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Protein
Submitted name:

Collagen, type IV, alpha 6

Gene

Col4a6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central
  • extracellular matrix structural constituent conferring tensile strength Source: BHF-UCL
  • structural molecule activity Source: MGI

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils
R-MMU-3000157 Laminin interactions
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type IV, alpha 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col4a6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2152695 Col4a6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500276194020 – 1691Sequence analysisAdd BLAST1672

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B1AVK5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B1AVK5

PeptideAtlas

More...
PeptideAtlasi
B1AVK5

PRoteomics IDEntifications database

More...
PRIDEi
B1AVK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031273 Expressed in 177 organ(s), highest expression level in prostate gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B1AVK5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2960 Collagen type IV trimer variant 2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000098765

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B1AVK5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B1AVK5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1467 – 1691Collagen IV NC1InterPro annotationAdd BLAST225

Keywords - Domaini

CollagenSAAS annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153991

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000085652

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004933

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B1AVK5

KEGG Orthology (KO)

More...
KOi
K06237

Identification of Orthologs from Complete Genome Data

More...
OMAi
PMMPVGQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0613

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B1AVK5

TreeFam database of animal gene trees

More...
TreeFami
TF344135

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00111 C4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51403 NC1_IV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B1AVK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPGLWLFLV SLCLTKELAE SGQKMSYGKP CGSRDCHGVC TCFPEKGARG
60 70 80 90 100
HPGPIGTQGP AGPEGFTGPT GLSGLKGERG SPGPLGPYGS KGDKGPIGVP
110 120 130 140 150
GFVGISGIPG HPGQPGPRGP PGPDGCNGTQ GAVGFPGPDG YPGILGPPGL
160 170 180 190 200
PGHKGAKGEP VPFQGSITGI RGDPGLPGLD GIPGPSGSSG SPGDAGPIGP
210 220 230 240 250
PGLQGPPGLP GLPGPEGNMG LGFQGEKGVK GDVGLPGPAG PPPSTGELEF
260 270 280 290 300
MGFPKGKKGS KGEPGPPGFP GMSGPPGVPE FGSTGEKGEK GILGLPGPRG
310 320 330 340 350
PMGSEGIQGH PGRQGKKGTS GFPGINGFPG IKGEKGDIGV RGPDSFTDAD
360 370 380 390 400
GAVISGYPGD PGVLGLPGLR GDEGVQGQRG PSGTPGLPSL TGLPGALGPQ
410 420 430 440 450
GFPGLKGDQG NSGRTTFGEA GLPGRVGLPG LPGLPGPSGP PGRTFETGHL
460 470 480 490 500
SNIEPGFPGL QGEQGPKGHQ GLKGVKGDSG FCACEGGAPN IGPHGEPGLP
510 520 530 540 550
GIQGPIGLQG FKGTKGDPGS RGASGPAGTP GLFGPRGQTG LKGKKGEPTV
560 570 580 590 600
SRGSKMSGDK GDPGPQGTPG LAGTPGKDGR PGLPGLPGIQ GDGGSGFPGE
610 620 630 640 650
RGLPGLPGEK GHDGPIGPPG IGLPGPPGPR GLPGDKGVDG LPGQQGLRGA
660 670 680 690 700
QGVTLPCIIP GSYGPSGFPG APGFPGSKGA RGLPGIPGKP GTHGSKGGPG
710 720 730 740 750
SPGLMHLPGL PGFPGVRGEK GLPGFPGLPG KDGYPGKAGS PGLPGFKGAA
760 770 780 790 800
GDIFGAENGA SGEQGLQGLP GDKGFPGDSG LPGPKGLNGK PGMLGPKGER
810 820 830 840 850
GNPGTSGPPG QPGPSGSTDP FGIKGTSGFP GAPGLPGISG HPGKKGQRGD
860 870 880 890 900
IGQPGSTGKR GLPGIKGLPG PQGSPGFLGS PGLSGVTGLP GIEGQKGEKG
910 920 930 940 950
SSGPVGFPGL PGLPGLPGAD GLKGFSGSFG KVGQPGQTGT SGEKGDRGDP
960 970 980 990 1000
GPVGISSPRP PMLNLWFKGE KGSRGSAGSD GFPGPRGDKG EPGIPGLPGP
1010 1020 1030 1040 1050
PGATGQTNTI KGLNGRPGSP GSMGRRGLPG LKGSLGIAGF PGMPGKSGSQ
1060 1070 1080 1090 1100
GLTGTSGLLG ATGIPGLKGD QGQTLGISGS PGPKGQPGEL GFKGVKGKDG
1110 1120 1130 1140 1150
LVGDRGYPGN KGDGGKVGIT GDPGFPGSPG LQGISGMNGD PGLPGSSGHL
1160 1170 1180 1190 1200
GSIGRPGPSG LIGPKGFPGA PGLHGLNGLP GTKGTHGTPG ASITGVPGPA
1210 1220 1230 1240 1250
GLPGPKGERG VPGIVIGDPG KQGSKGQKGD QGSPGLQGPA GTPGAPGISL
1260 1270 1280 1290 1300
PSVIAGQPGD PGRPGLDGER GRPGPPGPPG PPGPSSDQGD PGDSGFPGIP
1310 1320 1330 1340 1350
GLQGFKGNQG LPGFSGLSGE LGLKGMRGEP GLMGTPGKIG QPGDPGFPGM
1360 1370 1380 1390 1400
KGKAGPRGFS GPQGAPGHTP IAEAMQVPPG PLGLPGIDGI PGLIGDPGSQ
1410 1420 1430 1440 1450
GSVGLQGSKG LPGIPGKDGP SGLPGPSGIL GDPGLPGLQG PPGFEGAPGN
1460 1470 1480 1490 1500
QGPIGQPGMP GHGVRVGYTL VKHSQSEQVP LCPTGMSRLW VGYSLLFVEG
1510 1520 1530 1540 1550
QEKAHNQDLG FAGSCLPRFS TMPFIYCNIN EVCHYARRND KSYWLSTTAP
1560 1570 1580 1590 1600
IPMMPVGQTQ IPQYISRCSV CEAPSQAIAV HSQDIIVPQC PLGWHSLWIG
1610 1620 1630 1640 1650
YSFLMHTAAG AEGGGQSLVS PGSCLEDFRA TPFIECSGAR GTCHYFANKY
1660 1670 1680 1690
SFWLTTVEER GQFREEPVSE TLKTGQLHTR VSRCQVCMKT P
Length:1,691
Mass (Da):164,034
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFBC8A730041D37A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL691493 Genomic DNA No translation available.
AL713983 Genomic DNA No translation available.
BX640471 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_444415.2, NM_053185.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.155586

