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Entry version 87 (02 Jun 2021)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Scm polycomb group protein-like 2

Gene

Scml2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Scm polycomb group protein-like 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scml2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1340042, Scml2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B1AVB5

PeptideAtlas

More...
PeptideAtlasi
B1AVB5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
322508

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000000037, Expressed in zygote and 170 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B1AVB5, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B1AVB5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati10 – 108MBTPROSITE-ProRule annotationAdd BLAST99
Repeati116 – 217MBTPROSITE-ProRule annotationAdd BLAST102
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini663 – 707RBRInterPro annotationAdd BLAST45
Domaini737 – 846SLEDInterPro annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni244 – 706DisorderedSequence analysisAdd BLAST463
Regioni852 – 905DisorderedSequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi294 – 328Basic and acidic residuesSequence analysisAdd BLAST35
Compositional biasi335 – 366Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi377 – 394Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi405 – 422Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi436 – 450Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi461 – 478Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi489 – 506Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi520 – 534Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi545 – 562Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi573 – 599Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi610 – 681Polar residuesSequence analysisAdd BLAST72

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159407

Database of Orthologous Groups

More...
OrthoDBi
229086at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1380.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004092, Mbt
IPR033763, SCML2_RBR
IPR021987, SLED
IPR038348, SLED_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02820, MBT, 2 hits
PF17208, RBR, 1 hit
PF12140, SLED, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00561, MBT, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51079, MBT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

B1AVB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQTANEDHF DWDKYLKETG SISAPSEYFR QSKTPPTNEF KIGMKLEARD
60 70 80 90 100
PRNIDSVCVA SVIGITGARL RLRLDGSDNK NDFWRLVDSS DIQPVGTCEQ
110 120 130 140 150
GGDLLQPPLG YTLNTSSWPM FLLRVLTGSE LAPAVFFKEE PPRPLQNNFI
160 170 180 190 200
VGMKIEAVDR KNPFMICPAT IGAVCGDQLH ITFDGWSGAF DYWCDYDSRD
210 220 230 240 250
IFPVGWCRLT GDVLQPPGKI VEKRPRRKRR TRLWRLRTAL LGNEEEAPEA
260 270 280 290 300
AEEPGTSVLT FGDENRTLKD CRGEAAEEPG TSAFTFGDEN RTLKDCQGGW
310 320 330 340 350
KKPKGRGFIK PGKDETRPGK HDQGAPAGKK PRGRGFTQPL EDEARPGRDV
360 370 380 390 400
QVAPAEKKRK GKTVTTPWTE DPRLFADQGD APAEKKRKGK TVTTPWTEDP
410 420 430 440 450
RLFADQGDAP AEKKRKGKTV TTPWTEDPRL FADQGAAPAE KKRKGKTVTT
460 470 480 490 500
PWTEDPRLFA DQGDAPAEKK RKGKTVTTPW TEDPRLFADQ GDAPAEKKRK
510 520 530 540 550
GKTVTTPWTE DPRLFADQGA APAEKKRKGK TVTTPWTEDP RLFADQGDAP
560 570 580 590 600
AEKKRKGKTV TTPWTEDPRL FADQGDAPAE KKPKGKRVTK SRKDQAQFLA
610 620 630 640 650
DEEAMPALFS ALSVSSTERT PPSSSEQPKS STSGKTKSTS RGAQTSRKSP
660 670 680 690 700
RKTSVVQPVP KTSKKAGKSK STGNTSSPKK GITIKIVLPK KKGGKSGKKE
710 720 730 740 750
KSIPVISSTS SASLSTLMKS SSSNKTSAGP SKIVMSTVCV YINKHGDCGP
760 770 780 790 800
FLDPQKVQQL PNHFGPGPVN VILQRTVQAC VNCAFQAKDV FLFLKTDNRG
810 820 830 840 850
GEMITAFFDG KVHTVQLPPV NSASFALRFL ENFCQSLQCD NFLSSQPFRR
860 870 880 890 900
EAQVPTPDTG TDQSKPENGE PKEKRSLKRL SLHPHRSAPV SSKVPRKSGQ

ASKGN
Length:905
Mass (Da):99,529
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FACD38AAE9A8B2C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AVB3B1AVB3_MOUSE
Scm polycomb group protein-like 2
Scml2
969Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AVB4B1AVB4_MOUSE
Scm polycomb group protein-like 2
Scml2
845Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q796E9Q796_MOUSE
Scm polycomb group protein-like 2
Scml2
901Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AVB2B1AVB2_MOUSE
Scm polycomb group protein-like 2
Scml2
827Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BDL9A0A571BDL9_MOUSE
Scm polycomb group protein-like 2
Scml2
367Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AVB1B1AVB1_MOUSE
Scm polycomb group protein-like 2
Scml2
825Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BGE2A0A571BGE2_MOUSE
Scm polycomb group protein-like 2
Scml2
130Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
NP_001277580.1, NM_001290651.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000019101; ENSMUSP00000019101; ENSMUSG00000000037

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
107815

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:107815

UCSC genome browser

More...
UCSCi
uc057atl.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiNP_001277580.1, NM_001290651.1

3D structure databases

SMRiB1AVB5
ModBaseiSearch...

Proteomic databases

MaxQBiB1AVB5
PeptideAtlasiB1AVB5
ProteomicsDBi322508

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
475, 171 antibodies

The DNASU plasmid repository

More...
DNASUi
107815

Genome annotation databases

EnsembliENSMUST00000019101; ENSMUSP00000019101; ENSMUSG00000000037
GeneIDi107815
KEGGimmu:107815
UCSCiuc057atl.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10389
MGIiMGI:1340042, Scml2

Phylogenomic databases

GeneTreeiENSGT00940000159407
OrthoDBi229086at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
107815, 1 hit in 54 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Scml2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000000037, Expressed in zygote and 170 other tissues
ExpressionAtlasiB1AVB5, baseline and differential

Family and domain databases

Gene3Di1.20.1380.20, 1 hit
InterProiView protein in InterPro
IPR004092, Mbt
IPR033763, SCML2_RBR
IPR021987, SLED
IPR038348, SLED_sf
PfamiView protein in Pfam
PF02820, MBT, 2 hits
PF17208, RBR, 1 hit
PF12140, SLED, 1 hit
SMARTiView protein in SMART
SM00561, MBT, 2 hits
PROSITEiView protein in PROSITE
PS51079, MBT, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB1AVB5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1AVB5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 2, 2021
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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