Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Collagen, type IV, alpha 6

Gene

Col4a6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • extracellular matrix structural constituent Source: GO_Central
  • extracellular matrix structural constituent conferring tensile strength Source: BHF-UCL
  • structural molecule activity Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils
R-MMU-3000157 Laminin interactions
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Submitted name:
Collagen, type IV, alpha 6Imported
Gene namesi
Name:Col4a6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2152695 Col4a6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500276194020 – 1691Sequence analysisAdd BLAST1672

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiB1AVK5
PaxDbiB1AVK5
PeptideAtlasiB1AVK5
PRIDEiB1AVK5

Expressioni

Gene expression databases

BgeeiENSMUSG00000031273 Expressed in 177 organ(s), highest expression level in prostate gland
GenevisibleiB1AVK5 MM

Interactioni

Protein-protein interaction databases

ComplexPortaliCPX-2960 Collagen type IV trimer variant 2
STRINGi10090.ENSMUSP00000098765

Structurei

3D structure databases

ProteinModelPortaliB1AVK5
SMRiB1AVK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1467 – 1691Collagen IV NC1InterPro annotationAdd BLAST225

Keywords - Domaini

CollagenSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140804
HOGENOMiHOG000085652
HOVERGENiHBG004933
InParanoidiB1AVK5
KOiK06237
OMAiPMMPVGQ
OrthoDBiEOG091G0613
PhylomeDBiB1AVK5
TreeFamiTF344135

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 18 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit

Sequencei

Sequence statusi: Complete.

B1AVK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPGLWLFLV SLCLTKELAE SGQKMSYGKP CGSRDCHGVC TCFPEKGARG
60 70 80 90 100
HPGPIGTQGP AGPEGFTGPT GLSGLKGERG SPGPLGPYGS KGDKGPIGVP
110 120 130 140 150
GFVGISGIPG HPGQPGPRGP PGPDGCNGTQ GAVGFPGPDG YPGILGPPGL
160 170 180 190 200
PGHKGAKGEP VPFQGSITGI RGDPGLPGLD GIPGPSGSSG SPGDAGPIGP
210 220 230 240 250
PGLQGPPGLP GLPGPEGNMG LGFQGEKGVK GDVGLPGPAG PPPSTGELEF
260 270 280 290 300
MGFPKGKKGS KGEPGPPGFP GMSGPPGVPE FGSTGEKGEK GILGLPGPRG
310 320 330 340 350
PMGSEGIQGH PGRQGKKGTS GFPGINGFPG IKGEKGDIGV RGPDSFTDAD
360 370 380 390 400
GAVISGYPGD PGVLGLPGLR GDEGVQGQRG PSGTPGLPSL TGLPGALGPQ
410 420 430 440 450
GFPGLKGDQG NSGRTTFGEA GLPGRVGLPG LPGLPGPSGP PGRTFETGHL
460 470 480 490 500
SNIEPGFPGL QGEQGPKGHQ GLKGVKGDSG FCACEGGAPN IGPHGEPGLP
510 520 530 540 550
GIQGPIGLQG FKGTKGDPGS RGASGPAGTP GLFGPRGQTG LKGKKGEPTV
560 570 580 590 600
SRGSKMSGDK GDPGPQGTPG LAGTPGKDGR PGLPGLPGIQ GDGGSGFPGE
610 620 630 640 650
RGLPGLPGEK GHDGPIGPPG IGLPGPPGPR GLPGDKGVDG LPGQQGLRGA
660 670 680 690 700
QGVTLPCIIP GSYGPSGFPG APGFPGSKGA RGLPGIPGKP GTHGSKGGPG
710 720 730 740 750
SPGLMHLPGL PGFPGVRGEK GLPGFPGLPG KDGYPGKAGS PGLPGFKGAA
760 770 780 790 800
GDIFGAENGA SGEQGLQGLP GDKGFPGDSG LPGPKGLNGK PGMLGPKGER
810 820 830 840 850
GNPGTSGPPG QPGPSGSTDP FGIKGTSGFP GAPGLPGISG HPGKKGQRGD
860 870 880 890 900
IGQPGSTGKR GLPGIKGLPG PQGSPGFLGS PGLSGVTGLP GIEGQKGEKG
910 920 930 940 950
SSGPVGFPGL PGLPGLPGAD GLKGFSGSFG KVGQPGQTGT SGEKGDRGDP
960 970 980 990 1000
GPVGISSPRP PMLNLWFKGE KGSRGSAGSD GFPGPRGDKG EPGIPGLPGP
1010 1020 1030 1040 1050
PGATGQTNTI KGLNGRPGSP GSMGRRGLPG LKGSLGIAGF PGMPGKSGSQ
1060 1070 1080 1090 1100
GLTGTSGLLG ATGIPGLKGD QGQTLGISGS PGPKGQPGEL GFKGVKGKDG
1110 1120 1130 1140 1150
LVGDRGYPGN KGDGGKVGIT GDPGFPGSPG LQGISGMNGD PGLPGSSGHL
1160 1170 1180 1190 1200
GSIGRPGPSG LIGPKGFPGA PGLHGLNGLP GTKGTHGTPG ASITGVPGPA
1210 1220 1230 1240 1250
GLPGPKGERG VPGIVIGDPG KQGSKGQKGD QGSPGLQGPA GTPGAPGISL
1260 1270 1280 1290 1300
PSVIAGQPGD PGRPGLDGER GRPGPPGPPG PPGPSSDQGD PGDSGFPGIP
1310 1320 1330 1340 1350
GLQGFKGNQG LPGFSGLSGE LGLKGMRGEP GLMGTPGKIG QPGDPGFPGM
1360 1370 1380 1390 1400
KGKAGPRGFS GPQGAPGHTP IAEAMQVPPG PLGLPGIDGI PGLIGDPGSQ
1410 1420 1430 1440 1450
GSVGLQGSKG LPGIPGKDGP SGLPGPSGIL GDPGLPGLQG PPGFEGAPGN
1460 1470 1480 1490 1500
QGPIGQPGMP GHGVRVGYTL VKHSQSEQVP LCPTGMSRLW VGYSLLFVEG
1510 1520 1530 1540 1550
QEKAHNQDLG FAGSCLPRFS TMPFIYCNIN EVCHYARRND KSYWLSTTAP
1560 1570 1580 1590 1600
IPMMPVGQTQ IPQYISRCSV CEAPSQAIAV HSQDIIVPQC PLGWHSLWIG
1610 1620 1630 1640 1650
YSFLMHTAAG AEGGGQSLVS PGSCLEDFRA TPFIECSGAR GTCHYFANKY
1660 1670 1680 1690
SFWLTTVEER GQFREEPVSE TLKTGQLHTR VSRCQVCMKT P
Length:1,691
Mass (Da):164,034
Last modified:April 8, 2008 - v1
Checksum:iBFBC8A730041D37A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691493 Genomic DNA No translation available.
AL713983 Genomic DNA No translation available.
BX640471 Genomic DNA No translation available.
RefSeqiNP_444415.2, NM_053185.2
UniGeneiMm.155586

