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UniProtKB - B1AVB3 (B1AVB3_MOUSE)

Entry version 94 (10 Feb 2021)
Sequence version 1 (08 Apr 2008)
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Protein
Submitted name:

Scm polycomb group protein-like 2

Gene

Scml2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Scm polycomb group protein-like 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scml2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1340042, Scml2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		B1AVB3

PeptideAtlas

More...PeptideAtlasi		B1AVB3

PRoteomics IDEntifications database

More...PRIDEi		B1AVB3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000000037, Expressed in zygote and 159 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		B1AVB3, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000076593

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		B1AVB3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		B1AVB3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati10 – 108MBTPROSITE-ProRule annotationAdd BLAST99
Repeati116 – 217MBTPROSITE-ProRule annotationAdd BLAST102
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini662 – 706RBRInterPro annotationAdd BLAST45
Domaini736 – 845SLEDInterPro annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni274 – 705DisorderedSequence analysisAdd BLAST432
Regioni851 – 904DisorderedSequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi293 – 327PolyampholyteSequence analysisAdd BLAST35
Compositional biasi334 – 365PolyampholyteSequence analysisAdd BLAST32
Compositional biasi376 – 393PolyampholyteSequence analysisAdd BLAST18
Compositional biasi404 – 421PolyampholyteSequence analysisAdd BLAST18
Compositional biasi435 – 449PolyampholyteSequence analysisAdd BLAST15
Compositional biasi460 – 477PolyampholyteSequence analysisAdd BLAST18
Compositional biasi488 – 505PolyampholyteSequence analysisAdd BLAST18
Compositional biasi519 – 533PolyampholyteSequence analysisAdd BLAST15
Compositional biasi544 – 561PolyampholyteSequence analysisAdd BLAST18
Compositional biasi572 – 598PolyampholyteSequence analysisAdd BLAST27
Compositional biasi609 – 680PolarSequence analysisAdd BLAST72

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota
KOG3766, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159407

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		B1AVB3

TreeFam database of animal gene trees

More...TreeFami		TF106488

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1380.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004092, Mbt
IPR013761, SAM/pointed_sf
IPR033763, SCML2_RBR
IPR021987, SLED
IPR038348, SLED_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02820, MBT, 2 hits
PF17208, RBR, 1 hit
PF12140, SLED, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00561, MBT, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51079, MBT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