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000101205; ENSMUSP00000098765; ENSMUSG00000031273

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
94216

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:94216

UCSC genome browser

More...
UCSCi
uc012hpp.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691493 Genomic DNA No translation available.
AL713983 Genomic DNA No translation available.
BX640471 Genomic DNA No translation available.
RefSeqiNP_444415.2, NM_053185.2
UniGeneiMm.155586

3D structure databases

ProteinModelPortaliB1AVK5
SMRiB1AVK5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2960 Collagen type IV trimer variant 2
STRINGi10090.ENSMUSP00000098765

Proteomic databases

MaxQBiB1AVK5
PaxDbiB1AVK5
PeptideAtlasiB1AVK5
PRIDEiB1AVK5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101205; ENSMUSP00000098765; ENSMUSG00000031273
GeneIDi94216
KEGGimmu:94216
UCSCiuc012hpp.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1288
MGIiMGI:2152695 Col4a6

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000153991
HOGENOMiHOG000085652
HOVERGENiHBG004933
InParanoidiB1AVK5
KOiK06237
OMAiPMMPVGQ
OrthoDBiEOG091G0613
PhylomeDBiB1AVK5
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils
R-MMU-3000157 Laminin interactions
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031273 Expressed in 177 organ(s), highest expression level in prostate gland
GenevisibleiB1AVK5 MM

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 18 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB1AVK5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1AVK5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: December 5, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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