRLK EGGNINKSLV TLGNVISALA DLSQDAANPL
310 320 330 340 350
VKKKQVFVPY RDSVLTWLLK DSLGGNSKTI MIATISPADV NYGETLSTLR
360 370 380 390 400
YANRAKNIIN KPTINEDANV KLIRELRAEI ARLKTLLAQG NQIALLDSPT
410 420 430 440 450
ALSMEEKLHQ NEARVQELTK EWTNKWNETQ NILKEQTLAL RKEGIGVVLD
460 470 480 490 500
SELPHLIGID DDLLSTGIIL YHLKEGQTYV GREDASTEQD IVLHGLDLES
510 520 530 540 550
EHCVFENAGG TVTLIPLRGS QCSVNGVQIV DATQLNQGAV ILLGRTNMFR
560 570 580 590 600
FNHPKEAAKL REKRKSGLLS SFSLSMTDLS KSCENLSAVM LYNPGLEFER
610 620 630 640 650
QQREELEKLE SKRKLIEEME EKQKSDKAEL ERMQQEVETR RKETEIVQRQ
660 670 680 690 700
IRKQEESLKR RSFHIENKLK DLLAEKERFE EERLREQQGL EQQRRQEEES
710 720 730 740 750
LFRIREELRK LQELNSHEQA EKVQIFQELD RLHQEQNAQS AKLRLEKRRL
760 770 780 790 800
EEEEKEQVQR VAHLEEQLRK RQDTAPLLCP GEAQRAQEEK RELESIREAL
810 820 830 840 850
LQAKEMRAGG DHTCRDELER AQQYFLEFKR RQLVKLASLE KDLVQQKDLL
860 870 880 890 900
SKEVQEEKVA LEHVKCDAGG DPSFLATDDG NILGGPPDLD KIKTAETRLQ
910 920 930 940 950
SREHQLQDLL QNHLPALLEE KQRVLDALDS GVLGLDTTLC QVEKEVGEKE
960 970 980 990 1000
EQIAQYQANA SQLQQLRATF EFTANVARQE EKVRRKEKEI LESQEKQQRE
1010 1020 1030 1040 1050
ALEQAVAKLE QRRSALQRCS TLDLEIQEQR QKLGSLHTSE WSGWQASLET
1060 1070 1080 1090 1100
DGEALEMDPA RLEHEIHQLK QKICEVDGVQ RPHHGILEGQ AVLSSLPPSG
1110 1120 1130 1140 1150
GNSHLAPLMD ARISAYIEEE VQRRLHDLHR AIGDANHTPA DVMKSNEELH
1160 1170 1180 1190 1200
NGTTQRKLKY ERMYSRSLGT NRDDLKDPIK ISIPRYVLCG QGKDEHFEFE
1210 1220 1230 1240 1250
VKISVLDETW TVFRRYSRFR EMHKTLKLKY AELAALEFPP KKLFGNKDER
1260 1270 1280 1290 1300
VVAERRTHLE KYLREFFSVM LQSETSPLHI NKVGLTLSKH TICEFSPFFK
1310
KGVFDYSSHG TG
Length:1,312
Mass (Da):150,058
Last modified:April 8, 2008 - v1
Checksum:i4397E49FF4E93881
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7FLY0E7FLY0_MOUSE
Kinesin superfamily protein 16B
Kif16b
1,323Annotation score:
A0A1D5RMD4A0A1D5RMD4_MOUSE
Kinesin-like protein KIF16B
Kif16b
1,386Annotation score:
A0A1D5RMB3A0A1D5RMB3_MOUSE
Kinesin-like protein KIF16B
Kif16b
719Annotation score:

Sequence cautioni

The sequence BAC98211 differs from that shown. Partially unspliced pre-RNA.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731712, AL731790, AL929136 Genomic DNA Translation: CAM13299.1
AL731790, AL731712, AL929136 Genomic DNA Translation: CAM13408.1
AL929136, AL731712, AL731790 Genomic DNA Translation: CAM24500.1
AB001423 mRNA Translation: BAA22383.1
AK033018 mRNA Translation: BAC28130.2
AK160835 mRNA Translation: BAE36039.1
AK129401 Transcribed RNA Translation: BAC98211.1 Sequence problems.
CCDSiCCDS38251.1
RefSeqiNP_001074602.1, NM_001081133.2
UniGeneiMm.251934

Genome annotation databases

EnsembliENSMUST00000043589; ENSMUSP00000042551; ENSMUSG00000038844
GeneIDi16558
KEGGimmu:16558
UCSCiuc008mpz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731712, AL731790, AL929136 Genomic DNA Translation: CAM13299.1
AL731790, AL731712, AL929136 Genomic DNA Translation: CAM13408.1
AL929136, AL731712, AL731790 Genomic DNA Translation: CAM24500.1
AB001423 mRNA Translation: BAA22383.1
AK033018 mRNA Translation: BAC28130.2
AK160835 mRNA Translation: BAE36039.1
AK129401 Transcribed RNA Translation: BAC98211.1 Sequence problems.
CCDSiCCDS38251.1
RefSeqiNP_001074602.1, NM_001081133.2
UniGeneiMm.251934

3D structure databases

ProteinModelPortaliB1AVY7
SMRiB1AVY7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB1AVY7, 1 interactor
MINTiB1AVY7
STRINGi10090.ENSMUSP00000042551

PTM databases

iPTMnetiB1AVY7
PhosphoSitePlusiB1AVY7

Proteomic databases

EPDiB1AVY7
MaxQBiB1AVY7
PaxDbiB1AVY7
PeptideAtlasiB1AVY7
PRIDEiB1AVY7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043589; ENSMUSP00000042551; ENSMUSG00000038844
GeneIDi16558
KEGGimmu:16558
UCSCiuc008mpz.1 mouse

Organism-specific databases

CTDi55614
MGIiMGI:1098240 Kif16b
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
KOG2101 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
HOGENOMiHOG000044239
HOVERGENiHBG099559
InParanoidiB1AVY7
KOiK17916
OMAiLHIDKVG
OrthoDBiEOG091G00V7
PhylomeDBiB1AVY7
TreeFamiTF105221

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Miscellaneous databases

PROiPR:B1AVY7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038844 Expressed in 282 organ(s), highest expression level in submandibular gland
ExpressionAtlasiB1AVY7 baseline and differential
GenevisibleiB1AVY7 MM

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR001683 Phox
IPR036871 PX_dom_sf
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00225 Kinesin, 1 hit
PF00787 PX, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SM00312 PX, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS50195 PX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKI16B_MOUSE
AccessioniPrimary (citable) accession number: B1AVY7
Secondary accession number(s): O35056
, Q3TUD2, Q6ZPM0, Q8BZZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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