B1AVB3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQTANEDHF DWDKYLKETG SISAPSEYFR QSKTPPTNEF KIGMKLEARD 
        60         70         80         90        100
PRNIDSVCVA SVIGITGARL RLRLDGSDNK NDFWRLVDSS DIQPVGTCEQ 
       110        120        130        140        150
GGDLLQPPLG YTLNTSSWPM FLLRVLTGSE LAPAVFFKEE PPRPLQNNFI 
       160        170        180        190        200
VGMKIEAVDR KNPFMICPAT IGAVCGDQLH ITFDGWSGAF DYWCDYDSRD 
       210        220        230        240        250
IFPVGWCRLT GDVLQPPGKI VEKRPRRKRR TRLWRLRTAL LGNEEEAPAA 
       260        270        280        290        300
EEPGTSVLTF GDENRTLKDC RGEAAEEPGT SAFTFGDENR TLKDCQGGWK 
       310        320        330        340        350
KPKGRGFIKP GKDETRPGKH DQGAPAGKKP RGRGFTQPLE DEARPGRDVQ 
       360        370        380        390        400
VAPAEKKRKG KTVTTPWTED PRLFADQGDA PAEKKRKGKT VTTPWTEDPR 
       410        420        430        440        450
LFADQGDAPA EKKRKGKTVT TPWTEDPRLF ADQGAAPAEK KRKGKTVTTP 
       460        470        480        490        500
WTEDPRLFAD QGDAPAEKKR KGKTVTTPWT EDPRLFADQG DAPAEKKRKG 
       510        520        530        540        550
KTVTTPWTED PRLFADQGAA PAEKKRKGKT VTTPWTEDPR LFADQGDAPA 
       560        570        580        590        600
EKKRKGKTVT TPWTEDPRLF ADQGDAPAEK KPKGKRVTKS RKDQAQFLAD 
       610        620        630        640        650
EEAMPALFSA LSVSSTERTP PSSSEQPKSS TSGKTKSTSR GAQTSRKSPR 
       660        670        680        690        700
KTSVVQPVPK TSKKAGKSKS TGNTSSPKKG ITIKIVLPKK KGGKSGKKEK 
       710        720        730        740        750
SIPVISSTSS ASLSTLMKSS SSNKTSAGPS KIVMSTVCVY INKHGDCGPF 
       760        770        780        790        800
LDPQKVQQLP NHFGPGPVNV ILQRTVQACV NCAFQAKDVF LFLKTDNRGG 
       810        820        830        840        850
EMITAFFDGK VHTVQLPPVN SASFALRFLE NFCQSLQCDN FLSSQPFRRE 
       860        870        880        890        900
AQVPTPDTGT DQSKPENGEP KEKRSLKRLS LHPHRSAPVS SKVPRKSGQA 
       910        920        930        940        950
SKASSYITVP DPSVLKQGFC KDPSTWSVDE VIQFMKHTDP QISGPLADLF 
       960 
RQHVTYLLIR FSCCPNASK
Length:969
Mass (Da):106,726
Last modified:April 8, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19A0FCFBA0813208
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AVB5B1AVB5_MOUSE
Scm polycomb group protein-like 2
Scml2
905Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AVB4B1AVB4_MOUSE
Scm polycomb group protein-like 2
Scml2
845Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q796E9Q796_MOUSE
Scm polycomb group protein-like 2
Scml2
901Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AVB2B1AVB2_MOUSE
Scm polycomb group protein-like 2
Scml2
827Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BDL9A0A571BDL9_MOUSE
Scm polycomb group protein-like 2
Scml2
367Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A571BGE2A0A571BGE2_MOUSE
Scm polycomb group protein-like 2
Scml2
130Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AVB1B1AVB1_MOUSE
Scm polycomb group protein-like 2
Scml2
825Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL670462 Genomic DNA No translation available.
AL672233 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000077375; ENSMUSP00000076593; ENSMUSG00000000037

UCSC genome browser

More...UCSCi		uc009utw.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670462 Genomic DNA No translation available.
AL672233 Genomic DNA No translation available.

3D structure databases

SMRiB1AVB3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076593

Proteomic databases

MaxQBiB1AVB3
PeptideAtlasiB1AVB3
PRIDEiB1AVB3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		475, 168 antibodies

Genome annotation databases

EnsembliENSMUST00000077375; ENSMUSP00000076593; ENSMUSG00000000037
UCSCiuc009utw.2, mouse

Organism-specific databases

MGIiMGI:1340042, Scml2

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
KOG3766, Eukaryota
GeneTreeiENSGT00940000159407
InParanoidiB1AVB3
TreeFamiTF106488

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Scml2, mouse
RNActiB1AVB3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000000037, Expressed in zygote and 159 other tissues
ExpressionAtlasiB1AVB3, baseline and differential

Family and domain databases

Gene3Di1.20.1380.20, 1 hit
InterProiView protein in InterPro
IPR004092, Mbt
IPR013761, SAM/pointed_sf
IPR033763, SCML2_RBR
IPR021987, SLED
IPR038348, SLED_sf
PfamiView protein in Pfam
PF02820, MBT, 2 hits
PF17208, RBR, 1 hit
PF12140, SLED, 1 hit
SMARTiView protein in SMART
SM00561, MBT, 2 hits
SUPFAMiSSF47769, SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079, MBT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB1AVB3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B1AVB3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 10, 2021
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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