Genome annotation databases

EnsembliENSMUST00000101205; ENSMUSP00000098765; ENSMUSG00000031273
GeneIDi94216
KEGGimmu:94216
UCSCiuc012hpp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL691493 Genomic DNA No translation available.
AL713983 Genomic DNA No translation available.
BX640471 Genomic DNA No translation available.
RefSeqiNP_444415.2, NM_053185.2
UniGeneiMm.155586

3D structure databases

ProteinModelPortaliB1AVK5
SMRiB1AVK5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-2960 Collagen type IV trimer variant 2
STRINGi10090.ENSMUSP00000098765

Proteomic databases

MaxQBiB1AVK5
PaxDbiB1AVK5
PeptideAtlasiB1AVK5
PRIDEiB1AVK5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000101205; ENSMUSP00000098765; ENSMUSG00000031273
GeneIDi94216
KEGGimmu:94216
UCSCiuc012hpp.1 mouse

Organism-specific databases

CTDi1288
MGIiMGI:2152695 Col4a6

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140804
HOGENOMiHOG000085652
HOVERGENiHBG004933
InParanoidiB1AVK5
KOiK06237
OMAiPMMPVGQ
OrthoDBiEOG091G0613
PhylomeDBiB1AVK5
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils
R-MMU-3000157 Laminin interactions
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031273 Expressed in 177 organ(s), highest expression level in prostate gland
GenevisibleiB1AVK5 MM

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 18 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1AVK5_MOUSE
AccessioniPrimary (citable) accession number: B1AVK5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again